Clinical importance of cardiac troponin release and cardiac abnormalities in patients with supratentorial cerebral hemorrhages

Boby V. Maramattom, Edward M. Manno, Jimmy R. Fulgham, Allan S Jaffe, Eelco F M Wijdicks

Research output: Contribution to journalArticle

31 Citations (Scopus)

Abstract

OBJECTIVE: To determine the incidence of cardiac troponin T (cTnT) elevation, electrocardiographic (ECG) changes, and arrhythmias in supratentorial intracerebral hemorrhage (ICH) and their association with early mortality. PATIENTS AND METHODS: Patients with supratentorial ICHs admitted to Mayo Clinic, Rochester, Minn, from March 1998 to October 2003 were-studied. We excluded moribund patients with ICHs who died within 12 hours of hospital admission. Cardiac troponin T levels measured on admission and day 2 were determined by a third-generation enzyme-linked immunosorbent assay. Continuous ECG monitoring was performed in all patients. Computed tomographic scans were graded and correlated with abnormal cardiac variables. RESULTS: Peak levels of cTnT were elevated at 0.035 to 1.2 μg/L (mean ± SD, 0.27±0.38 μg/L) in 10 (20%) of 49 patients and were not associated with changes in creatine kinase MB fraction or ECG results. The cTnT levels did not correlate with location or side of hemorrhage or mortality at 30 days. Seventy (64%) of 110 patients displayed ECG abnormalities. The ECG changes did not correlate with the location or side of ICH, hydrocephalus, midline shift, or extension to the ventricles. CONCLUSION: The cTnT elevations in survivors of acute ICH are frequent but without confirmatory ECG changes that suggest mild myocardial injury. One-month mortality is not influenced by such cTnT elevations. In addition, ECG abnormalities are common but likely benign in patients with supratentorial ICH who survive the initial insult.

Original languageEnglish (US)
Pages (from-to)192-196
Number of pages5
JournalMayo Clinic Proceedings
Volume81
Issue number2
DOIs
StatePublished - 2006

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Troponin T
Troponin
Cerebral Hemorrhage
Mortality
MB Form Creatine Kinase
Hydrocephalus
Survivors
Cardiac Arrhythmias
Enzyme-Linked Immunosorbent Assay
Hemorrhage
Incidence
Wounds and Injuries

ASJC Scopus subject areas

  • Medicine(all)

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Clinical importance of cardiac troponin release and cardiac abnormalities in patients with supratentorial cerebral hemorrhages. / Maramattom, Boby V.; Manno, Edward M.; Fulgham, Jimmy R.; Jaffe, Allan S; Wijdicks, Eelco F M.

In: Mayo Clinic Proceedings, Vol. 81, No. 2, 2006, p. 192-196.

Research output: Contribution to journalArticle

Maramattom, Boby V. ; Manno, Edward M. ; Fulgham, Jimmy R. ; Jaffe, Allan S ; Wijdicks, Eelco F M. / Clinical importance of cardiac troponin release and cardiac abnormalities in patients with supratentorial cerebral hemorrhages. In: Mayo Clinic Proceedings. 2006 ; Vol. 81, No. 2. pp. 192-196.
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