Coccidioidomycosis in liver transplant recipients relocating to an endemic area

Janis E. Blair, David D. Douglas

Research output: Contribution to journalArticle

22 Citations (Scopus)

Abstract

Coccidioidomycosis is an endemic fungal infection of the desert southwestern United States. This infection occurs at a rate of 1% to 8% in solid organ transplant recipients residing in the endemic area, and it has a high rate of disseminated infection and mortality. The risk of infection among transplant recipients from nonendemic areas visiting or moving to an endemic region is not known. We reviewed the clinical course of 41 liver transplant recipients who originally resided in and underwent liver transplantation in an area of low coccidioidal endemicity and who later relocated their follow-up care to our program, which is located in an endemic area. No patients received antifungal prophylaxis to prevent primary coccidioidomycosis. Among 37 patients with at least 1 year of follow-up care, the incidence of new coccidioidal infection was 2.7%. Coccidioidomycosis was identified in one patient and was manifested by fatigue, anemia, and pulmonary nodules. This patient survived with oral antifungal therapy. Coccidioidomycosis was not a frequent event in liver transplant recipients from areas of low endemicity who relocated to our highly endemic area.

Original languageEnglish (US)
Pages (from-to)1981-1985
Number of pages5
JournalDigestive Diseases and Sciences
Volume49
Issue number11-12
DOIs
StatePublished - Nov 2004

Fingerprint

Coccidioidomycosis
Aftercare
Liver
Infection
Southwestern United States
Mycoses
Liver Transplantation
Fatigue
Anemia
Transplants
Lung
Mortality
Transplant Recipients
Incidence

Keywords

  • Antifungal prophylaxis
  • Coccidioidal infections
  • Immunosuppression
  • Liver transplantation

ASJC Scopus subject areas

  • Gastroenterology

Cite this

Coccidioidomycosis in liver transplant recipients relocating to an endemic area. / Blair, Janis E.; Douglas, David D.

In: Digestive Diseases and Sciences, Vol. 49, No. 11-12, 11.2004, p. 1981-1985.

Research output: Contribution to journalArticle

Blair, Janis E. ; Douglas, David D. / Coccidioidomycosis in liver transplant recipients relocating to an endemic area. In: Digestive Diseases and Sciences. 2004 ; Vol. 49, No. 11-12. pp. 1981-1985.
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