Abstract
Using a panel of DNA probes for hypervariable DNA regions we screened 52 gastrointestinal carcinomas for clonal allele losses on chromosomes 1, 5, 7, 12, 16 and 17. A total of 24/35 informative cases of colorectal cancers showed loss of constitutional heterozygosity at a locus on chromosome 17p, while 9/31 cases informative for a locus on 5q showed allele loss. Loss of sequences at 5q was linked to allele loss at 17p with a single exception. In gastric cancers loss of heterozygosity most frequently occurred at lq (5/10 tumours) and at 12q (6/lltumours). Gastrointestinal tumours show consistent chromosomal losses and the loci involved are different in gastric and colorectal cancers.
Original language | English (US) |
---|---|
Pages (from-to) | 750-754 |
Number of pages | 5 |
Journal | British journal of cancer |
Volume | 59 |
Issue number | 5 |
DOIs | |
State | Published - May 1989 |
ASJC Scopus subject areas
- Oncology
- Cancer Research