Colonic tone and motility in patients with irritable bowel syndrome

M. J. Vassallo, Michael Camilleri, S. F. Phillips, C. J. Steadman, N. J. Talley, R. B. Hanson, A. C. Haddad

Research output: Contribution to journalArticle

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Abstract

In this study, our aim was to test the hypothesis that colonic tone is abnormal in patients with irritable bowel syndrome (IBS). We studied eight patients with IBS and eight age-matched asymptomatic control subjects, in whom tone and motility were measured by an electronic barostat and by pneumohydraulic perfusion manometry, respectively. Tone and motility were recorded from the descending colon for a 14-hour period-3 hours awake, 7 hours asleep, 2 hours fasting after awakening, and 2 hours postprandially. In patients with IBS and in healthy subjects, colonic tone decreased by up to 50% during sleep and increased promptly on awakening. Fasting colonic tone (as quantified by the volume in the barostat balloon) in the awake state was not significantly higher in patients with IBS than it was in healthy subjects (125 ± 13 versus 152 ± 15 ml; P = 0.19). Tone increased postprandially in both study groups, and the increase was greater in healthy subjects than it was in patients with IBS (P

Original languageEnglish (US)
Pages (from-to)725-731
Number of pages7
JournalMayo Clinic Proceedings
Volume67
Issue number8
StatePublished - 1992

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Irritable Bowel Syndrome
Healthy Volunteers
Fasting
Descending Colon
Manometry
Sleep
Perfusion

ASJC Scopus subject areas

  • Medicine(all)

Cite this

Vassallo, M. J., Camilleri, M., Phillips, S. F., Steadman, C. J., Talley, N. J., Hanson, R. B., & Haddad, A. C. (1992). Colonic tone and motility in patients with irritable bowel syndrome. Mayo Clinic Proceedings, 67(8), 725-731.

Colonic tone and motility in patients with irritable bowel syndrome. / Vassallo, M. J.; Camilleri, Michael; Phillips, S. F.; Steadman, C. J.; Talley, N. J.; Hanson, R. B.; Haddad, A. C.

In: Mayo Clinic Proceedings, Vol. 67, No. 8, 1992, p. 725-731.

Research output: Contribution to journalArticle

Vassallo, MJ, Camilleri, M, Phillips, SF, Steadman, CJ, Talley, NJ, Hanson, RB & Haddad, AC 1992, 'Colonic tone and motility in patients with irritable bowel syndrome', Mayo Clinic Proceedings, vol. 67, no. 8, pp. 725-731.
Vassallo MJ, Camilleri M, Phillips SF, Steadman CJ, Talley NJ, Hanson RB et al. Colonic tone and motility in patients with irritable bowel syndrome. Mayo Clinic Proceedings. 1992;67(8):725-731.
Vassallo, M. J. ; Camilleri, Michael ; Phillips, S. F. ; Steadman, C. J. ; Talley, N. J. ; Hanson, R. B. ; Haddad, A. C. / Colonic tone and motility in patients with irritable bowel syndrome. In: Mayo Clinic Proceedings. 1992 ; Vol. 67, No. 8. pp. 725-731.
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