Clustering of hepatocellular carcinoma in Alaska Native families

Steven R. Alberts; Anne P. Lanier; Brian J. McMahon; Annette Harpster; Lisa R. Bulkow; William L. Heyward; Christine Murray; G. P. Vogler

doi:10.1002/gepi.1370080206

Clustering of hepatocellular carcinoma in Alaska Native families

Steven R. Alberts, Anne P. Lanier, Brian J. McMahon, Annette Harpster, Lisa R. Bulkow, William L. Heyward, Christine Murray, G. P. Vogler

Medical Oncology

Research output: Contribution to journal › Article › peer-review

27 Scopus citations

Abstract

Alaska Natives have a high incidence of hepatocellular carcinoma (HCC), with regional, ethnic, village, and familial clustering. During 1969–1988, 15 of the 45 incident cases of HCC in Alaska Natives occurred in 5 families. This report presents epidemiologic, virologic, and immunogenetic data on these 5 families. The results of hepatitis B virus (HBV) serologic testing indicates that HBV infection was an important factor in 4 of the 5 families. Human lymphocyte antigen (HLA) testing was performed in 3 families. The HLA results are reviewed in relationship to the familial clustering of HCC.

Original language	English (US)
Pages (from-to)	127-139
Number of pages	13
Journal	Genetic epidemiology
Volume	8
Issue number	2
DOIs	https://doi.org/10.1002/gepi.1370080206
State	Published - 1991

Keywords

Alaska Native
HLA
familial clustering
hepatitis B virus
hepatocellular carcinoma

ASJC Scopus subject areas

Epidemiology
Genetics(clinical)

Access to Document

10.1002/gepi.1370080206

Cite this

@article{dff0cf63499c43f08b8b62456d75b3fc,

title = "Clustering of hepatocellular carcinoma in Alaska Native families",

abstract = "Alaska Natives have a high incidence of hepatocellular carcinoma (HCC), with regional, ethnic, village, and familial clustering. During 1969–1988, 15 of the 45 incident cases of HCC in Alaska Natives occurred in 5 families. This report presents epidemiologic, virologic, and immunogenetic data on these 5 families. The results of hepatitis B virus (HBV) serologic testing indicates that HBV infection was an important factor in 4 of the 5 families. Human lymphocyte antigen (HLA) testing was performed in 3 families. The HLA results are reviewed in relationship to the familial clustering of HCC.",

keywords = "Alaska Native, HLA, familial clustering, hepatitis B virus, hepatocellular carcinoma",

author = "Alberts, {Steven R.} and Lanier, {Anne P.} and McMahon, {Brian J.} and Annette Harpster and Bulkow, {Lisa R.} and Heyward, {William L.} and Christine Murray and Vogler, {G. P.}",

year = "1991",

doi = "10.1002/gepi.1370080206",

language = "English (US)",

volume = "8",

pages = "127--139",

journal = "Genetic epidemiology",

issn = "0741-0395",

publisher = "Wiley-Liss Inc.",

number = "2",

}

TY - JOUR

T1 - Clustering of hepatocellular carcinoma in Alaska Native families

AU - Alberts, Steven R.

AU - Lanier, Anne P.

AU - McMahon, Brian J.

AU - Harpster, Annette

AU - Bulkow, Lisa R.

AU - Heyward, William L.

AU - Murray, Christine

AU - Vogler, G. P.

PY - 1991

Y1 - 1991

N2 - Alaska Natives have a high incidence of hepatocellular carcinoma (HCC), with regional, ethnic, village, and familial clustering. During 1969–1988, 15 of the 45 incident cases of HCC in Alaska Natives occurred in 5 families. This report presents epidemiologic, virologic, and immunogenetic data on these 5 families. The results of hepatitis B virus (HBV) serologic testing indicates that HBV infection was an important factor in 4 of the 5 families. Human lymphocyte antigen (HLA) testing was performed in 3 families. The HLA results are reviewed in relationship to the familial clustering of HCC.

AB - Alaska Natives have a high incidence of hepatocellular carcinoma (HCC), with regional, ethnic, village, and familial clustering. During 1969–1988, 15 of the 45 incident cases of HCC in Alaska Natives occurred in 5 families. This report presents epidemiologic, virologic, and immunogenetic data on these 5 families. The results of hepatitis B virus (HBV) serologic testing indicates that HBV infection was an important factor in 4 of the 5 families. Human lymphocyte antigen (HLA) testing was performed in 3 families. The HLA results are reviewed in relationship to the familial clustering of HCC.

KW - Alaska Native

KW - HLA

KW - familial clustering

KW - hepatitis B virus

KW - hepatocellular carcinoma

UR - http://www.scopus.com/inward/record.url?scp=0025772734&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=0025772734&partnerID=8YFLogxK

U2 - 10.1002/gepi.1370080206

DO - 10.1002/gepi.1370080206

M3 - Article

C2 - 1655562

AN - SCOPUS:0025772734

SN - 0741-0395

VL - 8

SP - 127

EP - 139

JO - Genetic epidemiology

JF - Genetic epidemiology

IS - 2

ER -

Clustering of hepatocellular carcinoma in Alaska Native families

Abstract

Keywords

ASJC Scopus subject areas

Access to Document

Other files and links

Fingerprint

Cite this