Clinicopathologic behavior of gastric adenocarcinoma in Hispanic patients: Analysis of a single institution's experience over 15 years

James C. Yao, Jennifer F. Tseng, Samidha Worah, Kenneth R. Hess, Paul F. Mansfield, Christopher H. Crane, Isac I. Schnirer, Satish Ready, Silvia S. Chiang, Azmeena Najam, Christina Yu, Geoffrey G. Giacco, Keping Xie, Tsung Teh Wu, Barry W. Feig, Peter W T Pisters, Jaffer A. Ajani

Research output: Contribution to journalArticle

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Abstract

Purpose: To determine the clinicopathologic behavior of gastric adenocarcinoma in Hispanics by comparing Hispanic and non-Hispanic patients treated at a single cancer center. Patients and Methods: Medical records of patients with invasive gastric cancer treated from 1985 to 1999 were reviewed. Diagnoses were pathologically confirmed. Differences in categorical variables were assessed using the χ2 test. Logistic regression was used for multivariate analyses. Median survival was estimated using the Kaplan-Meier method. Cox proportional hazards modeling was used to assess the impact of covariates. Results: Of 1,897 patients, 301 (15.9%) were Hispanic. Hispanics were significantly younger at diagnosis than non-Hispanic whites (53.1 ± 14.4 years v 59.4 ± 12.7 years, respectively; P < .005) or African Americans (57.6 ± 15.3 years, P < .005). Hispanics were less likely to have proximal gastric cancers compared with whites (38.9% v 59.5%, respectively; P < .005). Hispanics were more likely to have mucinous/signet-ring type histology (42.5%) than whites (27.4%) and African Americans (32.5%; P< .005). Hispanics were more likely to require total gastrectomy (51%) compared with whites (38%), African Americans (38%), and Asians (36%; P = .039). Among patients with metastases at diagnosis, Hispanics were less likely to have liver metastasis than whites (30% v44%, respectively; P = .009) but more likely to have peritoneal metastasis than whites and African Americans (54% v 41% and 47%, respectively; P = .002). In Cox analyses, Asian race, earlier stage, papillary/tubular histology, distal location, and younger age were favorable predictors of survival. Conclusion: Hispanic ethnicity does not impact survival in gastric adenocarcinoma. However, histology, metastasis pattern, tumor localization, and other clinical parameters differ sufficiently to warrant further investigation into the epidemiology, pathogenesis, and molecular biology of gastric cancer in this population.

Original languageEnglish (US)
Pages (from-to)3094-3103
Number of pages10
JournalJournal of Clinical Oncology
Volume23
Issue number13
DOIs
StatePublished - 2005
Externally publishedYes

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Hispanic Americans
Stomach
Adenocarcinoma
African Americans
Neoplasm Metastasis
Stomach Neoplasms
Histology
Survival
Gastrectomy
Medical Records
Molecular Biology
Neoplasms
Epidemiology
Multivariate Analysis
Logistic Models
Liver
Population

ASJC Scopus subject areas

  • Cancer Research
  • Oncology

Cite this

Clinicopathologic behavior of gastric adenocarcinoma in Hispanic patients : Analysis of a single institution's experience over 15 years. / Yao, James C.; Tseng, Jennifer F.; Worah, Samidha; Hess, Kenneth R.; Mansfield, Paul F.; Crane, Christopher H.; Schnirer, Isac I.; Ready, Satish; Chiang, Silvia S.; Najam, Azmeena; Yu, Christina; Giacco, Geoffrey G.; Xie, Keping; Wu, Tsung Teh; Feig, Barry W.; Pisters, Peter W T; Ajani, Jaffer A.

In: Journal of Clinical Oncology, Vol. 23, No. 13, 2005, p. 3094-3103.

Research output: Contribution to journalArticle

Yao, JC, Tseng, JF, Worah, S, Hess, KR, Mansfield, PF, Crane, CH, Schnirer, II, Ready, S, Chiang, SS, Najam, A, Yu, C, Giacco, GG, Xie, K, Wu, TT, Feig, BW, Pisters, PWT & Ajani, JA 2005, 'Clinicopathologic behavior of gastric adenocarcinoma in Hispanic patients: Analysis of a single institution's experience over 15 years', Journal of Clinical Oncology, vol. 23, no. 13, pp. 3094-3103. https://doi.org/10.1200/JCO.2005.08.987
Yao, James C. ; Tseng, Jennifer F. ; Worah, Samidha ; Hess, Kenneth R. ; Mansfield, Paul F. ; Crane, Christopher H. ; Schnirer, Isac I. ; Ready, Satish ; Chiang, Silvia S. ; Najam, Azmeena ; Yu, Christina ; Giacco, Geoffrey G. ; Xie, Keping ; Wu, Tsung Teh ; Feig, Barry W. ; Pisters, Peter W T ; Ajani, Jaffer A. / Clinicopathologic behavior of gastric adenocarcinoma in Hispanic patients : Analysis of a single institution's experience over 15 years. In: Journal of Clinical Oncology. 2005 ; Vol. 23, No. 13. pp. 3094-3103.
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title = "Clinicopathologic behavior of gastric adenocarcinoma in Hispanic patients: Analysis of a single institution's experience over 15 years",
abstract = "Purpose: To determine the clinicopathologic behavior of gastric adenocarcinoma in Hispanics by comparing Hispanic and non-Hispanic patients treated at a single cancer center. Patients and Methods: Medical records of patients with invasive gastric cancer treated from 1985 to 1999 were reviewed. Diagnoses were pathologically confirmed. Differences in categorical variables were assessed using the χ2 test. Logistic regression was used for multivariate analyses. Median survival was estimated using the Kaplan-Meier method. Cox proportional hazards modeling was used to assess the impact of covariates. Results: Of 1,897 patients, 301 (15.9{\%}) were Hispanic. Hispanics were significantly younger at diagnosis than non-Hispanic whites (53.1 ± 14.4 years v 59.4 ± 12.7 years, respectively; P < .005) or African Americans (57.6 ± 15.3 years, P < .005). Hispanics were less likely to have proximal gastric cancers compared with whites (38.9{\%} v 59.5{\%}, respectively; P < .005). Hispanics were more likely to have mucinous/signet-ring type histology (42.5{\%}) than whites (27.4{\%}) and African Americans (32.5{\%}; P< .005). Hispanics were more likely to require total gastrectomy (51{\%}) compared with whites (38{\%}), African Americans (38{\%}), and Asians (36{\%}; P = .039). Among patients with metastases at diagnosis, Hispanics were less likely to have liver metastasis than whites (30{\%} v44{\%}, respectively; P = .009) but more likely to have peritoneal metastasis than whites and African Americans (54{\%} v 41{\%} and 47{\%}, respectively; P = .002). In Cox analyses, Asian race, earlier stage, papillary/tubular histology, distal location, and younger age were favorable predictors of survival. Conclusion: Hispanic ethnicity does not impact survival in gastric adenocarcinoma. However, histology, metastasis pattern, tumor localization, and other clinical parameters differ sufficiently to warrant further investigation into the epidemiology, pathogenesis, and molecular biology of gastric cancer in this population.",
author = "Yao, {James C.} and Tseng, {Jennifer F.} and Samidha Worah and Hess, {Kenneth R.} and Mansfield, {Paul F.} and Crane, {Christopher H.} and Schnirer, {Isac I.} and Satish Ready and Chiang, {Silvia S.} and Azmeena Najam and Christina Yu and Giacco, {Geoffrey G.} and Keping Xie and Wu, {Tsung Teh} and Feig, {Barry W.} and Pisters, {Peter W T} and Ajani, {Jaffer A.}",
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T1 - Clinicopathologic behavior of gastric adenocarcinoma in Hispanic patients

T2 - Analysis of a single institution's experience over 15 years

AU - Yao, James C.

AU - Tseng, Jennifer F.

AU - Worah, Samidha

AU - Hess, Kenneth R.

AU - Mansfield, Paul F.

AU - Crane, Christopher H.

AU - Schnirer, Isac I.

AU - Ready, Satish

AU - Chiang, Silvia S.

AU - Najam, Azmeena

AU - Yu, Christina

AU - Giacco, Geoffrey G.

AU - Xie, Keping

AU - Wu, Tsung Teh

AU - Feig, Barry W.

AU - Pisters, Peter W T

AU - Ajani, Jaffer A.

PY - 2005

Y1 - 2005

N2 - Purpose: To determine the clinicopathologic behavior of gastric adenocarcinoma in Hispanics by comparing Hispanic and non-Hispanic patients treated at a single cancer center. Patients and Methods: Medical records of patients with invasive gastric cancer treated from 1985 to 1999 were reviewed. Diagnoses were pathologically confirmed. Differences in categorical variables were assessed using the χ2 test. Logistic regression was used for multivariate analyses. Median survival was estimated using the Kaplan-Meier method. Cox proportional hazards modeling was used to assess the impact of covariates. Results: Of 1,897 patients, 301 (15.9%) were Hispanic. Hispanics were significantly younger at diagnosis than non-Hispanic whites (53.1 ± 14.4 years v 59.4 ± 12.7 years, respectively; P < .005) or African Americans (57.6 ± 15.3 years, P < .005). Hispanics were less likely to have proximal gastric cancers compared with whites (38.9% v 59.5%, respectively; P < .005). Hispanics were more likely to have mucinous/signet-ring type histology (42.5%) than whites (27.4%) and African Americans (32.5%; P< .005). Hispanics were more likely to require total gastrectomy (51%) compared with whites (38%), African Americans (38%), and Asians (36%; P = .039). Among patients with metastases at diagnosis, Hispanics were less likely to have liver metastasis than whites (30% v44%, respectively; P = .009) but more likely to have peritoneal metastasis than whites and African Americans (54% v 41% and 47%, respectively; P = .002). In Cox analyses, Asian race, earlier stage, papillary/tubular histology, distal location, and younger age were favorable predictors of survival. Conclusion: Hispanic ethnicity does not impact survival in gastric adenocarcinoma. However, histology, metastasis pattern, tumor localization, and other clinical parameters differ sufficiently to warrant further investigation into the epidemiology, pathogenesis, and molecular biology of gastric cancer in this population.

AB - Purpose: To determine the clinicopathologic behavior of gastric adenocarcinoma in Hispanics by comparing Hispanic and non-Hispanic patients treated at a single cancer center. Patients and Methods: Medical records of patients with invasive gastric cancer treated from 1985 to 1999 were reviewed. Diagnoses were pathologically confirmed. Differences in categorical variables were assessed using the χ2 test. Logistic regression was used for multivariate analyses. Median survival was estimated using the Kaplan-Meier method. Cox proportional hazards modeling was used to assess the impact of covariates. Results: Of 1,897 patients, 301 (15.9%) were Hispanic. Hispanics were significantly younger at diagnosis than non-Hispanic whites (53.1 ± 14.4 years v 59.4 ± 12.7 years, respectively; P < .005) or African Americans (57.6 ± 15.3 years, P < .005). Hispanics were less likely to have proximal gastric cancers compared with whites (38.9% v 59.5%, respectively; P < .005). Hispanics were more likely to have mucinous/signet-ring type histology (42.5%) than whites (27.4%) and African Americans (32.5%; P< .005). Hispanics were more likely to require total gastrectomy (51%) compared with whites (38%), African Americans (38%), and Asians (36%; P = .039). Among patients with metastases at diagnosis, Hispanics were less likely to have liver metastasis than whites (30% v44%, respectively; P = .009) but more likely to have peritoneal metastasis than whites and African Americans (54% v 41% and 47%, respectively; P = .002). In Cox analyses, Asian race, earlier stage, papillary/tubular histology, distal location, and younger age were favorable predictors of survival. Conclusion: Hispanic ethnicity does not impact survival in gastric adenocarcinoma. However, histology, metastasis pattern, tumor localization, and other clinical parameters differ sufficiently to warrant further investigation into the epidemiology, pathogenesis, and molecular biology of gastric cancer in this population.

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