TY - JOUR
T1 - Clinical trials for inflammatory bowel disease
T2 - Global guidance during the covid-19 pandemic
AU - behalf of the International Organization for the Study of Inflammatory Bowel Diseases [IOIBD]
AU - Reinisch, Walter
AU - Danese, Silvio
AU - Peyrin-Biroulet, Laurent
AU - Loftus, Edward V.
N1 - Publisher Copyright:
© The Author(s) 2020. Published by Oxford University Press on behalf of European Crohn's and Colitis Organisation. All rights reserved.
PY - 2020/10/1
Y1 - 2020/10/1
N2 - The severe acute respiratory syndrome coronavirus 2 [SARS-CoV-2]-causing coronavirus disease [COVID]-19 pandemic poses major challenges for patients with inflammatory bowel disease [IBD] to be recruited and maintained in clinical trials. However, clinical trials offer patients who have failed multiple drugs access to study medications with alternative modes of action and the potential for relief from inflammation-mediated symptoms. Therefore, the continuation of clinical trials in IBD during the COVID-19 pandemic is important both for participants and for the community of IBD patients, due to the dire need for an expanded therapeutic armamentarium. As the safety of patients in clinical trials is the leading principle, we are providing ten specific rules to guide patients and principal investigators safely through the challenging time.
AB - The severe acute respiratory syndrome coronavirus 2 [SARS-CoV-2]-causing coronavirus disease [COVID]-19 pandemic poses major challenges for patients with inflammatory bowel disease [IBD] to be recruited and maintained in clinical trials. However, clinical trials offer patients who have failed multiple drugs access to study medications with alternative modes of action and the potential for relief from inflammation-mediated symptoms. Therefore, the continuation of clinical trials in IBD during the COVID-19 pandemic is important both for participants and for the community of IBD patients, due to the dire need for an expanded therapeutic armamentarium. As the safety of patients in clinical trials is the leading principle, we are providing ten specific rules to guide patients and principal investigators safely through the challenging time.
KW - COVID-19
KW - Clinical trials
KW - Crohn's disease
KW - Inflammatory bowel disease
KW - SARS-CoV2
KW - Ulcerative colitis
UR - http://www.scopus.com/inward/record.url?scp=85094220014&partnerID=8YFLogxK
UR - http://www.scopus.com/inward/citedby.url?scp=85094220014&partnerID=8YFLogxK
U2 - 10.1093/ecco-jcc/jjaa119
DO - 10.1093/ecco-jcc/jjaa119
M3 - Article
C2 - 32520311
AN - SCOPUS:85094220014
SN - 1873-9946
VL - 14
SP - S815-S819
JO - Journal of Crohn's and Colitis
JF - Journal of Crohn's and Colitis
ER -