Clinical Chemistry of Patients with Ebola in Monrovia, Liberia

Emmie De Wit, Shelby Kramer, Joseph Prescott, Kyle Rosenke, Darryl Falzarano, Andrea Marzi, Robert J. Fischer, David Safronetz, Thomas Hoenen, Allison Groseth, Neeltje Van Doremalen, Trenton Bushmaker, Kristin L. McNally, Friederike Feldmann, Brandi N. Williamson, Sonja M. Best, Hideki Ebihara, Igor A.C. Damiani, Brett Adamson, Kathryn C. ZoonTolbert G. Nyenswah, Fatorma K. Bolay, Moses Massaquoi, Armand Sprecher, Heinz Feldmann, Vincent J. Munster

Research output: Contribution to journalArticle

6 Citations (Scopus)

Abstract

The development of point-of-care clinical chemistry analyzers has enabled the implementation of these ancillary tests in field laboratories in resource-limited outbreak areas. The Eternal Love Winning Africa (ELWA) outbreak diagnostic laboratory, established in Monrovia, Liberia, to provide Ebola virus and Plasmodium spp. diagnostics during the Ebola epidemic, implemented clinical chemistry analyzers in December 2014. Clinical chemistry testing was performed for 68 patients in triage, including 12 patients infected with Ebola virus and 18 infected with Plasmodium spp. The main distinguishing feature in clinical chemistry of Ebola virus-infected patients was the elevation in alanine aminotransferase, aspartate aminotransferase, alkaline phosphatase, and γ-glutamyltransferase levels and the decrease in calcium. The implementation of clinical chemistry is probably most helpful when the medical supportive care implemented at the Ebola treatment unit allows for correction of biochemistry derangements and on-site clinical chemistry analyzers can be used to monitor electrolyte balance.

Original languageEnglish (US)
Pages (from-to)S303-S307
JournalJournal of Infectious Diseases
Volume214
DOIs
StatePublished - Oct 15 2016
Externally publishedYes

Fingerprint

Liberia
Clinical Chemistry
Ebolavirus
Plasmodium
Disease Outbreaks
Point-of-Care Systems
Water-Electrolyte Balance
Love
Triage
Aspartate Aminotransferases
Alanine Transaminase
Biochemistry
Alkaline Phosphatase
Calcium

Keywords

  • Clinical chemistry
  • Ebola virus
  • West Africa

ASJC Scopus subject areas

  • Immunology and Allergy
  • Infectious Diseases

Cite this

De Wit, E., Kramer, S., Prescott, J., Rosenke, K., Falzarano, D., Marzi, A., ... Munster, V. J. (2016). Clinical Chemistry of Patients with Ebola in Monrovia, Liberia. Journal of Infectious Diseases, 214, S303-S307. https://doi.org/10.1093/infdis/jiw187

Clinical Chemistry of Patients with Ebola in Monrovia, Liberia. / De Wit, Emmie; Kramer, Shelby; Prescott, Joseph; Rosenke, Kyle; Falzarano, Darryl; Marzi, Andrea; Fischer, Robert J.; Safronetz, David; Hoenen, Thomas; Groseth, Allison; Van Doremalen, Neeltje; Bushmaker, Trenton; McNally, Kristin L.; Feldmann, Friederike; Williamson, Brandi N.; Best, Sonja M.; Ebihara, Hideki; Damiani, Igor A.C.; Adamson, Brett; Zoon, Kathryn C.; Nyenswah, Tolbert G.; Bolay, Fatorma K.; Massaquoi, Moses; Sprecher, Armand; Feldmann, Heinz; Munster, Vincent J.

In: Journal of Infectious Diseases, Vol. 214, 15.10.2016, p. S303-S307.

Research output: Contribution to journalArticle

De Wit, E, Kramer, S, Prescott, J, Rosenke, K, Falzarano, D, Marzi, A, Fischer, RJ, Safronetz, D, Hoenen, T, Groseth, A, Van Doremalen, N, Bushmaker, T, McNally, KL, Feldmann, F, Williamson, BN, Best, SM, Ebihara, H, Damiani, IAC, Adamson, B, Zoon, KC, Nyenswah, TG, Bolay, FK, Massaquoi, M, Sprecher, A, Feldmann, H & Munster, VJ 2016, 'Clinical Chemistry of Patients with Ebola in Monrovia, Liberia', Journal of Infectious Diseases, vol. 214, pp. S303-S307. https://doi.org/10.1093/infdis/jiw187
De Wit E, Kramer S, Prescott J, Rosenke K, Falzarano D, Marzi A et al. Clinical Chemistry of Patients with Ebola in Monrovia, Liberia. Journal of Infectious Diseases. 2016 Oct 15;214:S303-S307. https://doi.org/10.1093/infdis/jiw187
De Wit, Emmie ; Kramer, Shelby ; Prescott, Joseph ; Rosenke, Kyle ; Falzarano, Darryl ; Marzi, Andrea ; Fischer, Robert J. ; Safronetz, David ; Hoenen, Thomas ; Groseth, Allison ; Van Doremalen, Neeltje ; Bushmaker, Trenton ; McNally, Kristin L. ; Feldmann, Friederike ; Williamson, Brandi N. ; Best, Sonja M. ; Ebihara, Hideki ; Damiani, Igor A.C. ; Adamson, Brett ; Zoon, Kathryn C. ; Nyenswah, Tolbert G. ; Bolay, Fatorma K. ; Massaquoi, Moses ; Sprecher, Armand ; Feldmann, Heinz ; Munster, Vincent J. / Clinical Chemistry of Patients with Ebola in Monrovia, Liberia. In: Journal of Infectious Diseases. 2016 ; Vol. 214. pp. S303-S307.
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