Clinicopathological and 123I-FP-CIT SPECT correlations in patients with dementia

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5 Scopus citations

Abstract

The relationship between clinicopathologic diagnosis and 123I-FP-CIT SPECT in 18 patients with dementia (12 with Lewy body disease) from one center in the United States was assessed. The sensitivity and specificity of abnormal 123I-FP-CIT SPECT with reduced striatal uptake on visual inspection for predicting Lewy body disease were 91.7% and 83.3%, respectively. The mean calculated putamen to occipital ratio (mPOR) based on regions of interest was significantly reduced in Lewy body disease compared to non-Lewy body disease cases (P = 0.002). In this study, abnormal 123I-FP-CIT SPECT was strongly associated with underlying Lewy body disease pathology, supporting the utility of 123I-FP-CIT SPECT in the clinical diagnosis of dementia with Lewy bodies.

Original languageEnglish (US)
Pages (from-to)376-381
Number of pages6
JournalAnnals of Clinical and Translational Neurology
Volume5
Issue number3
DOIs
StatePublished - Mar 2018

ASJC Scopus subject areas

  • Neuroscience(all)
  • Clinical Neurology

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