Clonidine and naltrexone in the outpatient treatment of heroin withdrawal

Herbert D. Kleber, Mark Topazian, Joseph Gaspari, Charles E. Riordan, Thomas Kosten

Research output: Contribution to journalArticle

79 Citations (Scopus)

Abstract

Abstract Clonidine hydrochloride (an alpha-2 adrenergic agonist) and naltrexone hydrochloride (an opioid antagonist), given in combination, provided a safe and effective treatment of abrupt opioid withdrawal over 5 days in an outpatient/day setting. Before starting the clonidine, a naloxone challenge test was used to verify and quantify opioid dependence, and the naloxone challenge test score was then used to determine initial medication doses. Initial naloxone challenge test scores predicted subsequent patient discomfort during the 5-day clonidine-naltrexone protocol. Twelve of 14 (86% heroin users successfully withdrew from opioids and simultaneously initiated naltrexone maintenance.

Original languageEnglish (US)
Pages (from-to)1-17
Number of pages17
JournalAmerican Journal of Drug and Alcohol Abuse
Volume13
Issue number1-2
DOIs
StatePublished - Jan 1 1987
Externally publishedYes

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Naltrexone
Heroin
Clonidine
Naloxone
Opioid Analgesics
Outpatients
Adrenergic alpha-2 Receptor Agonists
Narcotic Antagonists
Therapeutics

ASJC Scopus subject areas

  • Medicine (miscellaneous)
  • Clinical Psychology
  • Psychiatry and Mental health

Cite this

Clonidine and naltrexone in the outpatient treatment of heroin withdrawal. / Kleber, Herbert D.; Topazian, Mark; Gaspari, Joseph; Riordan, Charles E.; Kosten, Thomas.

In: American Journal of Drug and Alcohol Abuse, Vol. 13, No. 1-2, 01.01.1987, p. 1-17.

Research output: Contribution to journalArticle

Kleber, Herbert D. ; Topazian, Mark ; Gaspari, Joseph ; Riordan, Charles E. ; Kosten, Thomas. / Clonidine and naltrexone in the outpatient treatment of heroin withdrawal. In: American Journal of Drug and Alcohol Abuse. 1987 ; Vol. 13, No. 1-2. pp. 1-17.
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