Clinical phenotype and genetic risk factors for bipolar disorder with binge eating: an update

Alfredo B. Cuellar-Barboza, Stacey J Winham, Joanna M Biernacka, Mark A Frye, Susan L. McElroy

Research output: Contribution to journalArticle

Abstract

Introduction: Clinical and genetic study of psychiatric conditions has underscored the co-occurrence of complex phenotypes and the need to refine them. Bipolar Disorder (BD) and Binge Eating (BE) behavior are common psychiatric conditions that have high heritability and high co-occurrence, such that at least one quarter of BD patients have BE (BD + BE). Genetic studies of BD alone and of BE alone suggest complex polygenic risk models, with many genetic risk loci yet to be identified. Areas covered: We review studies of the epidemiology of BD+BE, its clinical features (cognitive traits, psychiatric comorbidity, and role of obesity), genomic studies (of BD, eating disorders (ED) defined by BE, and BD + BE), and therapeutic implications of BD + BE. Expert opinion: Subphenotyping of complex psychiatric disorders reduces heterogeneity and increases statistical power and effect size; thus, it enhances our capacity to find missing genetic (and other) risk factors. BD + BE has a severe clinical picture and genetic studies suggests a distinct genetic architecture. Differential therapeutic interventions may be needed for patients with BD + BE compared with BD patients without BE. Recognizing the BD + BE subphenotype is an example of moving towards more precise clinical and genetic entities.

Original languageEnglish (US)
Pages (from-to)867-879
Number of pages13
JournalExpert review of neurotherapeutics
Volume19
Issue number9
DOIs
StatePublished - Sep 1 2019

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Bulimia
Bipolar Disorder
Phenotype
Psychiatry
Binge-Eating Disorder
Genetic Loci
Expert Testimony
Feeding Behavior
Comorbidity
Epidemiology
Obesity

Keywords

  • binge eating
  • Bipolar
  • eating disorders
  • genetics
  • GWAS

ASJC Scopus subject areas

  • Neuroscience(all)
  • Clinical Neurology
  • Pharmacology (medical)

Cite this

Clinical phenotype and genetic risk factors for bipolar disorder with binge eating : an update. / Cuellar-Barboza, Alfredo B.; Winham, Stacey J; Biernacka, Joanna M; Frye, Mark A; McElroy, Susan L.

In: Expert review of neurotherapeutics, Vol. 19, No. 9, 01.09.2019, p. 867-879.

Research output: Contribution to journalArticle

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