Common Kibra alleles are associated with human memory performance

Andreas Papassotiropoulos, Dietrich A. Stephan, Matthew J. Huentelman, Frederic J. Hoerndli, David W. Craig, John V. Pearson, Kim Dung Huynh, Fabienne Brunner, Jason Corneveaux, David Osborne, M. Axel Wollmer, Amanda Aerni, Daniel Coluccia, Jürgen Hänggi, Christian R.A. Mondadori, Andreas Buchmann, Eric M. Reiman, Richard J. Caselli, Katharina Henke, Dominique J.F. De Quervain

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304 Scopus citations

Abstract

Human memory is a polygenic trait. We performed a genome-wide screen to identify memory-related gene variants. A genomic locus encoding the brain protein KIBRA was significantly associated with memory performance in three independent, cognitively normal cohorts from Switzerland and the United States. Gene expression studies showed that KIBRA was expressed in memory-related brain structures. Functional magnetic resonance imaging detected KIBRA allele-dependent differences in hippocampal activations during memory retrieval. Evidence from these experiments suggests a role for KIBRA in human memory.

Original languageEnglish (US)
Pages (from-to)475-478
Number of pages4
JournalScience
Volume314
Issue number5798
DOIs
StatePublished - Oct 20 2006

ASJC Scopus subject areas

  • General

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    Papassotiropoulos, A., Stephan, D. A., Huentelman, M. J., Hoerndli, F. J., Craig, D. W., Pearson, J. V., Huynh, K. D., Brunner, F., Corneveaux, J., Osborne, D., Wollmer, M. A., Aerni, A., Coluccia, D., Hänggi, J., Mondadori, C. R. A., Buchmann, A., Reiman, E. M., Caselli, R. J., Henke, K., & De Quervain, D. J. F. (2006). Common Kibra alleles are associated with human memory performance. Science, 314(5798), 475-478. https://doi.org/10.1126/science.1129837