TY - JOUR
T1 - Co-ordination of mucosal b cell and cd8 t cell memory by tissue-resident cd4 helper t cells
AU - Son, Young Min
AU - Sun, Jie
N1 - Publisher Copyright:
© 2021 by the authors. Licensee MDPI, Basel, Switzerland.
PY - 2021/9
Y1 - 2021/9
N2 - Adaptive cellular immunity plays a major role in clearing microbial invasion of mucosal tissues in mammals. Following the clearance of primary pathogens, memory lymphocytes are established both systemically and locally at pathogen entry sites. Recently, resident memory CD8 T and B cells (TRM and BRM respectively), which are parked mainly in non-lymphoid mucosal tissues, were characterized and demonstrated to be essential for protection against secondary microbial invasion. Here we reviewed the current understanding of the cellular and molecular cues regulating CD8 TRM and BRM development, maintenance and function. We focused particularly on elucidating the role of a novel tissue-resident helper T (TRH ) cell population in assisting TRM and BRM responses in the respiratory mucosa following viral infection. Finally, we argue that the promotion of TRH responses by future mucosal vaccines would be key to the development of successful universal influenza or coronavirus vaccines, providing long-lasting immunity against a broad spectrum of viral strains.
AB - Adaptive cellular immunity plays a major role in clearing microbial invasion of mucosal tissues in mammals. Following the clearance of primary pathogens, memory lymphocytes are established both systemically and locally at pathogen entry sites. Recently, resident memory CD8 T and B cells (TRM and BRM respectively), which are parked mainly in non-lymphoid mucosal tissues, were characterized and demonstrated to be essential for protection against secondary microbial invasion. Here we reviewed the current understanding of the cellular and molecular cues regulating CD8 TRM and BRM development, maintenance and function. We focused particularly on elucidating the role of a novel tissue-resident helper T (TRH ) cell population in assisting TRM and BRM responses in the respiratory mucosa following viral infection. Finally, we argue that the promotion of TRH responses by future mucosal vaccines would be key to the development of successful universal influenza or coronavirus vaccines, providing long-lasting immunity against a broad spectrum of viral strains.
KW - Mucosal immunity
KW - Non-lymphoid tissues
KW - Tissue resident memory B
KW - Tissue resident memory T
UR - http://www.scopus.com/inward/record.url?scp=85115888343&partnerID=8YFLogxK
UR - http://www.scopus.com/inward/citedby.url?scp=85115888343&partnerID=8YFLogxK
U2 - 10.3390/cells10092355
DO - 10.3390/cells10092355
M3 - Review article
C2 - 34572004
AN - SCOPUS:85115888343
SN - 2073-4409
VL - 10
JO - Cells
JF - Cells
IS - 9
M1 - 2355
ER -