Clinical characteristics of gastrointestinal lymphomas associated with AIDS (GI-ARL) and the impact of HAART

Sridhar Srinivasan, Kenichi Takeshita, Beata Holkova, Myron S. Czuczman, Kena Miller, Zale P. Bernstein, Deborah Driscoll, Asher Chanan-Khan

Research output: Contribution to journalArticle

3 Scopus citations

Abstract

Purpose: The gastrointestinal (GI) tract is the most common site of extranodal disease in patients with systemic non-Hodgkin's lymphoma (NHL). Patients with systemic NHL and GI involvement associated with AIDS (GI-ARL) have a significantly worse prognosis than those without AIDS. We studied whether the introduction of HAART is associated with improved survival in patients with GI-ARL. Patients and Method: 36 patients with GI-ARL were identified from the tumor registries of a large municipal hospital in New York City and a tertiary care facility in western New York State. Of these, 28 patients did not receive HAART and 8 were treated with HAART. The primary endpoint was survival, which was defined as time from date of diagnosis of NHL until death from any cause. Results: Patients were analyzed based on whether or not they were treated with HAART. Kaplan-Meier analyst showed significantly better survival in patients with GI-ARL who were concurrently treated with HAART (p = .014). Median survival was 5 months for the no-HAART group and 30 months for the HAART group. Conclusion: In patients with GI-ARL who were treated with chemotherapy, concurrent therapy with HAART therapy was associated with improved survival.

Original languageEnglish (US)
Pages (from-to)140-145
Number of pages6
JournalHIV Clinical Trials
Volume5
Issue number3
DOIs
StatePublished - May 1 2004

Keywords

  • Gastrointestinal
  • HAART
  • HIV
  • Lymphoma

ASJC Scopus subject areas

  • Infectious Diseases
  • Pharmacology (medical)

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    Srinivasan, S., Takeshita, K., Holkova, B., Czuczman, M. S., Miller, K., Bernstein, Z. P., Driscoll, D., & Chanan-Khan, A. (2004). Clinical characteristics of gastrointestinal lymphomas associated with AIDS (GI-ARL) and the impact of HAART. HIV Clinical Trials, 5(3), 140-145. https://doi.org/10.1310/BDHX-D9BC-YWVU-9NBR