Common Kibra alleles are associated with human memory performance

Andreas Papassotiropoulos; Dietrich A. Stephan; Matthew J. Huentelman; Frederic J. Hoerndli; David W. Craig; John V. Pearson; Kim Dung Huynh; Fabienne Brunner; Jason Corneveaux; David Osborne; M. Axel Wollmer; Amanda Aerni; Daniel Coluccia; Jürgen Hänggi; Christian R.A. Mondadori; Andreas Buchmann; Eric M. Reiman; Richard J. Caselli; Katharina Henke; Dominique J.F. De Quervain

doi:10.1126/science.1129837

Common Kibra alleles are associated with human memory performance

Andreas Papassotiropoulos, Dietrich A. Stephan, Matthew J. Huentelman, Frederic J. Hoerndli, David W. Craig, John V. Pearson, Kim Dung Huynh, Fabienne Brunner, Jason Corneveaux, David Osborne, M. Axel Wollmer, Amanda Aerni, Daniel Coluccia, Jürgen Hänggi, Christian R.A. Mondadori, Andreas Buchmann, Eric M. Reiman, Richard J. Caselli, Katharina Henke, Dominique J.F. De Quervain

Neurology

Research output: Contribution to journal › Article › peer-review

311 Scopus citations

Abstract

Human memory is a polygenic trait. We performed a genome-wide screen to identify memory-related gene variants. A genomic locus encoding the brain protein KIBRA was significantly associated with memory performance in three independent, cognitively normal cohorts from Switzerland and the United States. Gene expression studies showed that KIBRA was expressed in memory-related brain structures. Functional magnetic resonance imaging detected KIBRA allele-dependent differences in hippocampal activations during memory retrieval. Evidence from these experiments suggests a role for KIBRA in human memory.

Original language	English (US)
Pages (from-to)	475-478
Number of pages	4
Journal	Science
Volume	314
Issue number	5798
DOIs	https://doi.org/10.1126/science.1129837
State	Published - Oct 20 2006

ASJC Scopus subject areas

General

Access to Document

10.1126/science.1129837

Cite this

Papassotiropoulos, A., Stephan, D. A., Huentelman, M. J., Hoerndli, F. J., Craig, D. W., Pearson, J. V., Huynh, K. D., Brunner, F., Corneveaux, J., Osborne, D., Wollmer, M. A., Aerni, A., Coluccia, D., Hänggi, J., Mondadori, C. R. A., Buchmann, A., Reiman, E. M., Caselli, R. J., Henke, K., & De Quervain, D. J. F. (2006). Common Kibra alleles are associated with human memory performance. Science, 314(5798), 475-478. https://doi.org/10.1126/science.1129837

Papassotiropoulos, A, Stephan, DA, Huentelman, MJ, Hoerndli, FJ, Craig, DW, Pearson, JV, Huynh, KD, Brunner, F, Corneveaux, J, Osborne, D, Wollmer, MA, Aerni, A, Coluccia, D, Hänggi, J, Mondadori, CRA, Buchmann, A, Reiman, EM, Caselli, RJ, Henke, K & De Quervain, DJF 2006, 'Common Kibra alleles are associated with human memory performance', Science, vol. 314, no. 5798, pp. 475-478. https://doi.org/10.1126/science.1129837

@article{993dc91d43cb497891d09ae9178f3ad5,

title = "Common Kibra alleles are associated with human memory performance",

abstract = "Human memory is a polygenic trait. We performed a genome-wide screen to identify memory-related gene variants. A genomic locus encoding the brain protein KIBRA was significantly associated with memory performance in three independent, cognitively normal cohorts from Switzerland and the United States. Gene expression studies showed that KIBRA was expressed in memory-related brain structures. Functional magnetic resonance imaging detected KIBRA allele-dependent differences in hippocampal activations during memory retrieval. Evidence from these experiments suggests a role for KIBRA in human memory.",

author = "Andreas Papassotiropoulos and Stephan, {Dietrich A.} and Huentelman, {Matthew J.} and Hoerndli, {Frederic J.} and Craig, {David W.} and Pearson, {John V.} and Huynh, {Kim Dung} and Fabienne Brunner and Jason Corneveaux and David Osborne and Wollmer, {M. Axel} and Amanda Aerni and Daniel Coluccia and J{\"u}rgen H{\"a}nggi and Mondadori, {Christian R.A.} and Andreas Buchmann and Reiman, {Eric M.} and Caselli, {Richard J.} and Katharina Henke and {De Quervain}, {Dominique J.F.}",

year = "2006",

month = oct,

day = "20",

doi = "10.1126/science.1129837",

language = "English (US)",

volume = "314",

pages = "475--478",

journal = "Science",

issn = "0036-8075",

publisher = "American Association for the Advancement of Science",

number = "5798",

}

TY - JOUR

T1 - Common Kibra alleles are associated with human memory performance

AU - Papassotiropoulos, Andreas

AU - Stephan, Dietrich A.

AU - Huentelman, Matthew J.

AU - Hoerndli, Frederic J.

AU - Craig, David W.

AU - Pearson, John V.

AU - Huynh, Kim Dung

AU - Brunner, Fabienne

AU - Corneveaux, Jason

AU - Osborne, David

AU - Wollmer, M. Axel

AU - Aerni, Amanda

AU - Coluccia, Daniel

AU - Hänggi, Jürgen

AU - Mondadori, Christian R.A.

AU - Buchmann, Andreas

AU - Reiman, Eric M.

AU - Caselli, Richard J.

AU - Henke, Katharina

AU - De Quervain, Dominique J.F.

PY - 2006/10/20

Y1 - 2006/10/20

N2 - Human memory is a polygenic trait. We performed a genome-wide screen to identify memory-related gene variants. A genomic locus encoding the brain protein KIBRA was significantly associated with memory performance in three independent, cognitively normal cohorts from Switzerland and the United States. Gene expression studies showed that KIBRA was expressed in memory-related brain structures. Functional magnetic resonance imaging detected KIBRA allele-dependent differences in hippocampal activations during memory retrieval. Evidence from these experiments suggests a role for KIBRA in human memory.

AB - Human memory is a polygenic trait. We performed a genome-wide screen to identify memory-related gene variants. A genomic locus encoding the brain protein KIBRA was significantly associated with memory performance in three independent, cognitively normal cohorts from Switzerland and the United States. Gene expression studies showed that KIBRA was expressed in memory-related brain structures. Functional magnetic resonance imaging detected KIBRA allele-dependent differences in hippocampal activations during memory retrieval. Evidence from these experiments suggests a role for KIBRA in human memory.

UR - http://www.scopus.com/inward/record.url?scp=33750334020&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=33750334020&partnerID=8YFLogxK

U2 - 10.1126/science.1129837

DO - 10.1126/science.1129837

M3 - Article

C2 - 17053149

AN - SCOPUS:33750334020

SN - 0036-8075

VL - 314

SP - 475

EP - 478

JO - Science

JF - Science

IS - 5798

ER -

Common Kibra alleles are associated with human memory performance

Abstract

ASJC Scopus subject areas

Access to Document

Other files and links

Fingerprint

Cite this