TY - JOUR
T1 - Cogan's Syndrome
T2 - An Audiovestibular, Ocular, and Systemic Autoimmune Disease
AU - Mazlumzadeh, Mehrdad
AU - Matteson, Eric L.
N1 - Funding Information:
Mehrdad Mazlumzadeh has received grants from the Mayo Foundation. Eric L. Matteson is an Investigator for Amgen, Biogen-IDEC, Centocor, Genentech, Hoffmann-LaRoche, Human Genome Sciences, and Wyeth. Dr. Matteson has received grant support from Amgen, Aventis, Bristol-Myers-Squibb, Centocor/Johnson & Johnson, Genentech, Mayo Foundation, Novartis, and the National Institutes of Health. Dr. Matteson has served as consultant to and/or on the scientific advisory board of Amgen, Biogen-IDEC, Burroughs-Wellcome, Centocor, Novartis, Regeneron, Takeda, and the Vasculitis Foundation.
PY - 2007/11
Y1 - 2007/11
N2 - Cogan's syndrome is an immune-mediated systemic disorder characterized by ocular and audiovestibular inflammation. Although interstitial keratitis in the absence of an infectious cause is the classic form of eye involvement, other nonspecific inflammatory eye diseases can also occur, often making prompt diagnosis of the underlying disease challenging. The audiovestibular disease is difficult to treat and can lead to profound hearing loss. A poor outcome, especially complete hearing loss, can sometimes be prevented through a timely recognition and initiation of glucocorticoid therapy at the onset of the disease.
AB - Cogan's syndrome is an immune-mediated systemic disorder characterized by ocular and audiovestibular inflammation. Although interstitial keratitis in the absence of an infectious cause is the classic form of eye involvement, other nonspecific inflammatory eye diseases can also occur, often making prompt diagnosis of the underlying disease challenging. The audiovestibular disease is difficult to treat and can lead to profound hearing loss. A poor outcome, especially complete hearing loss, can sometimes be prevented through a timely recognition and initiation of glucocorticoid therapy at the onset of the disease.
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U2 - 10.1016/j.rdc.2007.07.015
DO - 10.1016/j.rdc.2007.07.015
M3 - Review article
C2 - 18037121
AN - SCOPUS:36248945006
SN - 0889-857X
VL - 33
SP - 855
EP - 874
JO - Rheumatic Disease Clinics of North America
JF - Rheumatic Disease Clinics of North America
IS - 4
ER -