Clinical factors asssociated with treatment outcomes following whole-brain irradiation in patients with prostate cancer

Liesa Dziggel, Steven E. Schild, Theo Veninga, Amira Bajrovic, Dirk Rades

Research output: Contribution to journalArticle

9 Scopus citations

Abstract

Background/Aim: Patients with prostate cancer represent a small minority of cancer patients presenting with metastases to the brain. This study investigated the role of whole-brain irradiation (WBI) in this rare group. Patients and Methods: Eighteen such patients were included. Clinical factors including fractionation program of WBI, age at WBI, Karnofsky performance score (KPS), number of metastases to the brain, involvement of extracerebral metastatic sites, time from prostate cancer diagnosis to WBI and recursivepartitioning-analysis (RPA) class were investigated regarding local (intracerebral) control and survival. Results: On multivariate evaluation, longer time from prostate cancer diagnosis to WBI showed a trend towards improved local control (hazard ratio 2.77, p=0.098). Better KPS (hazard ratio 5.64, p=0.021) and longer time from prostate cancer diagnosis to WBI (hazard ratio 5.64, p=0.013) were significantly associated with better survival. Conclusion: Two independent predictors of survival were identified and should be considered when designing for personalized treatment regimens and clinical trials.

Original languageEnglish (US)
Pages (from-to)35-38
Number of pages4
JournalIn Vivo
Volume31
Issue number1
DOIs
StatePublished - 2017

Keywords

  • Local control
  • Metastases to the brain
  • Prostate cancer
  • Survival.
  • WBI

ASJC Scopus subject areas

  • Biochemistry, Genetics and Molecular Biology(all)
  • Pharmacology

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