Clinical predictors of exercise capacity 1 year after cardiac transplantation

Tat Chi Leung, Karla V Ballman, Thomas G. Allison, Jean A. Wagner, Lyle J. Olson, Robert P. Frantz, Brooks S. Edwards, Joseph A. Dearani, Richard C. Daly, Christopher G.A. McGregor, Richard J. Rodeheffer

Research output: Contribution to journalArticlepeer-review

45 Scopus citations

Abstract

Background: The exercise capacity of cardiac transplant recipients is reduced compared with normal controls. However, clinical variables predictive of post-transplant exercise capacity have not been well defined. The objective of the present study was to identify clinical features predictive of post-transplant exercise capacity. Methods: Ninety-five cardiac transplant recipients underwent cardiopulmonary testing at 1 year after transplant. The exercise parameters were compared with both pre-transplant values and normal subjects. The relationships between exercise parameters and clinical characteristics were analyzed. Results: Mean peak oxygen consumption (VO2) and exercise test duration at 1-year post-transplant improved significantly from 16.4 to 19.9 ml/kg/min and 5.5 to 7.6 minutes, respectively (p < 0.001), but were significantly lower than for normal controls (peak VO2 34.0 ml/kg/min; exercise duration 11.2 minutes; p < 0.001). Age- and gender-adjusted VO2 was 54% of predicted. Pre-operative body weight correlated strongly with post-transplant weight (r = 0.80, p < 0.001). Significant recipient predictors of 1-year post-transplant peak VO2 identified by multivariate regression analysis were age, male gender, body mass index, exercise peak heart rate and duration of post-operative intensive care. Donor variables did not contribute significantly to post-transplant peak VO2. Conclusions: Peak VO2 improved after cardiac transplantation but remained significantly impaired compared with normal subjects. In estimating the impact of cardiac transplantation on exercise capacity the most important pre-transplant factors to consider are age, gender and height and weight (or, alternatively, body mass index).

Original languageEnglish (US)
Pages (from-to)16-27
Number of pages12
JournalJournal of Heart and Lung Transplantation
Volume22
Issue number1
DOIs
StatePublished - Jan 1 2003

ASJC Scopus subject areas

  • Surgery
  • Pulmonary and Respiratory Medicine
  • Cardiology and Cardiovascular Medicine
  • Transplantation

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