Common variants in the obesity-associated genes FTO and MC4R are not associated with risk of colorectal cancer

Baiyu Yang, Aaron P. Thrift, Jane C. Figueiredo, Mark A. Jenkins, Fredrick R. Schumacher, David V. Conti, Yi Lin, Aung Ko Win, Paul John Limburg, Sonja I. Berndt, Hermann Brenner, Andrew T. Chan, Jenny Chang-Claude, Michael Hoffmeister, Thomas J. Hudson, Loïc Le Marchand, Polly A. Newcomb, Martha L. Slattery, Emily White, Ulrike PetersGraham Casey, Peter T. Campbell

Research output: Contribution to journalArticle

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Abstract

Background Obesity is a convincing risk factor for colorectal cancer. Genetic variants in or near FTO and MC4R are consistently associated with body mass index and other body size measures, but whether they are also associated with colorectal cancer risk is unclear. Methods In the discovery stage, we tested associations of 677 FTO and 323 MC4R single nucleotide polymorphisms (SNPs) 100 kb upstream and 300 kb downstream from each respective locus with risk of colorectal cancer in data from the Colon Cancer Family Registry (CCFR: 1960 cases; 1777 controls). Next, all SNPs that were nominally statistically significant (p < 0.05) in the discovery stage were included in replication analyses in data from the Genetics and Epidemiology of Colorectal Cancer Consortium (GECCO: 9716 cases; 9844 controls). Results In the discovery stage, 43 FTO variants and 18 MC4R variants were associated with colorectal cancer risk (p < 0.05). No SNPs remained statistically significant in the replication analysis after accounting for multiple comparisons. Conclusion We found no evidence that individual variants in or near the obesity-related genes FTO and MC4R are associated with risk of colorectal cancer.

Original languageEnglish (US)
Pages (from-to)1-4
Number of pages4
JournalCancer Epidemiology
Volume44
DOIs
StatePublished - Oct 1 2016

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Colorectal Neoplasms
Obesity
Genes
Single Nucleotide Polymorphism
Body Weights and Measures
Molecular Epidemiology
Body Size
Colonic Neoplasms
Registries
Body Mass Index

Keywords

  • Case-control study
  • Colorectal cancer
  • Genetic variants
  • Obesity

ASJC Scopus subject areas

  • Cancer Research
  • Oncology
  • Epidemiology

Cite this

Yang, B., Thrift, A. P., Figueiredo, J. C., Jenkins, M. A., Schumacher, F. R., Conti, D. V., ... Campbell, P. T. (2016). Common variants in the obesity-associated genes FTO and MC4R are not associated with risk of colorectal cancer. Cancer Epidemiology, 44, 1-4. https://doi.org/10.1016/j.canep.2016.07.003

Common variants in the obesity-associated genes FTO and MC4R are not associated with risk of colorectal cancer. / Yang, Baiyu; Thrift, Aaron P.; Figueiredo, Jane C.; Jenkins, Mark A.; Schumacher, Fredrick R.; Conti, David V.; Lin, Yi; Win, Aung Ko; Limburg, Paul John; Berndt, Sonja I.; Brenner, Hermann; Chan, Andrew T.; Chang-Claude, Jenny; Hoffmeister, Michael; Hudson, Thomas J.; Marchand, Loïc Le; Newcomb, Polly A.; Slattery, Martha L.; White, Emily; Peters, Ulrike; Casey, Graham; Campbell, Peter T.

In: Cancer Epidemiology, Vol. 44, 01.10.2016, p. 1-4.

Research output: Contribution to journalArticle

Yang, B, Thrift, AP, Figueiredo, JC, Jenkins, MA, Schumacher, FR, Conti, DV, Lin, Y, Win, AK, Limburg, PJ, Berndt, SI, Brenner, H, Chan, AT, Chang-Claude, J, Hoffmeister, M, Hudson, TJ, Marchand, LL, Newcomb, PA, Slattery, ML, White, E, Peters, U, Casey, G & Campbell, PT 2016, 'Common variants in the obesity-associated genes FTO and MC4R are not associated with risk of colorectal cancer', Cancer Epidemiology, vol. 44, pp. 1-4. https://doi.org/10.1016/j.canep.2016.07.003
Yang, Baiyu ; Thrift, Aaron P. ; Figueiredo, Jane C. ; Jenkins, Mark A. ; Schumacher, Fredrick R. ; Conti, David V. ; Lin, Yi ; Win, Aung Ko ; Limburg, Paul John ; Berndt, Sonja I. ; Brenner, Hermann ; Chan, Andrew T. ; Chang-Claude, Jenny ; Hoffmeister, Michael ; Hudson, Thomas J. ; Marchand, Loïc Le ; Newcomb, Polly A. ; Slattery, Martha L. ; White, Emily ; Peters, Ulrike ; Casey, Graham ; Campbell, Peter T. / Common variants in the obesity-associated genes FTO and MC4R are not associated with risk of colorectal cancer. In: Cancer Epidemiology. 2016 ; Vol. 44. pp. 1-4.
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abstract = "Background Obesity is a convincing risk factor for colorectal cancer. Genetic variants in or near FTO and MC4R are consistently associated with body mass index and other body size measures, but whether they are also associated with colorectal cancer risk is unclear. Methods In the discovery stage, we tested associations of 677 FTO and 323 MC4R single nucleotide polymorphisms (SNPs) 100 kb upstream and 300 kb downstream from each respective locus with risk of colorectal cancer in data from the Colon Cancer Family Registry (CCFR: 1960 cases; 1777 controls). Next, all SNPs that were nominally statistically significant (p < 0.05) in the discovery stage were included in replication analyses in data from the Genetics and Epidemiology of Colorectal Cancer Consortium (GECCO: 9716 cases; 9844 controls). Results In the discovery stage, 43 FTO variants and 18 MC4R variants were associated with colorectal cancer risk (p < 0.05). No SNPs remained statistically significant in the replication analysis after accounting for multiple comparisons. Conclusion We found no evidence that individual variants in or near the obesity-related genes FTO and MC4R are associated with risk of colorectal cancer.",
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AU - Yang, Baiyu

AU - Thrift, Aaron P.

AU - Figueiredo, Jane C.

AU - Jenkins, Mark A.

AU - Schumacher, Fredrick R.

AU - Conti, David V.

AU - Lin, Yi

AU - Win, Aung Ko

AU - Limburg, Paul John

AU - Berndt, Sonja I.

AU - Brenner, Hermann

AU - Chan, Andrew T.

AU - Chang-Claude, Jenny

AU - Hoffmeister, Michael

AU - Hudson, Thomas J.

AU - Marchand, Loïc Le

AU - Newcomb, Polly A.

AU - Slattery, Martha L.

AU - White, Emily

AU - Peters, Ulrike

AU - Casey, Graham

AU - Campbell, Peter T.

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N2 - Background Obesity is a convincing risk factor for colorectal cancer. Genetic variants in or near FTO and MC4R are consistently associated with body mass index and other body size measures, but whether they are also associated with colorectal cancer risk is unclear. Methods In the discovery stage, we tested associations of 677 FTO and 323 MC4R single nucleotide polymorphisms (SNPs) 100 kb upstream and 300 kb downstream from each respective locus with risk of colorectal cancer in data from the Colon Cancer Family Registry (CCFR: 1960 cases; 1777 controls). Next, all SNPs that were nominally statistically significant (p < 0.05) in the discovery stage were included in replication analyses in data from the Genetics and Epidemiology of Colorectal Cancer Consortium (GECCO: 9716 cases; 9844 controls). Results In the discovery stage, 43 FTO variants and 18 MC4R variants were associated with colorectal cancer risk (p < 0.05). No SNPs remained statistically significant in the replication analysis after accounting for multiple comparisons. Conclusion We found no evidence that individual variants in or near the obesity-related genes FTO and MC4R are associated with risk of colorectal cancer.

AB - Background Obesity is a convincing risk factor for colorectal cancer. Genetic variants in or near FTO and MC4R are consistently associated with body mass index and other body size measures, but whether they are also associated with colorectal cancer risk is unclear. Methods In the discovery stage, we tested associations of 677 FTO and 323 MC4R single nucleotide polymorphisms (SNPs) 100 kb upstream and 300 kb downstream from each respective locus with risk of colorectal cancer in data from the Colon Cancer Family Registry (CCFR: 1960 cases; 1777 controls). Next, all SNPs that were nominally statistically significant (p < 0.05) in the discovery stage were included in replication analyses in data from the Genetics and Epidemiology of Colorectal Cancer Consortium (GECCO: 9716 cases; 9844 controls). Results In the discovery stage, 43 FTO variants and 18 MC4R variants were associated with colorectal cancer risk (p < 0.05). No SNPs remained statistically significant in the replication analysis after accounting for multiple comparisons. Conclusion We found no evidence that individual variants in or near the obesity-related genes FTO and MC4R are associated with risk of colorectal cancer.

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