Clinicopathological and 123I-FP-CIT SPECT correlations in patients with dementia

Youngsin Jung; Lennon G. Jordan; Val J. Lowe; Kejal Kantarci; Joseph E. Parisi; Dennis W. Dickson; Melissa E. Murray; Ross R. Reichard; Tanis J. Ferman; David T. Jones; Jonathan Graff-Radford; Rodolfo Savica; Mary M. Machulda; Julie A. Fields; Laura A. Allen; Daniel A. Drubach; Erik K. St. Louis; Michael H. Silber; Clifford R. Jack; David S. Knopman; Ronald C. Petersen; Bradley F. Boeve

doi:10.1002/acn3.521

Clinicopathological and ¹²³I-FP-CIT SPECT correlations in patients with dementia

Youngsin Jung, Lennon G. Jordan, Val J. Lowe, Kejal Kantarci, Joseph E. Parisi, Dennis W. Dickson, Melissa E. Murray, Ross R. Reichard, Tanis J. Ferman, David T. Jones, Jonathan Graff-Radford, Rodolfo Savica, Mary M. Machulda, Julie A. Fields, Laura A. Allen, Daniel A. Drubach, Erik K. St. Louis, Michael H. Silber, Clifford R. Jack, David S. KnopmanRonald C. Petersen, Bradley F. Boeve

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5 Scopus citations

Abstract

The relationship between clinicopathologic diagnosis and ¹²³I-FP-CIT SPECT in 18 patients with dementia (12 with Lewy body disease) from one center in the United States was assessed. The sensitivity and specificity of abnormal ¹²³I-FP-CIT SPECT with reduced striatal uptake on visual inspection for predicting Lewy body disease were 91.7% and 83.3%, respectively. The mean calculated putamen to occipital ratio (mPOR) based on regions of interest was significantly reduced in Lewy body disease compared to non-Lewy body disease cases (P = 0.002). In this study, abnormal ¹²³I-FP-CIT SPECT was strongly associated with underlying Lewy body disease pathology, supporting the utility of ¹²³I-FP-CIT SPECT in the clinical diagnosis of dementia with Lewy bodies.

Original language	English (US)
Pages (from-to)	376-381
Number of pages	6
Journal	Annals of Clinical and Translational Neurology
Volume	5
Issue number	3
DOIs	https://doi.org/10.1002/acn3.521
State	Published - Mar 2018

ASJC Scopus subject areas

General Neuroscience
Clinical Neurology

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Jung, Y., Jordan, L. G., Lowe, V. J., Kantarci, K., Parisi, J. E., Dickson, D. W., Murray, M. E., Reichard, R. R., Ferman, T. J., Jones, D. T., Graff-Radford, J., Savica, R., Machulda, M. M., Fields, J. A., Allen, L. A., Drubach, D. A., St. Louis, E. K., Silber, M. H., Jack, C. R., ... Boeve, B. F. (2018). Clinicopathological and ¹²³I-FP-CIT SPECT correlations in patients with dementia. Annals of Clinical and Translational Neurology, 5(3), 376-381. https://doi.org/10.1002/acn3.521

Jung, Y, Jordan, LG, Lowe, VJ , Kantarci, K, Parisi, JE, Dickson, DW , Murray, ME, Reichard, RR, Ferman, TJ , Jones, DT , Graff-Radford, J , Savica, R , Machulda, MM , Fields, JA, Allen, LA, Drubach, DA , St. Louis, EK, Silber, MH, Jack, CR , Knopman, DS , Petersen, RC & Boeve, BF 2018, 'Clinicopathological and ¹²³I-FP-CIT SPECT correlations in patients with dementia', Annals of Clinical and Translational Neurology, vol. 5, no. 3, pp. 376-381. https://doi.org/10.1002/acn3.521

@article{374bd9451abe4e6ebbbd8f8ff92518ae,

title = "Clinicopathological and 123I-FP-CIT SPECT correlations in patients with dementia",

abstract = "The relationship between clinicopathologic diagnosis and 123I-FP-CIT SPECT in 18 patients with dementia (12 with Lewy body disease) from one center in the United States was assessed. The sensitivity and specificity of abnormal 123I-FP-CIT SPECT with reduced striatal uptake on visual inspection for predicting Lewy body disease were 91.7% and 83.3%, respectively. The mean calculated putamen to occipital ratio (mPOR) based on regions of interest was significantly reduced in Lewy body disease compared to non-Lewy body disease cases (P = 0.002). In this study, abnormal 123I-FP-CIT SPECT was strongly associated with underlying Lewy body disease pathology, supporting the utility of 123I-FP-CIT SPECT in the clinical diagnosis of dementia with Lewy bodies.",

author = "Youngsin Jung and Jordan, {Lennon G.} and Lowe, {Val J.} and Kejal Kantarci and Parisi, {Joseph E.} and Dickson, {Dennis W.} and Murray, {Melissa E.} and Reichard, {Ross R.} and Ferman, {Tanis J.} and Jones, {David T.} and Jonathan Graff-Radford and Rodolfo Savica and Machulda, {Mary M.} and Fields, {Julie A.} and Allen, {Laura A.} and Drubach, {Daniel A.} and {St. Louis}, {Erik K.} and Silber, {Michael H.} and Jack, {Clifford R.} and Knopman, {David S.} and Petersen, {Ronald C.} and Boeve, {Bradley F.}",

note = "Publisher Copyright: {\textcopyright} 2018 The Authors. Annals of Clinical and Translational Neurology published by Wiley Periodicals, Inc on behalf of American Neurological Association.",

year = "2018",

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doi = "10.1002/acn3.521",

language = "English (US)",

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AU - Jung, Youngsin

AU - Jordan, Lennon G.

AU - Lowe, Val J.

AU - Kantarci, Kejal

AU - Parisi, Joseph E.

AU - Dickson, Dennis W.

AU - Murray, Melissa E.

AU - Reichard, Ross R.

AU - Ferman, Tanis J.

AU - Jones, David T.

AU - Graff-Radford, Jonathan

AU - Savica, Rodolfo

AU - Machulda, Mary M.

AU - Fields, Julie A.

AU - Allen, Laura A.

AU - Drubach, Daniel A.

AU - St. Louis, Erik K.

AU - Silber, Michael H.

AU - Jack, Clifford R.

AU - Knopman, David S.

AU - Petersen, Ronald C.

AU - Boeve, Bradley F.

PY - 2018/3

Y1 - 2018/3

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AB - The relationship between clinicopathologic diagnosis and 123I-FP-CIT SPECT in 18 patients with dementia (12 with Lewy body disease) from one center in the United States was assessed. The sensitivity and specificity of abnormal 123I-FP-CIT SPECT with reduced striatal uptake on visual inspection for predicting Lewy body disease were 91.7% and 83.3%, respectively. The mean calculated putamen to occipital ratio (mPOR) based on regions of interest was significantly reduced in Lewy body disease compared to non-Lewy body disease cases (P = 0.002). In this study, abnormal 123I-FP-CIT SPECT was strongly associated with underlying Lewy body disease pathology, supporting the utility of 123I-FP-CIT SPECT in the clinical diagnosis of dementia with Lewy bodies.

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Clinicopathological and ¹²³I-FP-CIT SPECT correlations in patients with dementia

Abstract

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