Clinical presentation and outcomes of adults with bicuspid aortic valves: 2020 update

Li Tan Yang, Christophe Tribouilloy, Ahmad Masri, Jeroen J. Bax, Victoria Delgado, Evaldas Girdauskas, Arturo Evangelista, Thoralf M. Sundt, Lars G. Svensson, Maurice Enriquez-Sarano, Hector I. Michelena

Research output: Contribution to journalReview article

Abstract

The congenital bicuspid aortic valve (BAV) is a heterogeneous condition that is better understood considering 3 types of valvulo-aortopathy presentations: A typical-presentation valvulo-aortopathy, a complex-presentation valvulo-aortopathy and an uncomplicated/undiagnosed-presentation. The burden of BAV-related complications has been elucidated in patients with the typical-presentation valvulo-aortopathy and is discussed in this review. These patients enjoy an overall normal expected long-term survival as long as complications are identified and treated in a timely manner. This notion and the fact that the most dreaded complications (infective endocarditis and aortic dissection) are infrequent, represent important reassuring points for the BAV patient. Common complications such as valve dysfunction and aorta dilatation must be the subject of focused research in prevention and treatment. Conversely, BAV patients with complex-presentation valvulo-artopathy, as well as typical valvulo-aortopathy BAV patients who are older, with advanced valvular dysfunction, and possible late-referral to specialized care, may incur a survival penalty as compared to the general population. An evidence-based discussion of these concepts is provided in this review.

Original languageEnglish (US)
JournalProgress in Cardiovascular Diseases
DOIs
StateAccepted/In press - 2020

Keywords

  • Bicuspid aortic valve
  • Clinical history
  • Complication
  • Valve dysfunction

ASJC Scopus subject areas

  • Cardiology and Cardiovascular Medicine

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    Yang, L. T., Tribouilloy, C., Masri, A., Bax, J. J., Delgado, V., Girdauskas, E., Evangelista, A., Sundt, T. M., Svensson, L. G., Enriquez-Sarano, M., & Michelena, H. I. (Accepted/In press). Clinical presentation and outcomes of adults with bicuspid aortic valves: 2020 update. Progress in Cardiovascular Diseases. https://doi.org/10.1016/j.pcad.2020.05.010