Co-release and interaction of two inhibitory co-transmitters in rat sacral dorsal commissural neurons

LongJun Wu, Yong Li, Tian Le Xu

Research output: Contribution to journalArticle

25 Citations (Scopus)

Abstract

Conventional whole-cell recording configuration was used to characterize the interaction between two inhibitory neurotansmitters, GABA and glycine, in synaptic bouton preparation obtained from rat sacral dorsal commissural nucleus (SDCN). The co-release of GABA and glycine as well as the interaction between their corresponding receptors was demonstrated. Furthermore, taking advantage of pure glycinergic terminal preparation, the possible interaction between GABA and glycine at synaptic level was studied. The results revealed a novel cross-modulation between the two inhibitory cotransmitters systems. This interaction may contribute to sensory processing such as nociception in the mammalian deep dorsal horn under physiological and/or pathological conditions.

Original languageEnglish (US)
Pages (from-to)977-981
Number of pages5
JournalNeuroReport
Volume13
Issue number7
DOIs
StatePublished - May 24 2002
Externally publishedYes

Fingerprint

Glycine
gamma-Aminobutyric Acid
Neurons
Nociception
Presynaptic Terminals
Patch-Clamp Techniques
Spinal Cord Dorsal Horn

Keywords

  • Co-release
  • GABA
  • Glycine
  • Sacral dorsal commissural nucleus

ASJC Scopus subject areas

  • Neuroscience(all)

Cite this

Co-release and interaction of two inhibitory co-transmitters in rat sacral dorsal commissural neurons. / Wu, LongJun; Li, Yong; Xu, Tian Le.

In: NeuroReport, Vol. 13, No. 7, 24.05.2002, p. 977-981.

Research output: Contribution to journalArticle

@article{8450efaae2bf459d8517c24e57fc6c7d,
title = "Co-release and interaction of two inhibitory co-transmitters in rat sacral dorsal commissural neurons",
abstract = "Conventional whole-cell recording configuration was used to characterize the interaction between two inhibitory neurotansmitters, GABA and glycine, in synaptic bouton preparation obtained from rat sacral dorsal commissural nucleus (SDCN). The co-release of GABA and glycine as well as the interaction between their corresponding receptors was demonstrated. Furthermore, taking advantage of pure glycinergic terminal preparation, the possible interaction between GABA and glycine at synaptic level was studied. The results revealed a novel cross-modulation between the two inhibitory cotransmitters systems. This interaction may contribute to sensory processing such as nociception in the mammalian deep dorsal horn under physiological and/or pathological conditions.",
keywords = "Co-release, GABA, Glycine, Sacral dorsal commissural nucleus",
author = "LongJun Wu and Yong Li and Xu, {Tian Le}",
year = "2002",
month = "5",
day = "24",
doi = "10.1097/00001756-200205240-00016",
language = "English (US)",
volume = "13",
pages = "977--981",
journal = "NeuroReport",
issn = "0959-4965",
publisher = "Lippincott Williams and Wilkins",
number = "7",

}

TY - JOUR

T1 - Co-release and interaction of two inhibitory co-transmitters in rat sacral dorsal commissural neurons

AU - Wu, LongJun

AU - Li, Yong

AU - Xu, Tian Le

PY - 2002/5/24

Y1 - 2002/5/24

N2 - Conventional whole-cell recording configuration was used to characterize the interaction between two inhibitory neurotansmitters, GABA and glycine, in synaptic bouton preparation obtained from rat sacral dorsal commissural nucleus (SDCN). The co-release of GABA and glycine as well as the interaction between their corresponding receptors was demonstrated. Furthermore, taking advantage of pure glycinergic terminal preparation, the possible interaction between GABA and glycine at synaptic level was studied. The results revealed a novel cross-modulation between the two inhibitory cotransmitters systems. This interaction may contribute to sensory processing such as nociception in the mammalian deep dorsal horn under physiological and/or pathological conditions.

AB - Conventional whole-cell recording configuration was used to characterize the interaction between two inhibitory neurotansmitters, GABA and glycine, in synaptic bouton preparation obtained from rat sacral dorsal commissural nucleus (SDCN). The co-release of GABA and glycine as well as the interaction between their corresponding receptors was demonstrated. Furthermore, taking advantage of pure glycinergic terminal preparation, the possible interaction between GABA and glycine at synaptic level was studied. The results revealed a novel cross-modulation between the two inhibitory cotransmitters systems. This interaction may contribute to sensory processing such as nociception in the mammalian deep dorsal horn under physiological and/or pathological conditions.

KW - Co-release

KW - GABA

KW - Glycine

KW - Sacral dorsal commissural nucleus

UR - http://www.scopus.com/inward/record.url?scp=0037165930&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=0037165930&partnerID=8YFLogxK

U2 - 10.1097/00001756-200205240-00016

DO - 10.1097/00001756-200205240-00016

M3 - Article

C2 - 12004203

AN - SCOPUS:0037165930

VL - 13

SP - 977

EP - 981

JO - NeuroReport

JF - NeuroReport

SN - 0959-4965

IS - 7

ER -