Comparison of diagnostic accuracies of two- and three-dimensional MR elastography of the liver

Hiroyuki Morisaka, Utaroh Motosugi, Kevin J. Glaser, Shintaro Ichikawa, Richard Lorne Ehman, Katsuhiro Sano, Tomoaki Ichikawa, Hiroshi Onishi

Research output: Contribution to journalArticle

13 Citations (Scopus)

Abstract

Purpose: To evaluate the effect of imaging sequence (spin-echo echo-planar imaging [EPI] and gradient-echo [GRE]) and postprocessing method (two-dimensional [2D] and 3D inversion algorithms) on liver MR elastography (MRE) and to validate the diagnostic performance of EPI-MRE3D versus conventional GRE-MRE2D for liver fibrosis staging. Materials and Methods: Three MRE methods (EPI-MRE3D, EPI-MRE2D, and GRE-MRE2D) were performed on soft and mildly stiff phantoms and 58 patients with chronic liver disease using a 3 Tesla clinical MRI scanner, and stiffness values were compared among the three methods. A validation study comprised 73 patients with histological liver fibrosis (F0-4, METAVIR system). Areas under the receiver operating characteristic curves (AUCs) and accuracies for diagnosing significant fibrosis (F3-4) and cirrhosis (F4) were compared between EPI-MRE3D and GRE-MRE2D. Results: Stiffness values of the soft and mildly stiff phantoms were 2.4 kPa and 4.0 kPa by EPI-MRE3D; 2.6 kPa and 4.2 kPa by EPI-MRE2D; and 2.7 kPa and 4.2 kPa by GRE-MRE2D. In patients, EPI-MRE3D provided significantly lower stiffness values than other methods (P<0.001). However, there was no significant difference between GRE-MRE2D and EPI-MRE2D (P=0.12). The AUCs and accuracies of EPI-MRE3D and GRE-MRE2D were statistically equivalent in the diagnoses of significant fibrosis (F3-4) and cirrhosis (F4) (all P<0.005). Conclusion: EPI-MRE3D showed modestly lower liver stiffness values than conventional GRE-MRE2D. The diagnostic performances of EPI-MRE3D and GRE-MRE2D were equivalent for liver fibrosis staging.

Original languageEnglish (US)
JournalJournal of Magnetic Resonance Imaging
DOIs
StateAccepted/In press - 2016

Fingerprint

Echo-Planar Imaging
Elasticity Imaging Techniques
Liver
Fibrosis
Liver Cirrhosis
Area Under Curve
Validation Studies
ROC Curve
Liver Diseases

Keywords

  • Echo planar imaging (EPI)
  • Gradient-echo imaging (GRE)
  • Liver fibrosis staging
  • Magnetic resonance elastography (MRE)
  • Three-dimensional postprocessing

ASJC Scopus subject areas

  • Radiology Nuclear Medicine and imaging

Cite this

Comparison of diagnostic accuracies of two- and three-dimensional MR elastography of the liver. / Morisaka, Hiroyuki; Motosugi, Utaroh; Glaser, Kevin J.; Ichikawa, Shintaro; Ehman, Richard Lorne; Sano, Katsuhiro; Ichikawa, Tomoaki; Onishi, Hiroshi.

In: Journal of Magnetic Resonance Imaging, 2016.

Research output: Contribution to journalArticle

Morisaka, Hiroyuki ; Motosugi, Utaroh ; Glaser, Kevin J. ; Ichikawa, Shintaro ; Ehman, Richard Lorne ; Sano, Katsuhiro ; Ichikawa, Tomoaki ; Onishi, Hiroshi. / Comparison of diagnostic accuracies of two- and three-dimensional MR elastography of the liver. In: Journal of Magnetic Resonance Imaging. 2016.
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abstract = "Purpose: To evaluate the effect of imaging sequence (spin-echo echo-planar imaging [EPI] and gradient-echo [GRE]) and postprocessing method (two-dimensional [2D] and 3D inversion algorithms) on liver MR elastography (MRE) and to validate the diagnostic performance of EPI-MRE3D versus conventional GRE-MRE2D for liver fibrosis staging. Materials and Methods: Three MRE methods (EPI-MRE3D, EPI-MRE2D, and GRE-MRE2D) were performed on soft and mildly stiff phantoms and 58 patients with chronic liver disease using a 3 Tesla clinical MRI scanner, and stiffness values were compared among the three methods. A validation study comprised 73 patients with histological liver fibrosis (F0-4, METAVIR system). Areas under the receiver operating characteristic curves (AUCs) and accuracies for diagnosing significant fibrosis (F3-4) and cirrhosis (F4) were compared between EPI-MRE3D and GRE-MRE2D. Results: Stiffness values of the soft and mildly stiff phantoms were 2.4 kPa and 4.0 kPa by EPI-MRE3D; 2.6 kPa and 4.2 kPa by EPI-MRE2D; and 2.7 kPa and 4.2 kPa by GRE-MRE2D. In patients, EPI-MRE3D provided significantly lower stiffness values than other methods (P<0.001). However, there was no significant difference between GRE-MRE2D and EPI-MRE2D (P=0.12). The AUCs and accuracies of EPI-MRE3D and GRE-MRE2D were statistically equivalent in the diagnoses of significant fibrosis (F3-4) and cirrhosis (F4) (all P<0.005). Conclusion: EPI-MRE3D showed modestly lower liver stiffness values than conventional GRE-MRE2D. The diagnostic performances of EPI-MRE3D and GRE-MRE2D were equivalent for liver fibrosis staging.",
keywords = "Echo planar imaging (EPI), Gradient-echo imaging (GRE), Liver fibrosis staging, Magnetic resonance elastography (MRE), Three-dimensional postprocessing",
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AU - Morisaka, Hiroyuki

AU - Motosugi, Utaroh

AU - Glaser, Kevin J.

AU - Ichikawa, Shintaro

AU - Ehman, Richard Lorne

AU - Sano, Katsuhiro

AU - Ichikawa, Tomoaki

AU - Onishi, Hiroshi

PY - 2016

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N2 - Purpose: To evaluate the effect of imaging sequence (spin-echo echo-planar imaging [EPI] and gradient-echo [GRE]) and postprocessing method (two-dimensional [2D] and 3D inversion algorithms) on liver MR elastography (MRE) and to validate the diagnostic performance of EPI-MRE3D versus conventional GRE-MRE2D for liver fibrosis staging. Materials and Methods: Three MRE methods (EPI-MRE3D, EPI-MRE2D, and GRE-MRE2D) were performed on soft and mildly stiff phantoms and 58 patients with chronic liver disease using a 3 Tesla clinical MRI scanner, and stiffness values were compared among the three methods. A validation study comprised 73 patients with histological liver fibrosis (F0-4, METAVIR system). Areas under the receiver operating characteristic curves (AUCs) and accuracies for diagnosing significant fibrosis (F3-4) and cirrhosis (F4) were compared between EPI-MRE3D and GRE-MRE2D. Results: Stiffness values of the soft and mildly stiff phantoms were 2.4 kPa and 4.0 kPa by EPI-MRE3D; 2.6 kPa and 4.2 kPa by EPI-MRE2D; and 2.7 kPa and 4.2 kPa by GRE-MRE2D. In patients, EPI-MRE3D provided significantly lower stiffness values than other methods (P<0.001). However, there was no significant difference between GRE-MRE2D and EPI-MRE2D (P=0.12). The AUCs and accuracies of EPI-MRE3D and GRE-MRE2D were statistically equivalent in the diagnoses of significant fibrosis (F3-4) and cirrhosis (F4) (all P<0.005). Conclusion: EPI-MRE3D showed modestly lower liver stiffness values than conventional GRE-MRE2D. The diagnostic performances of EPI-MRE3D and GRE-MRE2D were equivalent for liver fibrosis staging.

AB - Purpose: To evaluate the effect of imaging sequence (spin-echo echo-planar imaging [EPI] and gradient-echo [GRE]) and postprocessing method (two-dimensional [2D] and 3D inversion algorithms) on liver MR elastography (MRE) and to validate the diagnostic performance of EPI-MRE3D versus conventional GRE-MRE2D for liver fibrosis staging. Materials and Methods: Three MRE methods (EPI-MRE3D, EPI-MRE2D, and GRE-MRE2D) were performed on soft and mildly stiff phantoms and 58 patients with chronic liver disease using a 3 Tesla clinical MRI scanner, and stiffness values were compared among the three methods. A validation study comprised 73 patients with histological liver fibrosis (F0-4, METAVIR system). Areas under the receiver operating characteristic curves (AUCs) and accuracies for diagnosing significant fibrosis (F3-4) and cirrhosis (F4) were compared between EPI-MRE3D and GRE-MRE2D. Results: Stiffness values of the soft and mildly stiff phantoms were 2.4 kPa and 4.0 kPa by EPI-MRE3D; 2.6 kPa and 4.2 kPa by EPI-MRE2D; and 2.7 kPa and 4.2 kPa by GRE-MRE2D. In patients, EPI-MRE3D provided significantly lower stiffness values than other methods (P<0.001). However, there was no significant difference between GRE-MRE2D and EPI-MRE2D (P=0.12). The AUCs and accuracies of EPI-MRE3D and GRE-MRE2D were statistically equivalent in the diagnoses of significant fibrosis (F3-4) and cirrhosis (F4) (all P<0.005). Conclusion: EPI-MRE3D showed modestly lower liver stiffness values than conventional GRE-MRE2D. The diagnostic performances of EPI-MRE3D and GRE-MRE2D were equivalent for liver fibrosis staging.

KW - Echo planar imaging (EPI)

KW - Gradient-echo imaging (GRE)

KW - Liver fibrosis staging

KW - Magnetic resonance elastography (MRE)

KW - Three-dimensional postprocessing

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