Comparison at a synthetic antithrombin III-binding pentasaccharide and standard heparin as an adjunct to coronary thrombolysis

Sorin V. Pislaru, Cristina Pislaru, Xu Zhu, Jef Arnout, Tony Stassen, Philippe Vanhove, Jean Marc Herbert, Dirk G. Meuleman, Frans Van De Werf

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19 Scopus citations

Abstract

The effects on alteplase-induced thrombolysis of the synthetic ATIII-binding pentasaccharide SR90107A/ORG 31540 (synthetic pentasaccharide, SP) and of standard heparin (SH) were compared in a copper coil model of coronary artery thrombosis in 6 groups of 10 dogs. After 1 h of occlusion, all animals received intravenously alteplase and aspirin, and were randomly assigned to a 2 h infusion of either saline, or one of two doses of SH (100 IU/kg bolus plus 50 IU/kg/h infusion, or 200 IU/kg bolus plus 100 IU/kg/h infusion), or one of three doses of SP (100 nmol/kg bolus plus 50 nmol/kg/h infusion, 200 nmol/kg bolus plus 100 nmol/kg/h infusion, or 400 nmol/kg bolus plus 200 nmol/kg/h infusion). Coronary angiography was performed every 10 min for 4 h. Appropriate doses of SP and SH enhanced alteplase-induced thrombolysis to a similar extent. In contrast, SP was devoid of any anti-IIa activity or aPTT prolongation.

Original languageEnglish (US)
Pages (from-to)1130-1135
Number of pages6
JournalThrombosis and Haemostasis
Volume79
Issue number6
DOIs
StatePublished - 1998

ASJC Scopus subject areas

  • Hematology

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    Pislaru, S. V., Pislaru, C., Zhu, X., Arnout, J., Stassen, T., Vanhove, P., Herbert, J. M., Meuleman, D. G., & Van De Werf, F. (1998). Comparison at a synthetic antithrombin III-binding pentasaccharide and standard heparin as an adjunct to coronary thrombolysis. Thrombosis and Haemostasis, 79(6), 1130-1135. https://doi.org/10.1055/s-0037-1615029