Comparison of long-term clinical outcomes between revascularization versus medical treatment in patients with silent myocardial ischemia

Ki Hong Choi, Joo Myung Lee, Il Park, Jihoon Kim, Tae Min Rhee, Doyeon Hwang, Jonghanne Park, Taek Kyu Park, Jeong Hoon Yang, Young Bin Song, Joo Yong Hahn, Dong Seop Jeong, Yang Hyun Cho, Wook Sung Kim, Kiick Sung, Mi Ja Jang, Ji Dong Sung, Jin Ho Choi, Seung Hyuk Choi, Bon Kwon KooYoung Tak Lee, Eun Kyoung Kim, Sung A. Chang, Sung Ji Park, Jin Oh Choi, Sang Chol Lee, Seung Woo Park, Young Seok Cho, Joon Young Choi, Hyeon Cheol Gwon, Jae K. Oh

Research output: Contribution to journalArticle

4 Scopus citations

Abstract

Background: There have been limited and conflicting results regarding the prognostic impact of revascularization treatment on the long-term clinical outcomes of silent ischemia. The current study aimed to determine whether revascularization treatment compared with medical treatment (MT) alone reduces long-term risk of cardiac death of asymptomatic patients with objective evidence of inducible myocardial ischemia. Methods: A total of 1473 consecutive asymptomatic patients with evidence of inducible myocardial ischemia were selected from a prospective institutional registry. All patients showed at least 1 epicardial coronary stenosis with ≥50% diameter stenosis in coronary angiography. Patients were classified according to their treatment strategies. The primary outcome was cardiac death up to 10 years. Results: Among the total population, 709 patients (48.1%) received revascularization treatment including percutaneous coronary intervention (PCI, n = 558) or coronary artery bypass graft surgery (CABG, n = 151), with the remaining patients (764 patients, 51.9%) receiving MT alone. During the follow-up period, the revascularization treatment group showed a significantly lower risk of cardiac death compared with the MT alone group (25.4% vs. 33.7%, HR 0.624, 95%CI 0.498–0.781, p < 0.001). Among revascularized patients, patients with negative non-invasive stress test results after revascularization showed significantly lower risk of cardiac death compared to those with residual myocardial ischemia (8.9% vs. 18.7%, HR 0.406, 95% CI 0.175–0.942, p = 0.036). Conclusions: In patients with silent myocardial ischemia, revascularization treatment was associated with significantly lower long-term risk of cardiac death compared with the MT alone group. The current results support contemporary practice of ischemia-directed revascularization, even in patients with silent myocardial ischemia.

Original languageEnglish (US)
Pages (from-to)47-53
Number of pages7
JournalInternational Journal of Cardiology
Volume277
DOIs
StatePublished - Feb 15 2019

Keywords

  • Coronary artery bypass graft surgery
  • Coronary artery disease
  • Outcomes
  • Percutaneous coronary intervention
  • Silent myocardial ischemia

ASJC Scopus subject areas

  • Cardiology and Cardiovascular Medicine

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    Choi, K. H., Lee, J. M., Park, I., Kim, J., Rhee, T. M., Hwang, D., Park, J., Park, T. K., Yang, J. H., Song, Y. B., Hahn, J. Y., Jeong, D. S., Cho, Y. H., Kim, W. S., Sung, K., Jang, M. J., Sung, J. D., Choi, J. H., Choi, S. H., ... Oh, J. K. (2019). Comparison of long-term clinical outcomes between revascularization versus medical treatment in patients with silent myocardial ischemia. International Journal of Cardiology, 277, 47-53. https://doi.org/10.1016/j.ijcard.2018.08.006