Clinical aspects of Marburg hemorrhagic fever

Masfique Mehedi, Allison Groseth, Heinz Feldmann, Hideki Ebihara

Research output: Contribution to journalReview article

41 Scopus citations

Abstract

Marburg virus belongs to the genus Marburgvirus in the family Filoviridae and causes a severe hemorrhagic fever, known as Marburg hemorrhagic fever (MHF), in both humans and nonhuman primates. Similar to the more widely known Ebola hemorrhagic fever, MHF is characterized by systemic viral replication, immunosuppression and abnormal inflammatory responses. These pathological features of the disease contribute to a number of systemic dysfunctions including hemorrhages, edema, coagulation abnormalities and, ultimately, multiorgan failure and shock, often resulting in death. A detailed understanding of the pathological processes that lead to this devastating disease remains elusive, a fact that contributes to the lack of licensed vaccines or effective therapeutics. This article will review the clinical aspects of MHF and discuss the pathogenesis and possible options for diagnosis, treatment and prevention.

Original languageEnglish (US)
Pages (from-to)1091-1106
Number of pages16
JournalFuture Virology
Volume6
Issue number9
DOIs
StatePublished - Sep 1 2011

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Keywords

  • Marburg virus
  • diagnosis
  • disease
  • hemorrhagic fever
  • pathogenesis
  • pathology
  • prevention
  • treatment

ASJC Scopus subject areas

  • Virology

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