Comparison of fetal lung area to head circumference ratio with lung volume in the prediction of postnatal outcome in diaphragmatic hernia

J. C. Jani, C. F A Peralta, Rodrigo Ruano, A. Benachi, E. Done, K. H. Nicolaides, J. A. Deprest

Research output: Contribution to journalArticle

49 Citations (Scopus)

Abstract

Objectives: To compare prediction of postnatal survival in isolated diaphragmatic hernia by prenatal two-dimensional (2D) versus three-dimensional (3D) sonographic assessment of the contralateral lung. Methods: The lung area to head circumference ratio (LHR) of the contralateral lung was measured and expressed as a percentage of the normal mean for gestation (O/E) in 47 fetuses with isolated diaphragmatic hernia at 26 (range, 21-36) weeks of gestation. The lung area was measured by tracing the limits of the lungs (LHR trace) and by multiplying the longest diameter by its perpendicular (LHR diameters). The contralateral lung volume was measured by the Virtual Organ Computer-Aided anaLysis method and the O/E was calculated. Regression analysis was used to determine the significance of the LHRs and volume in the prediction of postnatal survival. Results: The survival rate was 59.6% (28 of 47). There were significant associations between O/E LHR trace and O/E LHR diameters, and between each O/E LHR and O/E volume, but multiple regression analysis demonstrated that significant prediction of survival was provided only by O/E LHR trace and intrathoracic herniation of the liver. Conclusions: In diaphragmatic hernia prenatal prediction of postnatal outcome is better by 2D measurement of LHR trace than it is by 3D measurement of lung volume.

Original languageEnglish (US)
Pages (from-to)850-854
Number of pages5
JournalUltrasound in Obstetrics and Gynecology
Volume30
Issue number6
DOIs
StatePublished - Nov 1 2007
Externally publishedYes

Fingerprint

Diaphragmatic Hernia
circumferences
lungs
Head
Lung
predictions
Regression Analysis
regression analysis
Lung Volume Measurements
Pregnancy
fetuses
tracing
liver
organs
Fetus
Liver

Keywords

  • Congenital diaphragmatic hernia
  • Lung area to head circumference ratio
  • Lung volume
  • Pulmonary hypoplasia
  • Three-dimensional ultrasound

ASJC Scopus subject areas

  • Obstetrics and Gynecology
  • Radiology Nuclear Medicine and imaging
  • Radiological and Ultrasound Technology
  • Reproductive Medicine
  • Acoustics and Ultrasonics

Cite this

Comparison of fetal lung area to head circumference ratio with lung volume in the prediction of postnatal outcome in diaphragmatic hernia. / Jani, J. C.; Peralta, C. F A; Ruano, Rodrigo; Benachi, A.; Done, E.; Nicolaides, K. H.; Deprest, J. A.

In: Ultrasound in Obstetrics and Gynecology, Vol. 30, No. 6, 01.11.2007, p. 850-854.

Research output: Contribution to journalArticle

Jani, J. C. ; Peralta, C. F A ; Ruano, Rodrigo ; Benachi, A. ; Done, E. ; Nicolaides, K. H. ; Deprest, J. A. / Comparison of fetal lung area to head circumference ratio with lung volume in the prediction of postnatal outcome in diaphragmatic hernia. In: Ultrasound in Obstetrics and Gynecology. 2007 ; Vol. 30, No. 6. pp. 850-854.
@article{d05b3eddd16a44ac955107571434e2e1,
title = "Comparison of fetal lung area to head circumference ratio with lung volume in the prediction of postnatal outcome in diaphragmatic hernia",
abstract = "Objectives: To compare prediction of postnatal survival in isolated diaphragmatic hernia by prenatal two-dimensional (2D) versus three-dimensional (3D) sonographic assessment of the contralateral lung. Methods: The lung area to head circumference ratio (LHR) of the contralateral lung was measured and expressed as a percentage of the normal mean for gestation (O/E) in 47 fetuses with isolated diaphragmatic hernia at 26 (range, 21-36) weeks of gestation. The lung area was measured by tracing the limits of the lungs (LHR trace) and by multiplying the longest diameter by its perpendicular (LHR diameters). The contralateral lung volume was measured by the Virtual Organ Computer-Aided anaLysis method and the O/E was calculated. Regression analysis was used to determine the significance of the LHRs and volume in the prediction of postnatal survival. Results: The survival rate was 59.6{\%} (28 of 47). There were significant associations between O/E LHR trace and O/E LHR diameters, and between each O/E LHR and O/E volume, but multiple regression analysis demonstrated that significant prediction of survival was provided only by O/E LHR trace and intrathoracic herniation of the liver. Conclusions: In diaphragmatic hernia prenatal prediction of postnatal outcome is better by 2D measurement of LHR trace than it is by 3D measurement of lung volume.",
keywords = "Congenital diaphragmatic hernia, Lung area to head circumference ratio, Lung volume, Pulmonary hypoplasia, Three-dimensional ultrasound",
author = "Jani, {J. C.} and Peralta, {C. F A} and Rodrigo Ruano and A. Benachi and E. Done and Nicolaides, {K. H.} and Deprest, {J. A.}",
year = "2007",
month = "11",
day = "1",
doi = "10.1002/uog.5167",
language = "English (US)",
volume = "30",
pages = "850--854",
journal = "Ultrasound in Obstetrics and Gynecology",
issn = "0960-7692",
publisher = "John Wiley and Sons Ltd",
number = "6",

}

TY - JOUR

T1 - Comparison of fetal lung area to head circumference ratio with lung volume in the prediction of postnatal outcome in diaphragmatic hernia

AU - Jani, J. C.

AU - Peralta, C. F A

AU - Ruano, Rodrigo

AU - Benachi, A.

AU - Done, E.

AU - Nicolaides, K. H.

AU - Deprest, J. A.

PY - 2007/11/1

Y1 - 2007/11/1

N2 - Objectives: To compare prediction of postnatal survival in isolated diaphragmatic hernia by prenatal two-dimensional (2D) versus three-dimensional (3D) sonographic assessment of the contralateral lung. Methods: The lung area to head circumference ratio (LHR) of the contralateral lung was measured and expressed as a percentage of the normal mean for gestation (O/E) in 47 fetuses with isolated diaphragmatic hernia at 26 (range, 21-36) weeks of gestation. The lung area was measured by tracing the limits of the lungs (LHR trace) and by multiplying the longest diameter by its perpendicular (LHR diameters). The contralateral lung volume was measured by the Virtual Organ Computer-Aided anaLysis method and the O/E was calculated. Regression analysis was used to determine the significance of the LHRs and volume in the prediction of postnatal survival. Results: The survival rate was 59.6% (28 of 47). There were significant associations between O/E LHR trace and O/E LHR diameters, and between each O/E LHR and O/E volume, but multiple regression analysis demonstrated that significant prediction of survival was provided only by O/E LHR trace and intrathoracic herniation of the liver. Conclusions: In diaphragmatic hernia prenatal prediction of postnatal outcome is better by 2D measurement of LHR trace than it is by 3D measurement of lung volume.

AB - Objectives: To compare prediction of postnatal survival in isolated diaphragmatic hernia by prenatal two-dimensional (2D) versus three-dimensional (3D) sonographic assessment of the contralateral lung. Methods: The lung area to head circumference ratio (LHR) of the contralateral lung was measured and expressed as a percentage of the normal mean for gestation (O/E) in 47 fetuses with isolated diaphragmatic hernia at 26 (range, 21-36) weeks of gestation. The lung area was measured by tracing the limits of the lungs (LHR trace) and by multiplying the longest diameter by its perpendicular (LHR diameters). The contralateral lung volume was measured by the Virtual Organ Computer-Aided anaLysis method and the O/E was calculated. Regression analysis was used to determine the significance of the LHRs and volume in the prediction of postnatal survival. Results: The survival rate was 59.6% (28 of 47). There were significant associations between O/E LHR trace and O/E LHR diameters, and between each O/E LHR and O/E volume, but multiple regression analysis demonstrated that significant prediction of survival was provided only by O/E LHR trace and intrathoracic herniation of the liver. Conclusions: In diaphragmatic hernia prenatal prediction of postnatal outcome is better by 2D measurement of LHR trace than it is by 3D measurement of lung volume.

KW - Congenital diaphragmatic hernia

KW - Lung area to head circumference ratio

KW - Lung volume

KW - Pulmonary hypoplasia

KW - Three-dimensional ultrasound

UR - http://www.scopus.com/inward/record.url?scp=36749090678&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=36749090678&partnerID=8YFLogxK

U2 - 10.1002/uog.5167

DO - 10.1002/uog.5167

M3 - Article

C2 - 17937452

AN - SCOPUS:36749090678

VL - 30

SP - 850

EP - 854

JO - Ultrasound in Obstetrics and Gynecology

JF - Ultrasound in Obstetrics and Gynecology

SN - 0960-7692

IS - 6

ER -