Abstract
Carcinoid tumors and pancreatic endocrine tumors are uncommon neuroendocrine neoplasms, and their genetic alterations are not well characterized. These tumors have site-specific differences in neuroendocrine characteristics, clinical course and genetic alterations. We compared clinicopathological features and loss of heterozygosity of chromosomes 11q, 16q and 18, and BRAF gene mutations in 47 patients with neuroendocrine tumors including 16 with pancreatic endocrine tumors, 15 with nonileal carcinoid tumors and 16 with ileal carcinoid tumors. Patients with carcinoid tumors had more frequent history of alcohol consumption compared to patients with pancreatic endocrine tumors (P = 0.02), and patients with ileal carcinoid tumors more frequently had liver metastasis compared to patients with nonileal carcinoid tumors and pancreatic endocrine tumors (P = 0.02). Allelic loss of chromosome 11q was present in 21% of tumors, chromosome 16q in 13%, and chromosome 18 in 30%. These alterations differed with the anatomical subsite of tumor: allelic loss of chromosome 18 was present in 69% of ileal carcinoid tumors, 13% of nonileal carcinoid tumors and 6% of pancreatic endocrine tumors (P = 0.001). In contrast to pancreatic endocrine tumors and nonileal carcinoid tumors, all 11 ileal tumors with loss of chromosome 18 had complete loss of both chromosomal arms. No BRAF mutations were identified. Complete allelic loss of chromosome 18 was associated with smaller tumor size (P = 0.02). Our study indicates that genetic alterations vary by tumor subsite and clinicopathologic features, and ileal carcinoid tumors have distinctive clinicopathologic and genetic profiles.
| Original language | English (US) |
|---|---|
| Pages (from-to) | 1079-1087 |
| Number of pages | 9 |
| Journal | Modern Pathology |
| Volume | 18 |
| Issue number | 8 |
| DOIs | |
| State | Published - Aug 2005 |
| Externally published | Yes |
Fingerprint
Keywords
- Allelic loss
- BRAF mutations
- Carcinoid tumor
- Pancreatic endocrine tumor
ASJC Scopus subject areas
- Pathology and Forensic Medicine
Cite this
Comparison of genetic alterations in neuroendocrine tumors : Frequent loss of chromosome 18 in ileal carcinoid tumors. / Wang, Gordon G.; Yao, James C.; Worah, Samidha; White, Jill A.; Luna, Rene; Wu, Tsung Teh; Hamilton, Stanley R.; Rashid, Asif.
In: Modern Pathology, Vol. 18, No. 8, 08.2005, p. 1079-1087.Research output: Contribution to journal › Article
}
TY - JOUR
T1 - Comparison of genetic alterations in neuroendocrine tumors
T2 - Frequent loss of chromosome 18 in ileal carcinoid tumors
AU - Wang, Gordon G.
AU - Yao, James C.
AU - Worah, Samidha
AU - White, Jill A.
AU - Luna, Rene
AU - Wu, Tsung Teh
AU - Hamilton, Stanley R.
AU - Rashid, Asif
PY - 2005/8
Y1 - 2005/8
N2 - Carcinoid tumors and pancreatic endocrine tumors are uncommon neuroendocrine neoplasms, and their genetic alterations are not well characterized. These tumors have site-specific differences in neuroendocrine characteristics, clinical course and genetic alterations. We compared clinicopathological features and loss of heterozygosity of chromosomes 11q, 16q and 18, and BRAF gene mutations in 47 patients with neuroendocrine tumors including 16 with pancreatic endocrine tumors, 15 with nonileal carcinoid tumors and 16 with ileal carcinoid tumors. Patients with carcinoid tumors had more frequent history of alcohol consumption compared to patients with pancreatic endocrine tumors (P = 0.02), and patients with ileal carcinoid tumors more frequently had liver metastasis compared to patients with nonileal carcinoid tumors and pancreatic endocrine tumors (P = 0.02). Allelic loss of chromosome 11q was present in 21% of tumors, chromosome 16q in 13%, and chromosome 18 in 30%. These alterations differed with the anatomical subsite of tumor: allelic loss of chromosome 18 was present in 69% of ileal carcinoid tumors, 13% of nonileal carcinoid tumors and 6% of pancreatic endocrine tumors (P = 0.001). In contrast to pancreatic endocrine tumors and nonileal carcinoid tumors, all 11 ileal tumors with loss of chromosome 18 had complete loss of both chromosomal arms. No BRAF mutations were identified. Complete allelic loss of chromosome 18 was associated with smaller tumor size (P = 0.02). Our study indicates that genetic alterations vary by tumor subsite and clinicopathologic features, and ileal carcinoid tumors have distinctive clinicopathologic and genetic profiles.
AB - Carcinoid tumors and pancreatic endocrine tumors are uncommon neuroendocrine neoplasms, and their genetic alterations are not well characterized. These tumors have site-specific differences in neuroendocrine characteristics, clinical course and genetic alterations. We compared clinicopathological features and loss of heterozygosity of chromosomes 11q, 16q and 18, and BRAF gene mutations in 47 patients with neuroendocrine tumors including 16 with pancreatic endocrine tumors, 15 with nonileal carcinoid tumors and 16 with ileal carcinoid tumors. Patients with carcinoid tumors had more frequent history of alcohol consumption compared to patients with pancreatic endocrine tumors (P = 0.02), and patients with ileal carcinoid tumors more frequently had liver metastasis compared to patients with nonileal carcinoid tumors and pancreatic endocrine tumors (P = 0.02). Allelic loss of chromosome 11q was present in 21% of tumors, chromosome 16q in 13%, and chromosome 18 in 30%. These alterations differed with the anatomical subsite of tumor: allelic loss of chromosome 18 was present in 69% of ileal carcinoid tumors, 13% of nonileal carcinoid tumors and 6% of pancreatic endocrine tumors (P = 0.001). In contrast to pancreatic endocrine tumors and nonileal carcinoid tumors, all 11 ileal tumors with loss of chromosome 18 had complete loss of both chromosomal arms. No BRAF mutations were identified. Complete allelic loss of chromosome 18 was associated with smaller tumor size (P = 0.02). Our study indicates that genetic alterations vary by tumor subsite and clinicopathologic features, and ileal carcinoid tumors have distinctive clinicopathologic and genetic profiles.
KW - Allelic loss
KW - BRAF mutations
KW - Carcinoid tumor
KW - Pancreatic endocrine tumor
UR - http://www.scopus.com/inward/record.url?scp=24044507296&partnerID=8YFLogxK
UR - http://www.scopus.com/inward/citedby.url?scp=24044507296&partnerID=8YFLogxK
U2 - 10.1038/modpathol.3800389
DO - 10.1038/modpathol.3800389
M3 - Article
C2 - 15920555
AN - SCOPUS:24044507296
VL - 18
SP - 1079
EP - 1087
JO - Modern Pathology
JF - Modern Pathology
SN - 0893-3952
IS - 8
ER -