Combined plasma exchange and platelet transfusion in immune-mediated thrombocytopenic emergencies

Laura Finn, Han Tun

Research output: Contribution to journalArticle

3 Scopus citations

Abstract

Refractory immune-mediated thrombocytopenia (ITP) can be very difficult to manage, especially if associated with a hemorrhagic or surgical emergency. We report two cases of refractory ITP that were unresponsive to routine therapeutic interventions and frequent platelet transfusions. A combination of plasma exchange and platelet transfusion successfully raised the platelet count to a level that permitted life-saving surgical interventions. Plasma exchange in these two cases likely reduced platelet antibodies significantly, decreasing platelet destruction. We propose that a trial of combination plasma exchange and platelet transfusion can be attempted in emergent thrombocytopenic situations with an underlying immune mechanism.

Original languageEnglish (US)
Pages (from-to)661-664
Number of pages4
JournalTransfusion and Apheresis Science
Volume49
Issue number3
DOIs
StatePublished - Dec 1 2013

Keywords

  • Immune mediated thrombocytopenia
  • Plasma exchange

ASJC Scopus subject areas

  • Hematology

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