Comparison of effects of medical and surgical therapy on survival in severe angina pectoris and two-vessel coronary artery disease with and without left ventricular dysfunction: A coronary artery surgery study registry study

Michael B. Mock, Lloyd D. Fisher, David Holmes, Bernard J. Gersh, Hartzell V Schaff, Mary McConney, William J. Rogers, George C. Kaiser, Thomas J. Ryan, William O. Myers, Thomas Killip, in the Coronary Artery Surgery Study Participants in the Coronary Artery Surgery Study

Research output: Contribution to journalArticle

43 Citations (Scopus)

Abstract

This nonrandomized study compared the results of early coronary artery bypass grafting to those of initial medical therapy in a group of 2,023 patients with severe angina pectoris and 2 major epicardial coronary arteries having ≥70% diameter luminal narrowing. Medical therapy was selected for 706 patients, and 1,317 patients were treated by coronary artery bypass grafting. The 6-year survival rate was 76% for patiente treated medically and 89% for patients treated surgically (p < 0.0001). Cox multivariate analysis showed that surgical treatment was a beneficial independent predictor of survival (p < 0.001). For patients with 2-vessel coronary artery disease who had Canadian Heart Association class III and IV angina at presentation, surgical therapy provided a survival advantage for patients with impaired left ventricular function and proximal narrowing of 1 or more coronary arteries.

Original languageEnglish (US)
Pages (from-to)1198-1203
Number of pages6
JournalThe American Journal of Cardiology
Volume61
Issue number15
DOIs
StatePublished - Jun 1 1988

Fingerprint

Angina Pectoris
Left Ventricular Dysfunction
Registries
Coronary Artery Disease
Coronary Vessels
Survival
Coronary Artery Bypass
Therapeutics
Left Ventricular Function
Multivariate Analysis
Survival Rate

ASJC Scopus subject areas

  • Cardiology and Cardiovascular Medicine

Cite this

Comparison of effects of medical and surgical therapy on survival in severe angina pectoris and two-vessel coronary artery disease with and without left ventricular dysfunction : A coronary artery surgery study registry study. / Mock, Michael B.; Fisher, Lloyd D.; Holmes, David; Gersh, Bernard J.; Schaff, Hartzell V; McConney, Mary; Rogers, William J.; Kaiser, George C.; Ryan, Thomas J.; Myers, William O.; Killip, Thomas; Participants in the Coronary Artery Surgery Study, in the Coronary Artery Surgery Study.

In: The American Journal of Cardiology, Vol. 61, No. 15, 01.06.1988, p. 1198-1203.

Research output: Contribution to journalArticle

Mock, Michael B. ; Fisher, Lloyd D. ; Holmes, David ; Gersh, Bernard J. ; Schaff, Hartzell V ; McConney, Mary ; Rogers, William J. ; Kaiser, George C. ; Ryan, Thomas J. ; Myers, William O. ; Killip, Thomas ; Participants in the Coronary Artery Surgery Study, in the Coronary Artery Surgery Study. / Comparison of effects of medical and surgical therapy on survival in severe angina pectoris and two-vessel coronary artery disease with and without left ventricular dysfunction : A coronary artery surgery study registry study. In: The American Journal of Cardiology. 1988 ; Vol. 61, No. 15. pp. 1198-1203.
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abstract = "This nonrandomized study compared the results of early coronary artery bypass grafting to those of initial medical therapy in a group of 2,023 patients with severe angina pectoris and 2 major epicardial coronary arteries having ≥70{\%} diameter luminal narrowing. Medical therapy was selected for 706 patients, and 1,317 patients were treated by coronary artery bypass grafting. The 6-year survival rate was 76{\%} for patiente treated medically and 89{\%} for patients treated surgically (p < 0.0001). Cox multivariate analysis showed that surgical treatment was a beneficial independent predictor of survival (p < 0.001). For patients with 2-vessel coronary artery disease who had Canadian Heart Association class III and IV angina at presentation, surgical therapy provided a survival advantage for patients with impaired left ventricular function and proximal narrowing of 1 or more coronary arteries.",
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