Cognitive function testing in adult brain tumor trials

Lessons from a comprehensive review

Chip Caine, Minesh P. Mehta, Nadia N Laack, Vinai Gondi

Research output: Contribution to journalArticle

9 Citations (Scopus)

Abstract

Neurocognitive function (NCF) impairment is an important component of primary and metastatic brain tumors and their therapeutic interventions. As a result, modern clinical trials of cranial irradiation for adult cancer patients have incorporated NCF testing as a primary or secondary end point. In doing so, these clinical trials have provided a novel insight into our understanding of the NCF effects of cranial irradiation and brain tumor progression. In this article, we review these clinical trials both in terms of the trial findings and in terms of the types of NCF tests used in these trials. We also provide an introduction to the strengths and limitations of these NCF tests, as well as expert commentary on the current status and future directions of NCF testing in brain tumor trials.

Original languageEnglish (US)
Pages (from-to)655-667
Number of pages13
JournalExpert Review of Anticancer Therapy
Volume12
Issue number5
DOIs
StatePublished - May 2012

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Brain Neoplasms
Cognition
Cranial Irradiation
Clinical Trials
Neoplasms
Therapeutics
Direction compound

Keywords

  • brain tumors
  • cranial irradiation
  • Hopkins Verbal Learning Test
  • Mini-Mental Status Exam
  • neurocognitive function
  • Stroop test
  • Trail Making Tests
  • whole-brain radiotherapy

ASJC Scopus subject areas

  • Pharmacology (medical)
  • Oncology

Cite this

Cognitive function testing in adult brain tumor trials : Lessons from a comprehensive review. / Caine, Chip; Mehta, Minesh P.; Laack, Nadia N; Gondi, Vinai.

In: Expert Review of Anticancer Therapy, Vol. 12, No. 5, 05.2012, p. 655-667.

Research output: Contribution to journalArticle

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