Clonal allele loss in gastrointestinal cancers

M. F. Fey, C. Hesketh, J. S. Wainscoat, S. Gendler, S. L. Thein

Research output: Contribution to journalArticle

56 Scopus citations

Abstract

Using a panel of DNA probes for hypervariable DNA regions we screened 52 gastrointestinal carcinomas for clonal allele losses on chromosomes 1, 5, 7, 12, 16 and 17. A total of 24/35 informative cases of colorectal cancers showed loss of constitutional heterozygosity at a locus on chromosome 17p, while 9/31 cases informative for a locus on 5q showed allele loss. Loss of sequences at 5q was linked to allele loss at 17p with a single exception. In gastric cancers loss of heterozygosity most frequently occurred at lq (5/10 tumours) and at 12q (6/lltumours). Gastrointestinal tumours show consistent chromosomal losses and the loci involved are different in gastric and colorectal cancers.

Original languageEnglish (US)
Pages (from-to)750-754
Number of pages5
JournalBritish journal of cancer
Volume59
Issue number5
DOIs
StatePublished - May 1989

ASJC Scopus subject areas

  • Oncology
  • Cancer Research

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    Fey, M. F., Hesketh, C., Wainscoat, J. S., Gendler, S., & Thein, S. L. (1989). Clonal allele loss in gastrointestinal cancers. British journal of cancer, 59(5), 750-754. https://doi.org/10.1038/bjc.1989.157