Clustering of hepatocellular carcinoma in Alaska Native families

Steven R. Alberts, Anne P. Lanier, Brian J. McMahon, Annette Harpster, Lisa R. Bulkow, William L. Heyward, Christine Murray, G. P. Vogler

Research output: Contribution to journalArticlepeer-review

27 Scopus citations

Abstract

Alaska Natives have a high incidence of hepatocellular carcinoma (HCC), with regional, ethnic, village, and familial clustering. During 1969–1988, 15 of the 45 incident cases of HCC in Alaska Natives occurred in 5 families. This report presents epidemiologic, virologic, and immunogenetic data on these 5 families. The results of hepatitis B virus (HBV) serologic testing indicates that HBV infection was an important factor in 4 of the 5 families. Human lymphocyte antigen (HLA) testing was performed in 3 families. The HLA results are reviewed in relationship to the familial clustering of HCC.

Original languageEnglish (US)
Pages (from-to)127-139
Number of pages13
JournalGenetic epidemiology
Volume8
Issue number2
DOIs
StatePublished - 1991

Keywords

  • Alaska Native
  • HLA
  • familial clustering
  • hepatitis B virus
  • hepatocellular carcinoma

ASJC Scopus subject areas

  • Epidemiology
  • Genetics(clinical)

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