Common variants in the obesity-associated genes FTO and MC4R are not associated with risk of colorectal cancer

Baiyu Yang; Aaron P. Thrift; Jane C. Figueiredo; Mark A. Jenkins; Fredrick R. Schumacher; David V. Conti; Yi Lin; Aung Ko Win; Paul J. Limburg; Sonja I. Berndt; Hermann Brenner; Andrew T. Chan; Jenny Chang-Claude; Michael Hoffmeister; Thomas J. Hudson; Loïc Le Marchand; Polly A. Newcomb; Martha L. Slattery; Emily White; Ulrike Peters; Graham Casey; Peter T. Campbell

doi:10.1016/j.canep.2016.07.003

Common variants in the obesity-associated genes FTO and MC4R are not associated with risk of colorectal cancer

Baiyu Yang, Aaron P. Thrift, Jane C. Figueiredo, Mark A. Jenkins, Fredrick R. Schumacher, David V. Conti, Yi Lin, Aung Ko Win, Paul J. Limburg, Sonja I. Berndt, Hermann Brenner, Andrew T. Chan, Jenny Chang-Claude, Michael Hoffmeister, Thomas J. Hudson, Loïc Le Marchand, Polly A. Newcomb, Martha L. Slattery, Emily White, Ulrike PetersGraham Casey, Peter T. Campbell

Gastroenterology and Hepatology

Research output: Contribution to journal › Article › peer-review

8 Scopus citations

Abstract

Background Obesity is a convincing risk factor for colorectal cancer. Genetic variants in or near FTO and MC4R are consistently associated with body mass index and other body size measures, but whether they are also associated with colorectal cancer risk is unclear. Methods In the discovery stage, we tested associations of 677 FTO and 323 MC4R single nucleotide polymorphisms (SNPs) 100 kb upstream and 300 kb downstream from each respective locus with risk of colorectal cancer in data from the Colon Cancer Family Registry (CCFR: 1960 cases; 1777 controls). Next, all SNPs that were nominally statistically significant (p < 0.05) in the discovery stage were included in replication analyses in data from the Genetics and Epidemiology of Colorectal Cancer Consortium (GECCO: 9716 cases; 9844 controls). Results In the discovery stage, 43 FTO variants and 18 MC4R variants were associated with colorectal cancer risk (p < 0.05). No SNPs remained statistically significant in the replication analysis after accounting for multiple comparisons. Conclusion We found no evidence that individual variants in or near the obesity-related genes FTO and MC4R are associated with risk of colorectal cancer.

Original language	English (US)
Pages (from-to)	1-4
Number of pages	4
Journal	Cancer Epidemiology
Volume	44
DOIs	https://doi.org/10.1016/j.canep.2016.07.003
State	Published - Oct 1 2016

Keywords

Case-control study
Colorectal cancer
Genetic variants
Obesity

ASJC Scopus subject areas

Epidemiology
Oncology
Cancer Research

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10.1016/j.canep.2016.07.003

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Yang, B., Thrift, A. P., Figueiredo, J. C., Jenkins, M. A., Schumacher, F. R., Conti, D. V., Lin, Y., Win, A. K., Limburg, P. J., Berndt, S. I., Brenner, H., Chan, A. T., Chang-Claude, J., Hoffmeister, M., Hudson, T. J., Marchand, L. L., Newcomb, P. A., Slattery, M. L., White, E., ... Campbell, P. T. (2016). Common variants in the obesity-associated genes FTO and MC4R are not associated with risk of colorectal cancer. Cancer Epidemiology, 44, 1-4. https://doi.org/10.1016/j.canep.2016.07.003

Yang, B, Thrift, AP, Figueiredo, JC, Jenkins, MA, Schumacher, FR, Conti, DV, Lin, Y, Win, AK, Limburg, PJ, Berndt, SI, Brenner, H, Chan, AT, Chang-Claude, J, Hoffmeister, M, Hudson, TJ, Marchand, LL, Newcomb, PA, Slattery, ML, White, E, Peters, U, Casey, G & Campbell, PT 2016, 'Common variants in the obesity-associated genes FTO and MC4R are not associated with risk of colorectal cancer', Cancer Epidemiology, vol. 44, pp. 1-4. https://doi.org/10.1016/j.canep.2016.07.003

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title = "Common variants in the obesity-associated genes FTO and MC4R are not associated with risk of colorectal cancer",

abstract = "Background Obesity is a convincing risk factor for colorectal cancer. Genetic variants in or near FTO and MC4R are consistently associated with body mass index and other body size measures, but whether they are also associated with colorectal cancer risk is unclear. Methods In the discovery stage, we tested associations of 677 FTO and 323 MC4R single nucleotide polymorphisms (SNPs) 100 kb upstream and 300 kb downstream from each respective locus with risk of colorectal cancer in data from the Colon Cancer Family Registry (CCFR: 1960 cases; 1777 controls). Next, all SNPs that were nominally statistically significant (p < 0.05) in the discovery stage were included in replication analyses in data from the Genetics and Epidemiology of Colorectal Cancer Consortium (GECCO: 9716 cases; 9844 controls). Results In the discovery stage, 43 FTO variants and 18 MC4R variants were associated with colorectal cancer risk (p < 0.05). No SNPs remained statistically significant in the replication analysis after accounting for multiple comparisons. Conclusion We found no evidence that individual variants in or near the obesity-related genes FTO and MC4R are associated with risk of colorectal cancer.",

keywords = "Case-control study, Colorectal cancer, Genetic variants, Obesity",

author = "Baiyu Yang and Thrift, {Aaron P.} and Figueiredo, {Jane C.} and Jenkins, {Mark A.} and Schumacher, {Fredrick R.} and Conti, {David V.} and Yi Lin and Win, {Aung Ko} and Limburg, {Paul J.} and Berndt, {Sonja I.} and Hermann Brenner and Chan, {Andrew T.} and Jenny Chang-Claude and Michael Hoffmeister and Hudson, {Thomas J.} and Marchand, {Lo{\"i}c Le} and Newcomb, {Polly A.} and Slattery, {Martha L.} and Emily White and Ulrike Peters and Graham Casey and Campbell, {Peter T.}",

note = "Publisher Copyright: {\textcopyright} 2016",

year = "2016",

month = oct,

day = "1",

doi = "10.1016/j.canep.2016.07.003",

language = "English (US)",

volume = "44",

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journal = "Cancer Epidemiology",

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T1 - Common variants in the obesity-associated genes FTO and MC4R are not associated with risk of colorectal cancer

AU - Yang, Baiyu

AU - Thrift, Aaron P.

AU - Figueiredo, Jane C.

AU - Jenkins, Mark A.

AU - Schumacher, Fredrick R.

AU - Conti, David V.

AU - Lin, Yi

AU - Win, Aung Ko

AU - Limburg, Paul J.

AU - Berndt, Sonja I.

AU - Brenner, Hermann

AU - Chan, Andrew T.

AU - Chang-Claude, Jenny

AU - Hoffmeister, Michael

AU - Hudson, Thomas J.

AU - Marchand, Loïc Le

AU - Newcomb, Polly A.

AU - Slattery, Martha L.

AU - White, Emily

AU - Peters, Ulrike

AU - Casey, Graham

AU - Campbell, Peter T.

PY - 2016/10/1

Y1 - 2016/10/1

N2 - Background Obesity is a convincing risk factor for colorectal cancer. Genetic variants in or near FTO and MC4R are consistently associated with body mass index and other body size measures, but whether they are also associated with colorectal cancer risk is unclear. Methods In the discovery stage, we tested associations of 677 FTO and 323 MC4R single nucleotide polymorphisms (SNPs) 100 kb upstream and 300 kb downstream from each respective locus with risk of colorectal cancer in data from the Colon Cancer Family Registry (CCFR: 1960 cases; 1777 controls). Next, all SNPs that were nominally statistically significant (p < 0.05) in the discovery stage were included in replication analyses in data from the Genetics and Epidemiology of Colorectal Cancer Consortium (GECCO: 9716 cases; 9844 controls). Results In the discovery stage, 43 FTO variants and 18 MC4R variants were associated with colorectal cancer risk (p < 0.05). No SNPs remained statistically significant in the replication analysis after accounting for multiple comparisons. Conclusion We found no evidence that individual variants in or near the obesity-related genes FTO and MC4R are associated with risk of colorectal cancer.

AB - Background Obesity is a convincing risk factor for colorectal cancer. Genetic variants in or near FTO and MC4R are consistently associated with body mass index and other body size measures, but whether they are also associated with colorectal cancer risk is unclear. Methods In the discovery stage, we tested associations of 677 FTO and 323 MC4R single nucleotide polymorphisms (SNPs) 100 kb upstream and 300 kb downstream from each respective locus with risk of colorectal cancer in data from the Colon Cancer Family Registry (CCFR: 1960 cases; 1777 controls). Next, all SNPs that were nominally statistically significant (p < 0.05) in the discovery stage were included in replication analyses in data from the Genetics and Epidemiology of Colorectal Cancer Consortium (GECCO: 9716 cases; 9844 controls). Results In the discovery stage, 43 FTO variants and 18 MC4R variants were associated with colorectal cancer risk (p < 0.05). No SNPs remained statistically significant in the replication analysis after accounting for multiple comparisons. Conclusion We found no evidence that individual variants in or near the obesity-related genes FTO and MC4R are associated with risk of colorectal cancer.

KW - Case-control study

KW - Colorectal cancer

KW - Genetic variants

KW - Obesity

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SN - 1877-7821

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JO - Cancer Epidemiology

JF - Cancer Epidemiology

ER -

Common variants in the obesity-associated genes FTO and MC4R are not associated with risk of colorectal cancer

Abstract

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