Common Kibra alleles are associated with human memory performance

Andreas Papassotiropoulos, Dietrich A. Stephan, Matthew J. Huentelman, Frederic J. Hoerndli, David W. Craig, John V. Pearson, Kim Dung Huynh, Fabienne Brunner, Jason Corneveaux, David Osborne, M. Axel Wollmer, Amanda Aerni, Daniel Coluccia, Jürgen Hänggi, Christian R A Mondadori, Andreas Buchmann, Eric M. Reiman, Richard John Caselli, Katharina Henke, Dominique J F De Quervain

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Abstract

Human memory is a polygenic trait. We performed a genome-wide screen to identify memory-related gene variants. A genomic locus encoding the brain protein KIBRA was significantly associated with memory performance in three independent, cognitively normal cohorts from Switzerland and the United States. Gene expression studies showed that KIBRA was expressed in memory-related brain structures. Functional magnetic resonance imaging detected KIBRA allele-dependent differences in hippocampal activations during memory retrieval. Evidence from these experiments suggests a role for KIBRA in human memory.

Original languageEnglish (US)
Pages (from-to)475-478
Number of pages4
JournalScience
Volume314
Issue number5798
DOIs
StatePublished - Oct 20 2006

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Alleles
Multifactorial Inheritance
Brain
Switzerland
Magnetic Resonance Imaging
Genome
Gene Expression
Genes
Proteins

ASJC Scopus subject areas

  • General

Cite this

Papassotiropoulos, A., Stephan, D. A., Huentelman, M. J., Hoerndli, F. J., Craig, D. W., Pearson, J. V., ... De Quervain, D. J. F. (2006). Common Kibra alleles are associated with human memory performance. Science, 314(5798), 475-478. https://doi.org/10.1126/science.1129837

Common Kibra alleles are associated with human memory performance. / Papassotiropoulos, Andreas; Stephan, Dietrich A.; Huentelman, Matthew J.; Hoerndli, Frederic J.; Craig, David W.; Pearson, John V.; Huynh, Kim Dung; Brunner, Fabienne; Corneveaux, Jason; Osborne, David; Wollmer, M. Axel; Aerni, Amanda; Coluccia, Daniel; Hänggi, Jürgen; Mondadori, Christian R A; Buchmann, Andreas; Reiman, Eric M.; Caselli, Richard John; Henke, Katharina; De Quervain, Dominique J F.

In: Science, Vol. 314, No. 5798, 20.10.2006, p. 475-478.

Research output: Contribution to journalArticle

Papassotiropoulos, A, Stephan, DA, Huentelman, MJ, Hoerndli, FJ, Craig, DW, Pearson, JV, Huynh, KD, Brunner, F, Corneveaux, J, Osborne, D, Wollmer, MA, Aerni, A, Coluccia, D, Hänggi, J, Mondadori, CRA, Buchmann, A, Reiman, EM, Caselli, RJ, Henke, K & De Quervain, DJF 2006, 'Common Kibra alleles are associated with human memory performance', Science, vol. 314, no. 5798, pp. 475-478. https://doi.org/10.1126/science.1129837
Papassotiropoulos A, Stephan DA, Huentelman MJ, Hoerndli FJ, Craig DW, Pearson JV et al. Common Kibra alleles are associated with human memory performance. Science. 2006 Oct 20;314(5798):475-478. https://doi.org/10.1126/science.1129837
Papassotiropoulos, Andreas ; Stephan, Dietrich A. ; Huentelman, Matthew J. ; Hoerndli, Frederic J. ; Craig, David W. ; Pearson, John V. ; Huynh, Kim Dung ; Brunner, Fabienne ; Corneveaux, Jason ; Osborne, David ; Wollmer, M. Axel ; Aerni, Amanda ; Coluccia, Daniel ; Hänggi, Jürgen ; Mondadori, Christian R A ; Buchmann, Andreas ; Reiman, Eric M. ; Caselli, Richard John ; Henke, Katharina ; De Quervain, Dominique J F. / Common Kibra alleles are associated with human memory performance. In: Science. 2006 ; Vol. 314, No. 5798. pp. 475-478.
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