Comparison of calculations to estimate gastric emptying half-time of solids in humans

A. R. Zinsmeister, A. E. Bharucha, M. Camilleri

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Abstract

Background Measuring solid gastric emptying (GE) at 4h is used to identify gastroparesis. GE half-time (GE T1/2) is useful to assess overall and early GE. Aim To examine the validity of hourly imaging as a measurement of GE T1/2 compared with estimates from more detailed imaging. Methods 155 human subjects (99 female, 56 male) underwent scintigraphic GE of a solid-liquid meal. We calculated the GE T1/2 using linear interpolation based on a full set of abdominal images obtained over 4h, and the GE T1/2 based on images at 1, 2, 3, and 4h after the meal with interpolation of data. Key Results Differences in GE T1/2 values (entire set of scan times compared with just the hourly scans) were small [overall median (5th, 95th percentiles)=-0.2[-7.5, 4.6] min] with slightly greater differences in males compared with females. The agreement between the two methods was very high [concordance correlation coefficient (CCC) (95% CI)=0.993 (0.990, 0.995)] and a Bland-Altman plot indicated the variation in the results between the two methods did not change appreciably across the range of GE studied (within ±10min for all but four subjects). Calculated GE T1/2 values, omitting the 3-h data from the hourly measurements, were associated with similar high accuracy overall and for fast GE, but were less accurate with slow GE. Conclusions & Inferences Results of GE T1/2 solids, using hourly imaging over 4h, are accurate in the range 75-235min which reflects the typical range of GE of solids in health and disease.

Original languageEnglish (US)
Pages (from-to)1142-1145
Number of pages4
JournalNeurogastroenterology and Motility
Volume24
Issue number12
DOIs
StatePublished - Dec 1 2012

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Keywords

  • Gastric emptying
  • Scintigraphy
  • Statistical analysis

ASJC Scopus subject areas

  • Physiology
  • Endocrine and Autonomic Systems
  • Gastroenterology

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