Comparative diagnostic accuracy of contrast-enhanced MRI and 18F-FDOPA PET-CT in recurrent glioma

Sellam Karunanithi, Punit Sharma, Abhishek Kumar, Bangkim Chandra Khangembam, Guru Pada Bandopadhyaya, Rakesh Kumar, Ajit Goenka, Deepak Kumar Gupta, Arun Malhotra, Chandrasekhar Bal

Research output: Contribution to journalArticle

25 Citations (Scopus)

Abstract

Objectives: To compare the diagnostic accuracy of contrast enhanced magnetic resonance imaging (Ce-MRI) and 18F-fluorodopa ( 18F-FDOPA) positron emission tomography (PET)-computed tomography (CT) for detecting recurrent glioma. Methods: In this prospective study, 35 patients (age, 36.62 ± 0.86 years; 80 % male) with histopathologically proven glioma with clinical suspicion of recurrence were evaluated using Ce-MRI and 18F-FDOPA PET-CT. 18F-FDOPA PET-CT images were evaluated qualitatively and semi-quantitatively. Combination of clinical follow-up (minimum 1 year), repeat imaging and/or biopsy (when available) was taken as the reference standard. Results: Based on the reference standard, 26 patients were positive and nine were negative for recurrence. The sensitivity, specificity and accuracy of Ce-MRI were 92.3 %, 44.4 % and 80 % respectively, whereas those of 18F-FDOPA PET-CT were 100 %, 88.89 % and 97.1 % respectively. Results of Ce-MRI and 18F-FDOPA PET-CT were concordant in 74.3 % (29/35) and discordant in 17.1 % of patients (6/35). On McNemar analysis the difference was not statistically significant overall (P = 0.687), for high-grade tumour (P = 0.5) or low-grade tumours (P = 1.0). However, 18F-FDOPA PET-CT was more specific than Ce-MRI overall (P = 0.0002), for high-grade tumour (P = 0.006) and low-grade tumours (P = 0.004). Conclusion: F-FDOPA PET-CT shows a high but comparable diagnostic accuracy to Ce-MRI for the detection of recurrent glioma. However, it is more specific than Ce-MRI. Key Points: • Recurrent glioma in the postoperative site remains a diagnostic dilemma. • 18 F-FDOPA PET-CT shows high diagnostic accuracy for detecting recurrent glioma. • Diagnostic accuracies for 18 F-FDOPA PET-CT and contrast enhanced MRI are comparable. • However, 18 F-FDOPA PET-CT is more specific than Ce-MRI for recurrent glioma.

Original languageEnglish (US)
Pages (from-to)2628-2635
Number of pages8
JournalEuropean radiology
Volume23
Issue number9
DOIs
StatePublished - Sep 1 2013
Externally publishedYes

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Glioma
Magnetic Resonance Imaging
Neoplasms
Positron Emission Tomography Computed Tomography
fluorodopa F 18
Recurrence
Prospective Studies
Biopsy
Sensitivity and Specificity

Keywords

  • F-FDOPA
  • Glioma
  • MRI
  • PET-CT
  • Recurrence

ASJC Scopus subject areas

  • Radiology Nuclear Medicine and imaging

Cite this

Karunanithi, S., Sharma, P., Kumar, A., Khangembam, B. C., Bandopadhyaya, G. P., Kumar, R., ... Bal, C. (2013). Comparative diagnostic accuracy of contrast-enhanced MRI and 18F-FDOPA PET-CT in recurrent glioma. European radiology, 23(9), 2628-2635. https://doi.org/10.1007/s00330-013-2838-6

Comparative diagnostic accuracy of contrast-enhanced MRI and 18F-FDOPA PET-CT in recurrent glioma. / Karunanithi, Sellam; Sharma, Punit; Kumar, Abhishek; Khangembam, Bangkim Chandra; Bandopadhyaya, Guru Pada; Kumar, Rakesh; Goenka, Ajit; Gupta, Deepak Kumar; Malhotra, Arun; Bal, Chandrasekhar.

In: European radiology, Vol. 23, No. 9, 01.09.2013, p. 2628-2635.

Research output: Contribution to journalArticle

Karunanithi, S, Sharma, P, Kumar, A, Khangembam, BC, Bandopadhyaya, GP, Kumar, R, Goenka, A, Gupta, DK, Malhotra, A & Bal, C 2013, 'Comparative diagnostic accuracy of contrast-enhanced MRI and 18F-FDOPA PET-CT in recurrent glioma', European radiology, vol. 23, no. 9, pp. 2628-2635. https://doi.org/10.1007/s00330-013-2838-6
Karunanithi S, Sharma P, Kumar A, Khangembam BC, Bandopadhyaya GP, Kumar R et al. Comparative diagnostic accuracy of contrast-enhanced MRI and 18F-FDOPA PET-CT in recurrent glioma. European radiology. 2013 Sep 1;23(9):2628-2635. https://doi.org/10.1007/s00330-013-2838-6
Karunanithi, Sellam ; Sharma, Punit ; Kumar, Abhishek ; Khangembam, Bangkim Chandra ; Bandopadhyaya, Guru Pada ; Kumar, Rakesh ; Goenka, Ajit ; Gupta, Deepak Kumar ; Malhotra, Arun ; Bal, Chandrasekhar. / Comparative diagnostic accuracy of contrast-enhanced MRI and 18F-FDOPA PET-CT in recurrent glioma. In: European radiology. 2013 ; Vol. 23, No. 9. pp. 2628-2635.
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abstract = "Objectives: To compare the diagnostic accuracy of contrast enhanced magnetic resonance imaging (Ce-MRI) and 18F-fluorodopa ( 18F-FDOPA) positron emission tomography (PET)-computed tomography (CT) for detecting recurrent glioma. Methods: In this prospective study, 35 patients (age, 36.62 ± 0.86 years; 80 {\%} male) with histopathologically proven glioma with clinical suspicion of recurrence were evaluated using Ce-MRI and 18F-FDOPA PET-CT. 18F-FDOPA PET-CT images were evaluated qualitatively and semi-quantitatively. Combination of clinical follow-up (minimum 1 year), repeat imaging and/or biopsy (when available) was taken as the reference standard. Results: Based on the reference standard, 26 patients were positive and nine were negative for recurrence. The sensitivity, specificity and accuracy of Ce-MRI were 92.3 {\%}, 44.4 {\%} and 80 {\%} respectively, whereas those of 18F-FDOPA PET-CT were 100 {\%}, 88.89 {\%} and 97.1 {\%} respectively. Results of Ce-MRI and 18F-FDOPA PET-CT were concordant in 74.3 {\%} (29/35) and discordant in 17.1 {\%} of patients (6/35). On McNemar analysis the difference was not statistically significant overall (P = 0.687), for high-grade tumour (P = 0.5) or low-grade tumours (P = 1.0). However, 18F-FDOPA PET-CT was more specific than Ce-MRI overall (P = 0.0002), for high-grade tumour (P = 0.006) and low-grade tumours (P = 0.004). Conclusion: F-FDOPA PET-CT shows a high but comparable diagnostic accuracy to Ce-MRI for the detection of recurrent glioma. However, it is more specific than Ce-MRI. Key Points: • Recurrent glioma in the postoperative site remains a diagnostic dilemma. • 18 F-FDOPA PET-CT shows high diagnostic accuracy for detecting recurrent glioma. • Diagnostic accuracies for 18 F-FDOPA PET-CT and contrast enhanced MRI are comparable. • However, 18 F-FDOPA PET-CT is more specific than Ce-MRI for recurrent glioma.",
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T1 - Comparative diagnostic accuracy of contrast-enhanced MRI and 18F-FDOPA PET-CT in recurrent glioma

AU - Karunanithi, Sellam

AU - Sharma, Punit

AU - Kumar, Abhishek

AU - Khangembam, Bangkim Chandra

AU - Bandopadhyaya, Guru Pada

AU - Kumar, Rakesh

AU - Goenka, Ajit

AU - Gupta, Deepak Kumar

AU - Malhotra, Arun

AU - Bal, Chandrasekhar

PY - 2013/9/1

Y1 - 2013/9/1

N2 - Objectives: To compare the diagnostic accuracy of contrast enhanced magnetic resonance imaging (Ce-MRI) and 18F-fluorodopa ( 18F-FDOPA) positron emission tomography (PET)-computed tomography (CT) for detecting recurrent glioma. Methods: In this prospective study, 35 patients (age, 36.62 ± 0.86 years; 80 % male) with histopathologically proven glioma with clinical suspicion of recurrence were evaluated using Ce-MRI and 18F-FDOPA PET-CT. 18F-FDOPA PET-CT images were evaluated qualitatively and semi-quantitatively. Combination of clinical follow-up (minimum 1 year), repeat imaging and/or biopsy (when available) was taken as the reference standard. Results: Based on the reference standard, 26 patients were positive and nine were negative for recurrence. The sensitivity, specificity and accuracy of Ce-MRI were 92.3 %, 44.4 % and 80 % respectively, whereas those of 18F-FDOPA PET-CT were 100 %, 88.89 % and 97.1 % respectively. Results of Ce-MRI and 18F-FDOPA PET-CT were concordant in 74.3 % (29/35) and discordant in 17.1 % of patients (6/35). On McNemar analysis the difference was not statistically significant overall (P = 0.687), for high-grade tumour (P = 0.5) or low-grade tumours (P = 1.0). However, 18F-FDOPA PET-CT was more specific than Ce-MRI overall (P = 0.0002), for high-grade tumour (P = 0.006) and low-grade tumours (P = 0.004). Conclusion: F-FDOPA PET-CT shows a high but comparable diagnostic accuracy to Ce-MRI for the detection of recurrent glioma. However, it is more specific than Ce-MRI. Key Points: • Recurrent glioma in the postoperative site remains a diagnostic dilemma. • 18 F-FDOPA PET-CT shows high diagnostic accuracy for detecting recurrent glioma. • Diagnostic accuracies for 18 F-FDOPA PET-CT and contrast enhanced MRI are comparable. • However, 18 F-FDOPA PET-CT is more specific than Ce-MRI for recurrent glioma.

AB - Objectives: To compare the diagnostic accuracy of contrast enhanced magnetic resonance imaging (Ce-MRI) and 18F-fluorodopa ( 18F-FDOPA) positron emission tomography (PET)-computed tomography (CT) for detecting recurrent glioma. Methods: In this prospective study, 35 patients (age, 36.62 ± 0.86 years; 80 % male) with histopathologically proven glioma with clinical suspicion of recurrence were evaluated using Ce-MRI and 18F-FDOPA PET-CT. 18F-FDOPA PET-CT images were evaluated qualitatively and semi-quantitatively. Combination of clinical follow-up (minimum 1 year), repeat imaging and/or biopsy (when available) was taken as the reference standard. Results: Based on the reference standard, 26 patients were positive and nine were negative for recurrence. The sensitivity, specificity and accuracy of Ce-MRI were 92.3 %, 44.4 % and 80 % respectively, whereas those of 18F-FDOPA PET-CT were 100 %, 88.89 % and 97.1 % respectively. Results of Ce-MRI and 18F-FDOPA PET-CT were concordant in 74.3 % (29/35) and discordant in 17.1 % of patients (6/35). On McNemar analysis the difference was not statistically significant overall (P = 0.687), for high-grade tumour (P = 0.5) or low-grade tumours (P = 1.0). However, 18F-FDOPA PET-CT was more specific than Ce-MRI overall (P = 0.0002), for high-grade tumour (P = 0.006) and low-grade tumours (P = 0.004). Conclusion: F-FDOPA PET-CT shows a high but comparable diagnostic accuracy to Ce-MRI for the detection of recurrent glioma. However, it is more specific than Ce-MRI. Key Points: • Recurrent glioma in the postoperative site remains a diagnostic dilemma. • 18 F-FDOPA PET-CT shows high diagnostic accuracy for detecting recurrent glioma. • Diagnostic accuracies for 18 F-FDOPA PET-CT and contrast enhanced MRI are comparable. • However, 18 F-FDOPA PET-CT is more specific than Ce-MRI for recurrent glioma.

KW - F-FDOPA

KW - Glioma

KW - MRI

KW - PET-CT

KW - Recurrence

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