Clinical evaluation of T2 values of patellar cartilage in patients with osteoarthritis

M. F. Koff, K. K. Amrami, Kenton R Kaufman

Research output: Contribution to journalArticle

68 Citations (Scopus)

Abstract

Objective: The transverse relaxation time constant, T2, of articular cartilage has been proposed as a biomarker for osteoarthritis (OA). Previous studies have not clearly defined the relationship between cartilage T2 values and clinical methods of grading OA or known factors associated with OA. This study compared T2 values of patellar cartilage grouped by radiographic stage of patello-femoral OA and by body mass index (BMI). Methods: T2 values of patellar cartilage were calculated for 113 subjects using images acquired on a 1.5 T clinical scanner. Radiographs of the patello-femoral joint were graded for OA grading using the Kellgren-Lawrence scale. Results: No differences of T2 values were found across the stages of OA (P = 0.25), but the factor of BMI did have a significant effect (P < 0.0001) on T2 value. Conclusions: The results indicate the T2 values are not sensitive to changes in radiographic stages of OA. In addition, differences of T2 values with BMI signify structural changes occurring within the patello-femoral joint and that BMI may be considered a factor for a potential increase of T2 values. Future studies comparing different OA grading methods with T2 mapping may highlight the sensitivity of T2 mapping in a clinical setting.

Original languageEnglish (US)
Pages (from-to)198-204
Number of pages7
JournalOsteoarthritis and Cartilage
Volume15
Issue number2
DOIs
StatePublished - Feb 2007

Fingerprint

Cartilage
Osteoarthritis
Body Mass Index
Thigh
Biomarkers
Relaxation time
Joints
Articular Cartilage

Keywords

  • MRI
  • Osteoarthritis
  • Patella
  • Radiography
  • T

ASJC Scopus subject areas

  • Orthopedics and Sports Medicine

Cite this

Clinical evaluation of T2 values of patellar cartilage in patients with osteoarthritis. / Koff, M. F.; Amrami, K. K.; Kaufman, Kenton R.

In: Osteoarthritis and Cartilage, Vol. 15, No. 2, 02.2007, p. 198-204.

Research output: Contribution to journalArticle

@article{fcc88e0397804c1dbe3c3e95fc0a0d53,
title = "Clinical evaluation of T2 values of patellar cartilage in patients with osteoarthritis",
abstract = "Objective: The transverse relaxation time constant, T2, of articular cartilage has been proposed as a biomarker for osteoarthritis (OA). Previous studies have not clearly defined the relationship between cartilage T2 values and clinical methods of grading OA or known factors associated with OA. This study compared T2 values of patellar cartilage grouped by radiographic stage of patello-femoral OA and by body mass index (BMI). Methods: T2 values of patellar cartilage were calculated for 113 subjects using images acquired on a 1.5 T clinical scanner. Radiographs of the patello-femoral joint were graded for OA grading using the Kellgren-Lawrence scale. Results: No differences of T2 values were found across the stages of OA (P = 0.25), but the factor of BMI did have a significant effect (P < 0.0001) on T2 value. Conclusions: The results indicate the T2 values are not sensitive to changes in radiographic stages of OA. In addition, differences of T2 values with BMI signify structural changes occurring within the patello-femoral joint and that BMI may be considered a factor for a potential increase of T2 values. Future studies comparing different OA grading methods with T2 mapping may highlight the sensitivity of T2 mapping in a clinical setting.",
keywords = "MRI, Osteoarthritis, Patella, Radiography, T",
author = "Koff, {M. F.} and Amrami, {K. K.} and Kaufman, {Kenton R}",
year = "2007",
month = "2",
doi = "10.1016/j.joca.2006.07.007",
language = "English (US)",
volume = "15",
pages = "198--204",
journal = "Osteoarthritis and Cartilage",
issn = "1063-4584",
publisher = "W.B. Saunders Ltd",
number = "2",

}

TY - JOUR

T1 - Clinical evaluation of T2 values of patellar cartilage in patients with osteoarthritis

AU - Koff, M. F.

AU - Amrami, K. K.

AU - Kaufman, Kenton R

PY - 2007/2

Y1 - 2007/2

N2 - Objective: The transverse relaxation time constant, T2, of articular cartilage has been proposed as a biomarker for osteoarthritis (OA). Previous studies have not clearly defined the relationship between cartilage T2 values and clinical methods of grading OA or known factors associated with OA. This study compared T2 values of patellar cartilage grouped by radiographic stage of patello-femoral OA and by body mass index (BMI). Methods: T2 values of patellar cartilage were calculated for 113 subjects using images acquired on a 1.5 T clinical scanner. Radiographs of the patello-femoral joint were graded for OA grading using the Kellgren-Lawrence scale. Results: No differences of T2 values were found across the stages of OA (P = 0.25), but the factor of BMI did have a significant effect (P < 0.0001) on T2 value. Conclusions: The results indicate the T2 values are not sensitive to changes in radiographic stages of OA. In addition, differences of T2 values with BMI signify structural changes occurring within the patello-femoral joint and that BMI may be considered a factor for a potential increase of T2 values. Future studies comparing different OA grading methods with T2 mapping may highlight the sensitivity of T2 mapping in a clinical setting.

AB - Objective: The transverse relaxation time constant, T2, of articular cartilage has been proposed as a biomarker for osteoarthritis (OA). Previous studies have not clearly defined the relationship between cartilage T2 values and clinical methods of grading OA or known factors associated with OA. This study compared T2 values of patellar cartilage grouped by radiographic stage of patello-femoral OA and by body mass index (BMI). Methods: T2 values of patellar cartilage were calculated for 113 subjects using images acquired on a 1.5 T clinical scanner. Radiographs of the patello-femoral joint were graded for OA grading using the Kellgren-Lawrence scale. Results: No differences of T2 values were found across the stages of OA (P = 0.25), but the factor of BMI did have a significant effect (P < 0.0001) on T2 value. Conclusions: The results indicate the T2 values are not sensitive to changes in radiographic stages of OA. In addition, differences of T2 values with BMI signify structural changes occurring within the patello-femoral joint and that BMI may be considered a factor for a potential increase of T2 values. Future studies comparing different OA grading methods with T2 mapping may highlight the sensitivity of T2 mapping in a clinical setting.

KW - MRI

KW - Osteoarthritis

KW - Patella

KW - Radiography

KW - T

UR - http://www.scopus.com/inward/record.url?scp=33846543655&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=33846543655&partnerID=8YFLogxK

U2 - 10.1016/j.joca.2006.07.007

DO - 10.1016/j.joca.2006.07.007

M3 - Article

C2 - 16949313

AN - SCOPUS:33846543655

VL - 15

SP - 198

EP - 204

JO - Osteoarthritis and Cartilage

JF - Osteoarthritis and Cartilage

SN - 1063-4584

IS - 2

ER -