TY - JOUR
T1 - Clinical characteristics of familial vs. sporadic non-Hodgkin lymphoma in patients diagnosed at the Mayo Clinic (1986-2000)
AU - Vachon, Celine M.
AU - Habermann, Thomas M.
AU - Kurtin, Paul J.
AU - Cerhan, James R.
PY - 2004/5
Y1 - 2004/5
N2 - There are few data on the clinical characteristics of familial vs. sporadic non-Hodgkin lymphoma (NHL). Using the NHL registry at the Mayo Clinic, we compared age of diagnosis, gender, tumor site and histologic subtype between patients with sporadic and familial NHL. In 2001, we identified all new cases of adult NHL diagnosed between 1986 and 2000 in the Mayo Clinic NHL database (n = 2,289) and mailed out a family history questionnaire to all living patients with a current address (n = 1,043). Each NHL patient was categorized according to their self-report of leukemia or lymphoma in first-degree (1°) relatives. We received complete FH information on 740 patients (71 %). Age at diagnosis of NHL ranged from 18-88 years (mean = 59 years) and 53% of our cases were male. First-degree FH of lymphoma was reported by 43 patients (6%), 1° FH of leukemia by 27 patients (4%) and 1° FH of both in 4 (1%). There was a nonstatistically significant later age at diagnosis for cases with any family history of lymphoma or leukemia (mean age = 61.3 and 61.7 years, respectively) vs. no family history (59.0 years) (P = 0.58). The male to female ratio for those with a FH of leukemia (ratio = 2.9) was higher compared to those with FH lymphoma (0.95) or no FH (1.1) (P = 0.08). No differences were apparent between 1° FH and site of NHL (nodal vs. extranodal) (P = 0.53). Among recently diagnosed cases (since 1995), there was some suggestion of a greater proportion of aggressive tumors for those with any family history (69% and 55%) vs. none (50%) (P = 0.20). We found little evidence of large differences between familial and sporadic NHL with regard to age, gender, site or histologic subtype.
AB - There are few data on the clinical characteristics of familial vs. sporadic non-Hodgkin lymphoma (NHL). Using the NHL registry at the Mayo Clinic, we compared age of diagnosis, gender, tumor site and histologic subtype between patients with sporadic and familial NHL. In 2001, we identified all new cases of adult NHL diagnosed between 1986 and 2000 in the Mayo Clinic NHL database (n = 2,289) and mailed out a family history questionnaire to all living patients with a current address (n = 1,043). Each NHL patient was categorized according to their self-report of leukemia or lymphoma in first-degree (1°) relatives. We received complete FH information on 740 patients (71 %). Age at diagnosis of NHL ranged from 18-88 years (mean = 59 years) and 53% of our cases were male. First-degree FH of lymphoma was reported by 43 patients (6%), 1° FH of leukemia by 27 patients (4%) and 1° FH of both in 4 (1%). There was a nonstatistically significant later age at diagnosis for cases with any family history of lymphoma or leukemia (mean age = 61.3 and 61.7 years, respectively) vs. no family history (59.0 years) (P = 0.58). The male to female ratio for those with a FH of leukemia (ratio = 2.9) was higher compared to those with FH lymphoma (0.95) or no FH (1.1) (P = 0.08). No differences were apparent between 1° FH and site of NHL (nodal vs. extranodal) (P = 0.53). Among recently diagnosed cases (since 1995), there was some suggestion of a greater proportion of aggressive tumors for those with any family history (69% and 55%) vs. none (50%) (P = 0.20). We found little evidence of large differences between familial and sporadic NHL with regard to age, gender, site or histologic subtype.
KW - Clinical
KW - Family history
KW - Lymphoma
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U2 - 10.1080/1042819032000159898
DO - 10.1080/1042819032000159898
M3 - Article
C2 - 15291351
AN - SCOPUS:1842607355
SN - 1042-8194
VL - 45
SP - 929
EP - 935
JO - Leukemia and Lymphoma
JF - Leukemia and Lymphoma
IS - 5
ER -