Clonal relationships between malignant lymphomas and histiocytic/dendritic cell tumors

Andrew L. Feldman

doi:10.1016/j.path.2013.08.003

Clonal relationships between malignant lymphomas and histiocytic/dendritic cell tumors

Andrew L. Feldman

Laboratory Medicine and Pathology

Research output: Contribution to journal › Review article › peer-review

3 Scopus citations

Abstract

Tumors of histiocytic or dendritic cell origin appear to occur with increased frequency in patients with lymphoma. Recent molecular data have demonstrated clonal relationships between the lymphoma and the histiocytic/dendritic cell tumor in some of these cases. Clinical, pathologic, and experimental data suggest that this phenomenon probably represents transdifferentiation of the lymphoma clone to a histiocytic/dendritic cell lineage in most cases. Awareness of this entity is necessary to prompt comparative molecular studies in appropriate cases.

Original language	English (US)
Pages (from-to)	619-629
Number of pages	11
Journal	Surgical Pathology Clinics
Volume	6
Issue number	4
DOIs	https://doi.org/10.1016/j.path.2013.08.003
State	Published - Dec 2013

Keywords

Clonality
Dendritic cell tumor
Histiocytic sarcoma
Langerhans cell histiocytosis
Lineage plasticity
Transdifferentiation
Transformation

ASJC Scopus subject areas

Surgery
Pathology and Forensic Medicine

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10.1016/j.path.2013.08.003

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title = "Clonal relationships between malignant lymphomas and histiocytic/dendritic cell tumors",

abstract = "Tumors of histiocytic or dendritic cell origin appear to occur with increased frequency in patients with lymphoma. Recent molecular data have demonstrated clonal relationships between the lymphoma and the histiocytic/dendritic cell tumor in some of these cases. Clinical, pathologic, and experimental data suggest that this phenomenon probably represents transdifferentiation of the lymphoma clone to a histiocytic/dendritic cell lineage in most cases. Awareness of this entity is necessary to prompt comparative molecular studies in appropriate cases.",

keywords = "Clonality, Dendritic cell tumor, Histiocytic sarcoma, Langerhans cell histiocytosis, Lineage plasticity, Transdifferentiation, Transformation",

author = "Feldman, {Andrew L.}",

year = "2013",

month = dec,

doi = "10.1016/j.path.2013.08.003",

language = "English (US)",

volume = "6",

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journal = "Surgical Pathology Clinics",

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publisher = "W.B. Saunders Ltd",

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T1 - Clonal relationships between malignant lymphomas and histiocytic/dendritic cell tumors

AU - Feldman, Andrew L.

PY - 2013/12

Y1 - 2013/12

N2 - Tumors of histiocytic or dendritic cell origin appear to occur with increased frequency in patients with lymphoma. Recent molecular data have demonstrated clonal relationships between the lymphoma and the histiocytic/dendritic cell tumor in some of these cases. Clinical, pathologic, and experimental data suggest that this phenomenon probably represents transdifferentiation of the lymphoma clone to a histiocytic/dendritic cell lineage in most cases. Awareness of this entity is necessary to prompt comparative molecular studies in appropriate cases.

AB - Tumors of histiocytic or dendritic cell origin appear to occur with increased frequency in patients with lymphoma. Recent molecular data have demonstrated clonal relationships between the lymphoma and the histiocytic/dendritic cell tumor in some of these cases. Clinical, pathologic, and experimental data suggest that this phenomenon probably represents transdifferentiation of the lymphoma clone to a histiocytic/dendritic cell lineage in most cases. Awareness of this entity is necessary to prompt comparative molecular studies in appropriate cases.

KW - Clonality

KW - Dendritic cell tumor

KW - Histiocytic sarcoma

KW - Langerhans cell histiocytosis

KW - Lineage plasticity

KW - Transdifferentiation

KW - Transformation

UR - http://www.scopus.com/inward/record.url?scp=84887620587&partnerID=8YFLogxK

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U2 - 10.1016/j.path.2013.08.003

DO - 10.1016/j.path.2013.08.003

M3 - Review article

AN - SCOPUS:84887620587

SN - 1875-9181

VL - 6

SP - 619

EP - 629

JO - Surgical Pathology Clinics

JF - Surgical Pathology Clinics

IS - 4

ER -

Clonal relationships between malignant lymphomas and histiocytic/dendritic cell tumors

Abstract

Keywords

ASJC Scopus subject areas

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