Comparison of in-hospital and one-year outcomes in patients with and without diabetes mellitus undergoing percutaneous catheter intervention (from the National Heart, Lung, and Blood Institute Dynamic Registry)

Warren K. Laskey, Faith Selzer, Helen A. Vlachos, Janet Johnston, Alice Jacobs, Spencer B. King, David Holmes, John Douglas, Peter Block, Robert Wilensky, David O. Williams, Katherine Detre

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Abstract

Extrapolation of improvements in percutaneous coronary intervention (PCI) and outcomes to patients with diabetes has not been systematically examined in clinical practice. Two waves of consecutive patients (n = 4,629) who underwent PCI from July 1997 to June 1999 enrolled in the National Heart, Lung, and Blood Institute Dynamic Registry comprise the study population. There were 1,058 patients with treated diabetes and 3,571 patients without clinically evident diabetes. As a group, patients with diabetes tended to have more clinical, angiographic, and procedural risk factors. Although crude in-hospital mortality rates were higher in patients with diabetes (diabetics 2.3%, nondiabetics 1.3%; p = 0.02), the adjusted risk of in-hospital death (odds ratio 1.46, 95% confidence interval [CI] 0.80 to 2.66) was not significantly different. At 1 year, patients with diabetes had a significantly higher adjusted risk of mortality (risk ratio [RR] 1.80, 95% CI 1.35 to 2.41) and need for repeat revascularization (RR 1.40, 95% CI 1.13 to 1.74). There was a significant interaction between stent use and diabetic status with the need for repeat revascularization (adjusted RR in nondiabetics 0.73, 95% CI 0.61 to 0.88; adjusted RR in patients with diabetes 1.20, 95% CI 0.88 to 1.65). Beta blockers at the time of hospital discharge were significantly associated with reduced mortality rates at 1 year in both groups.

Original languageEnglish (US)
Pages (from-to)1062-1067
Number of pages6
JournalAmerican Journal of Cardiology
Volume90
Issue number10
DOIs
StatePublished - Nov 15 2002

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National Heart, Lung, and Blood Institute (U.S.)
Registries
Diabetes Mellitus
Catheters
Odds Ratio
Confidence Intervals
Percutaneous Coronary Intervention
Mortality
Hospital Mortality
Stents

ASJC Scopus subject areas

  • Cardiology and Cardiovascular Medicine

Cite this

Comparison of in-hospital and one-year outcomes in patients with and without diabetes mellitus undergoing percutaneous catheter intervention (from the National Heart, Lung, and Blood Institute Dynamic Registry). / Laskey, Warren K.; Selzer, Faith; Vlachos, Helen A.; Johnston, Janet; Jacobs, Alice; King, Spencer B.; Holmes, David; Douglas, John; Block, Peter; Wilensky, Robert; Williams, David O.; Detre, Katherine.

In: American Journal of Cardiology, Vol. 90, No. 10, 15.11.2002, p. 1062-1067.

Research output: Contribution to journalArticle

Laskey, Warren K. ; Selzer, Faith ; Vlachos, Helen A. ; Johnston, Janet ; Jacobs, Alice ; King, Spencer B. ; Holmes, David ; Douglas, John ; Block, Peter ; Wilensky, Robert ; Williams, David O. ; Detre, Katherine. / Comparison of in-hospital and one-year outcomes in patients with and without diabetes mellitus undergoing percutaneous catheter intervention (from the National Heart, Lung, and Blood Institute Dynamic Registry). In: American Journal of Cardiology. 2002 ; Vol. 90, No. 10. pp. 1062-1067.
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