Comparison at a synthetic antithrombin III-binding pentasaccharide and standard heparin as an adjunct to coronary thrombolysis

Sorin V. Pislaru, Cristina D Pislaru, Xu Zhu, Jef Arnout, Tony Stassen, Philippe Vanhove, Jean Marc Herbert, Dirk G. Meuleman, Frans Van De Werf

Research output: Contribution to journalArticle

19 Citations (Scopus)

Abstract

The effects on alteplase-induced thrombolysis of the synthetic ATIII-binding pentasaccharide SR90107A/ORG 31540 (synthetic pentasaccharide, SP) and of standard heparin (SH) were compared in a copper coil model of coronary artery thrombosis in 6 groups of 10 dogs. After 1 h of occlusion, all animals received intravenously alteplase and aspirin, and were randomly assigned to a 2 h infusion of either saline, or one of two doses of SH (100 IU/kg bolus plus 50 IU/kg/h infusion, or 200 IU/kg bolus plus 100 IU/kg/h infusion), or one of three doses of SP (100 nmol/kg bolus plus 50 nmol/kg/h infusion, 200 nmol/kg bolus plus 100 nmol/kg/h infusion, or 400 nmol/kg bolus plus 200 nmol/kg/h infusion). Coronary angiography was performed every 10 min for 4 h. Appropriate doses of SP and SH enhanced alteplase-induced thrombolysis to a similar extent. In contrast, SP was devoid of any anti-IIa activity or aPTT prolongation.

Original languageEnglish (US)
Pages (from-to)1130-1135
Number of pages6
JournalThrombosis and Haemostasis
Volume79
Issue number6
StatePublished - 1998
Externally publishedYes

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Antithrombin III
Tissue Plasminogen Activator
Coronary Thrombosis
Coronary Angiography
Aspirin
Heparin
Copper
Coronary Vessels
Dogs
IC 831423

ASJC Scopus subject areas

  • Hematology

Cite this

Pislaru, S. V., Pislaru, C. D., Zhu, X., Arnout, J., Stassen, T., Vanhove, P., ... Van De Werf, F. (1998). Comparison at a synthetic antithrombin III-binding pentasaccharide and standard heparin as an adjunct to coronary thrombolysis. Thrombosis and Haemostasis, 79(6), 1130-1135.

Comparison at a synthetic antithrombin III-binding pentasaccharide and standard heparin as an adjunct to coronary thrombolysis. / Pislaru, Sorin V.; Pislaru, Cristina D; Zhu, Xu; Arnout, Jef; Stassen, Tony; Vanhove, Philippe; Herbert, Jean Marc; Meuleman, Dirk G.; Van De Werf, Frans.

In: Thrombosis and Haemostasis, Vol. 79, No. 6, 1998, p. 1130-1135.

Research output: Contribution to journalArticle

Pislaru, SV, Pislaru, CD, Zhu, X, Arnout, J, Stassen, T, Vanhove, P, Herbert, JM, Meuleman, DG & Van De Werf, F 1998, 'Comparison at a synthetic antithrombin III-binding pentasaccharide and standard heparin as an adjunct to coronary thrombolysis', Thrombosis and Haemostasis, vol. 79, no. 6, pp. 1130-1135.
Pislaru, Sorin V. ; Pislaru, Cristina D ; Zhu, Xu ; Arnout, Jef ; Stassen, Tony ; Vanhove, Philippe ; Herbert, Jean Marc ; Meuleman, Dirk G. ; Van De Werf, Frans. / Comparison at a synthetic antithrombin III-binding pentasaccharide and standard heparin as an adjunct to coronary thrombolysis. In: Thrombosis and Haemostasis. 1998 ; Vol. 79, No. 6. pp. 1130-1135.
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