Clinical Predictors and Prognostic Impact of Recovery of Wall Motion Abnormalities in Takotsubo Syndrome: Results From the International Takotsubo Registry

Stjepan Jurisic; Sebastiano Gili; Victoria L. Cammann; Ken Kato; Konrad A. Szawan; Fabrizio D'Ascenzo; Milosz Jaguszewski; Eduardo Bossone; Rodolfo Citro; Annahita Sarcon; L. Christian Napp; Jennifer Franke; Michel Noutsias; Maike Knorr; Susanne Heiner; Christof Burgdorf; Wolfgang Koenig; Alexander Pott; Behrouz Kherad; Lawrence Rajan; Guido Michels; Roman Pfister; Alessandro Cuneo; Claudius Jacobshagen; Mahir Karakas; Philippe Meyer; Jose David Arroja; Adrian Banning; Florim Cuculi; Richard Kobza; Thomas A. Fischer; Tuija Vasankari; K. E.Juhani Airaksinen; Rafal Dworakowski; Christoph Kaiser; Stefan Osswald; Leonarda Galiuto; Wolfgang Dichtl; Christina Chan; Paul Bridgman; Daniel Beug; Clément Delmas; Olivier Lairez; Martin Kozel; Petr Tousek; David E. Winchester; Ekaterina Gilyarova; Alexandra Shilova; Mikhail Gilyarov; Ibrahim El-Battrawy; Ibrahim Akin; Jan Galuszka; Christian Ukena; Gregor Poglajen; Carla Paolini; Claudio Bilato; Pedro Carrilho-Ferreira; Fausto J. Pinto; Grzegorz Opolski; Philip MacCarthy; Yoshio Kobayashi; Abhiram Prasad; Charanjit S. Rihal; Petr Widimský; John D. Horowitz; Carlo Di Mario; Filippo Crea; Carsten Tschöpe; Burkert M. Pieske; Gerd Hasenfuß; Wolfgang Rottbauer; Ruediger C. Braun-Dullaeus; Stephan B. Felix; Martin Borggrefe; Holger Thiele; Johann Bauersachs; Hugo A. Katus; Heribert Schunkert; Thomas Münzel; Michael Böhm; Jeroen J. Bax; Thomas F. Lüscher; Frank Ruschitzka; Jelena R. Ghadri; Christian Templin

doi:10.1161/JAHA.118.011194

Clinical Predictors and Prognostic Impact of Recovery of Wall Motion Abnormalities in Takotsubo Syndrome: Results From the International Takotsubo Registry

Stjepan Jurisic, Sebastiano Gili, Victoria L. Cammann, Ken Kato, Konrad A. Szawan, Fabrizio D'Ascenzo, Milosz Jaguszewski, Eduardo Bossone, Rodolfo Citro, Annahita Sarcon, L. Christian Napp, Jennifer Franke, Michel Noutsias, Maike Knorr, Susanne Heiner, Christof Burgdorf, Wolfgang Koenig, Alexander Pott, Behrouz Kherad, Lawrence RajanGuido Michels, Roman Pfister, Alessandro Cuneo, Claudius Jacobshagen, Mahir Karakas, Philippe Meyer, Jose David Arroja, Adrian Banning, Florim Cuculi, Richard Kobza, Thomas A. Fischer, Tuija Vasankari, K. E.Juhani Airaksinen, Rafal Dworakowski, Christoph Kaiser, Stefan Osswald, Leonarda Galiuto, Wolfgang Dichtl, Christina Chan, Paul Bridgman, Daniel Beug, Clément Delmas, Olivier Lairez, Martin Kozel, Petr Tousek, David E. Winchester, Ekaterina Gilyarova, Alexandra Shilova, Mikhail Gilyarov, Ibrahim El-Battrawy, Ibrahim Akin, Jan Galuszka, Christian Ukena, Gregor Poglajen, Carla Paolini, Claudio Bilato, Pedro Carrilho-Ferreira, Fausto J. Pinto, Grzegorz Opolski, Philip MacCarthy, Yoshio Kobayashi, Abhiram Prasad, Charanjit S. Rihal, Petr Widimský, John D. Horowitz, Carlo Di Mario, Filippo Crea, Carsten Tschöpe, Burkert M. Pieske, Gerd Hasenfuß, Wolfgang Rottbauer, Ruediger C. Braun-Dullaeus, Stephan B. Felix, Martin Borggrefe, Holger Thiele, Johann Bauersachs, Hugo A. Katus, Heribert Schunkert, Thomas Münzel, Michael Böhm, Jeroen J. Bax, Thomas F. Lüscher, Frank Ruschitzka, Jelena R. Ghadri, Christian Templin

Cardiovascular Medicine

Research output: Contribution to journal › Article › peer-review

6 Scopus citations

Abstract

Background: Left ventricular (LV) recovery in takotsubo syndrome (TTS) occurs over a wide-ranging interval, varying from hours to weeks. We sought to investigate the clinical predictors and prognostic impact of recovery time for TTS patients. Methods and Results: TTS patients from the International Takotsubo Registry were included in this study. Cut-off for early LV recovery was determined to be 10 days after the acute event. Multivariable logistic regression was used to assess factors associated with the absence of early recovery. In-hospital outcomes and 1-year mortality were compared for patients with versus without early recovery. We analyzed 406 patients with comprehensive and serial imaging data regarding time to recovery. Of these, 191 (47.0%) had early LV recovery and 215 (53.0%) demonstrated late LV improvement. Patients without early recovery were more often male (12.6% versus 5.2%; P=0.011) and presented more frequently with typical TTS (76.3% versus 67.0%, P=0.040). Cardiac and inflammatory markers were higher in patients without early recovery than in those with early recovery. Patients without early recovery showed unfavorable 1-year outcome compared with patients with early recovery (P=0.003). On multiple logistic regression, male sex, LV ejection fraction <45%, and acute neurologic disorders were associated with the absence of early recovery. Conclusions: TTS patients without early LV recovery have different clinical characteristics and less favorable 1-year outcome compared with patients with early recovery. The factors associated with the absence of early recovery included male sex, reduced LV ejection fraction, and acute neurologic events. Clinical Trial Registration: URL: http://www.clinicaltrials.gov. Unique identifier: NCT01947621.

Original language	English (US)
Article number	e011194
Journal	Journal of the American Heart Association
Volume	8
Issue number	21
DOIs	https://doi.org/10.1161/JAHA.118.011194
State	Published - Nov 5 2019

Keywords

outcome
recovery
takotsubo syndrome
wall motion abnormalities

ASJC Scopus subject areas

Cardiology and Cardiovascular Medicine

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10.1161/JAHA.118.011194

Cite this

Jurisic, S., Gili, S., Cammann, V. L., Kato, K., Szawan, K. A., D'Ascenzo, F., Jaguszewski, M., Bossone, E., Citro, R., Sarcon, A., Napp, L. C., Franke, J., Noutsias, M., Knorr, M., Heiner, S., Burgdorf, C., Koenig, W., Pott, A., Kherad, B., ... Templin, C. (2019). Clinical Predictors and Prognostic Impact of Recovery of Wall Motion Abnormalities in Takotsubo Syndrome: Results From the International Takotsubo Registry. Journal of the American Heart Association, 8(21), Article e011194. https://doi.org/10.1161/JAHA.118.011194

Clinical Predictors and Prognostic Impact of Recovery of Wall Motion Abnormalities in Takotsubo Syndrome: Results From the International Takotsubo Registry. / Jurisic, Stjepan; Gili, Sebastiano; Cammann, Victoria L. et al.
In: Journal of the American Heart Association, Vol. 8, No. 21, e011194, 05.11.2019.

Research output: Contribution to journal › Article › peer-review

Jurisic, S, Gili, S, Cammann, VL, Kato, K, Szawan, KA, D'Ascenzo, F, Jaguszewski, M, Bossone, E, Citro, R, Sarcon, A, Napp, LC, Franke, J, Noutsias, M, Knorr, M, Heiner, S, Burgdorf, C, Koenig, W, Pott, A, Kherad, B, Rajan, L, Michels, G, Pfister, R, Cuneo, A, Jacobshagen, C, Karakas, M, Meyer, P, Arroja, JD, Banning, A, Cuculi, F, Kobza, R, Fischer, TA, Vasankari, T, Airaksinen, KEJ, Dworakowski, R, Kaiser, C, Osswald, S, Galiuto, L, Dichtl, W, Chan, C, Bridgman, P, Beug, D, Delmas, C, Lairez, O, Kozel, M, Tousek, P, Winchester, DE, Gilyarova, E, Shilova, A, Gilyarov, M, El-Battrawy, I, Akin, I, Galuszka, J, Ukena, C, Poglajen, G, Paolini, C, Bilato, C, Carrilho-Ferreira, P, Pinto, FJ, Opolski, G, MacCarthy, P, Kobayashi, Y, Prasad, A, Rihal, CS, Widimský, P, Horowitz, JD, Di Mario, C, Crea, F, Tschöpe, C, Pieske, BM, Hasenfuß, G, Rottbauer, W, Braun-Dullaeus, RC, Felix, SB, Borggrefe, M, Thiele, H, Bauersachs, J, Katus, HA, Schunkert, H, Münzel, T, Böhm, M, Bax, JJ, Lüscher, TF, Ruschitzka, F, Ghadri, JR & Templin, C 2019, 'Clinical Predictors and Prognostic Impact of Recovery of Wall Motion Abnormalities in Takotsubo Syndrome: Results From the International Takotsubo Registry', Journal of the American Heart Association, vol. 8, no. 21, e011194. https://doi.org/10.1161/JAHA.118.011194

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title = "Clinical Predictors and Prognostic Impact of Recovery of Wall Motion Abnormalities in Takotsubo Syndrome: Results From the International Takotsubo Registry",

abstract = "Background: Left ventricular (LV) recovery in takotsubo syndrome (TTS) occurs over a wide-ranging interval, varying from hours to weeks. We sought to investigate the clinical predictors and prognostic impact of recovery time for TTS patients. Methods and Results: TTS patients from the International Takotsubo Registry were included in this study. Cut-off for early LV recovery was determined to be 10 days after the acute event. Multivariable logistic regression was used to assess factors associated with the absence of early recovery. In-hospital outcomes and 1-year mortality were compared for patients with versus without early recovery. We analyzed 406 patients with comprehensive and serial imaging data regarding time to recovery. Of these, 191 (47.0%) had early LV recovery and 215 (53.0%) demonstrated late LV improvement. Patients without early recovery were more often male (12.6% versus 5.2%; P=0.011) and presented more frequently with typical TTS (76.3% versus 67.0%, P=0.040). Cardiac and inflammatory markers were higher in patients without early recovery than in those with early recovery. Patients without early recovery showed unfavorable 1-year outcome compared with patients with early recovery (P=0.003). On multiple logistic regression, male sex, LV ejection fraction <45%, and acute neurologic disorders were associated with the absence of early recovery. Conclusions: TTS patients without early LV recovery have different clinical characteristics and less favorable 1-year outcome compared with patients with early recovery. The factors associated with the absence of early recovery included male sex, reduced LV ejection fraction, and acute neurologic events. Clinical Trial Registration: URL: http://www.clinicaltrials.gov. Unique identifier: NCT01947621.",

keywords = "outcome, recovery, takotsubo syndrome, wall motion abnormalities",

author = "Stjepan Jurisic and Sebastiano Gili and Cammann, {Victoria L.} and Ken Kato and Szawan, {Konrad A.} and Fabrizio D'Ascenzo and Milosz Jaguszewski and Eduardo Bossone and Rodolfo Citro and Annahita Sarcon and Napp, {L. Christian} and Jennifer Franke and Michel Noutsias and Maike Knorr and Susanne Heiner and Christof Burgdorf and Wolfgang Koenig and Alexander Pott and Behrouz Kherad and Lawrence Rajan and Guido Michels and Roman Pfister and Alessandro Cuneo and Claudius Jacobshagen and Mahir Karakas and Philippe Meyer and Arroja, {Jose David} and Adrian Banning and Florim Cuculi and Richard Kobza and Fischer, {Thomas A.} and Tuija Vasankari and Airaksinen, {K. E.Juhani} and Rafal Dworakowski and Christoph Kaiser and Stefan Osswald and Leonarda Galiuto and Wolfgang Dichtl and Christina Chan and Paul Bridgman and Daniel Beug and Cl{\'e}ment Delmas and Olivier Lairez and Martin Kozel and Petr Tousek and Winchester, {David E.} and Ekaterina Gilyarova and Alexandra Shilova and Mikhail Gilyarov and Ibrahim El-Battrawy and Ibrahim Akin and Jan Galuszka and Christian Ukena and Gregor Poglajen and Carla Paolini and Claudio Bilato and Pedro Carrilho-Ferreira and Pinto, {Fausto J.} and Grzegorz Opolski and Philip MacCarthy and Yoshio Kobayashi and Abhiram Prasad and Rihal, {Charanjit S.} and Petr Widimsk{\'y} and Horowitz, {John D.} and {Di Mario}, Carlo and Filippo Crea and Carsten Tsch{\"o}pe and Pieske, {Burkert M.} and Gerd Hasenfu{\ss} and Wolfgang Rottbauer and Braun-Dullaeus, {Ruediger C.} and Felix, {Stephan B.} and Martin Borggrefe and Holger Thiele and Johann Bauersachs and Katus, {Hugo A.} and Heribert Schunkert and Thomas M{\"u}nzel and Michael B{\"o}hm and Bax, {Jeroen J.} and L{\"u}scher, {Thomas F.} and Frank Ruschitzka and Ghadri, {Jelena R.} and Christian Templin",

note = "Publisher Copyright: {\textcopyright} 2019 The Authors. Published on behalf of the American Heart Association, Inc., by Wiley.",

year = "2019",

month = nov,

day = "5",

doi = "10.1161/JAHA.118.011194",

language = "English (US)",

volume = "8",

journal = "Journal of the American Heart Association",

issn = "2047-9980",

publisher = "Wiley-Blackwell",

number = "21",

}

TY - JOUR

T1 - Clinical Predictors and Prognostic Impact of Recovery of Wall Motion Abnormalities in Takotsubo Syndrome

T2 - Results From the International Takotsubo Registry

AU - Jurisic, Stjepan

AU - Gili, Sebastiano

AU - Cammann, Victoria L.

AU - Kato, Ken

AU - Szawan, Konrad A.

AU - D'Ascenzo, Fabrizio

AU - Jaguszewski, Milosz

AU - Bossone, Eduardo

AU - Citro, Rodolfo

AU - Sarcon, Annahita

AU - Napp, L. Christian

AU - Franke, Jennifer

AU - Noutsias, Michel

AU - Knorr, Maike

AU - Heiner, Susanne

AU - Burgdorf, Christof

AU - Koenig, Wolfgang

AU - Pott, Alexander

AU - Kherad, Behrouz

AU - Rajan, Lawrence

AU - Michels, Guido

AU - Pfister, Roman

AU - Cuneo, Alessandro

AU - Jacobshagen, Claudius

AU - Karakas, Mahir

AU - Meyer, Philippe

AU - Arroja, Jose David

AU - Banning, Adrian

AU - Cuculi, Florim

AU - Kobza, Richard

AU - Fischer, Thomas A.

AU - Vasankari, Tuija

AU - Airaksinen, K. E.Juhani

AU - Dworakowski, Rafal

AU - Kaiser, Christoph

AU - Osswald, Stefan

AU - Galiuto, Leonarda

AU - Dichtl, Wolfgang

AU - Chan, Christina

AU - Bridgman, Paul

AU - Beug, Daniel

AU - Delmas, Clément

AU - Lairez, Olivier

AU - Kozel, Martin

AU - Tousek, Petr

AU - Winchester, David E.

AU - Gilyarova, Ekaterina

AU - Shilova, Alexandra

AU - Gilyarov, Mikhail

AU - El-Battrawy, Ibrahim

AU - Akin, Ibrahim

AU - Galuszka, Jan

AU - Ukena, Christian

AU - Poglajen, Gregor

AU - Paolini, Carla

AU - Bilato, Claudio

AU - Carrilho-Ferreira, Pedro

AU - Pinto, Fausto J.

AU - Opolski, Grzegorz

AU - MacCarthy, Philip

AU - Kobayashi, Yoshio

AU - Prasad, Abhiram

AU - Rihal, Charanjit S.

AU - Widimský, Petr

AU - Horowitz, John D.

AU - Di Mario, Carlo

AU - Crea, Filippo

AU - Tschöpe, Carsten

AU - Pieske, Burkert M.

AU - Hasenfuß, Gerd

AU - Rottbauer, Wolfgang

AU - Braun-Dullaeus, Ruediger C.

AU - Felix, Stephan B.

AU - Borggrefe, Martin

AU - Thiele, Holger

AU - Bauersachs, Johann

AU - Katus, Hugo A.

AU - Schunkert, Heribert

AU - Münzel, Thomas

AU - Böhm, Michael

AU - Bax, Jeroen J.

AU - Lüscher, Thomas F.

AU - Ruschitzka, Frank

AU - Ghadri, Jelena R.

AU - Templin, Christian

PY - 2019/11/5

Y1 - 2019/11/5

N2 - Background: Left ventricular (LV) recovery in takotsubo syndrome (TTS) occurs over a wide-ranging interval, varying from hours to weeks. We sought to investigate the clinical predictors and prognostic impact of recovery time for TTS patients. Methods and Results: TTS patients from the International Takotsubo Registry were included in this study. Cut-off for early LV recovery was determined to be 10 days after the acute event. Multivariable logistic regression was used to assess factors associated with the absence of early recovery. In-hospital outcomes and 1-year mortality were compared for patients with versus without early recovery. We analyzed 406 patients with comprehensive and serial imaging data regarding time to recovery. Of these, 191 (47.0%) had early LV recovery and 215 (53.0%) demonstrated late LV improvement. Patients without early recovery were more often male (12.6% versus 5.2%; P=0.011) and presented more frequently with typical TTS (76.3% versus 67.0%, P=0.040). Cardiac and inflammatory markers were higher in patients without early recovery than in those with early recovery. Patients without early recovery showed unfavorable 1-year outcome compared with patients with early recovery (P=0.003). On multiple logistic regression, male sex, LV ejection fraction <45%, and acute neurologic disorders were associated with the absence of early recovery. Conclusions: TTS patients without early LV recovery have different clinical characteristics and less favorable 1-year outcome compared with patients with early recovery. The factors associated with the absence of early recovery included male sex, reduced LV ejection fraction, and acute neurologic events. Clinical Trial Registration: URL: http://www.clinicaltrials.gov. Unique identifier: NCT01947621.

AB - Background: Left ventricular (LV) recovery in takotsubo syndrome (TTS) occurs over a wide-ranging interval, varying from hours to weeks. We sought to investigate the clinical predictors and prognostic impact of recovery time for TTS patients. Methods and Results: TTS patients from the International Takotsubo Registry were included in this study. Cut-off for early LV recovery was determined to be 10 days after the acute event. Multivariable logistic regression was used to assess factors associated with the absence of early recovery. In-hospital outcomes and 1-year mortality were compared for patients with versus without early recovery. We analyzed 406 patients with comprehensive and serial imaging data regarding time to recovery. Of these, 191 (47.0%) had early LV recovery and 215 (53.0%) demonstrated late LV improvement. Patients without early recovery were more often male (12.6% versus 5.2%; P=0.011) and presented more frequently with typical TTS (76.3% versus 67.0%, P=0.040). Cardiac and inflammatory markers were higher in patients without early recovery than in those with early recovery. Patients without early recovery showed unfavorable 1-year outcome compared with patients with early recovery (P=0.003). On multiple logistic regression, male sex, LV ejection fraction <45%, and acute neurologic disorders were associated with the absence of early recovery. Conclusions: TTS patients without early LV recovery have different clinical characteristics and less favorable 1-year outcome compared with patients with early recovery. The factors associated with the absence of early recovery included male sex, reduced LV ejection fraction, and acute neurologic events. Clinical Trial Registration: URL: http://www.clinicaltrials.gov. Unique identifier: NCT01947621.

KW - outcome

KW - recovery

KW - takotsubo syndrome

KW - wall motion abnormalities

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U2 - 10.1161/JAHA.118.011194

DO - 10.1161/JAHA.118.011194

M3 - Article

C2 - 31672100

AN - SCOPUS:85074428763

SN - 2047-9980

VL - 8

JO - Journal of the American Heart Association

JF - Journal of the American Heart Association

IS - 21

M1 - e011194

ER -

Clinical Predictors and Prognostic Impact of Recovery of Wall Motion Abnormalities in Takotsubo Syndrome: Results From the International Takotsubo Registry

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