Clinical, angiographic and procedural correlates of quantitative coronary dimensions after directional coronary atherectomy

Jeffrey J. Popma, Nicoletta B. De Cesare, Stephen G. Ellis, David Holmes, Cass A. Pinkerton, Patrick Whitlow, Spencer B. King, Ziyad M.B. Ghazzal, Eric J. Topol, Kirk N. Garratt, Dean J. Kereiakes

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Abstract

To define the clinical, angiographic and procedural correlates of quantitative coronary dimensions after directional coronary atherectomy, 400 lesions in 378 patients were analyzed with use of qualitative morphologic and quantitative angiographic methods. Successful atherectomy, defined by a <75% residual area stenosis, tissue retrieval and the absence of in-hospital ischemic complications, was performed in 351 lesions (87.7%). After atherectomy, minimal cross-sectional area increased from 1.2 ± 1.1 to 6.6 ± 4.4 mm 2 (p < 0.001) and percent area stenosis was reduced from 87 ± 10% to 31 ± 42% (p < 0.001). By univariate analysis, device size (p < 0.001) and left circumflex artery lesion location (p = 0.004) were associated with a larger final minimal cross-sectional area. Conversely, restenotic lesion (p = 0.002), lesion length ≥ 10 mm (p = 0.018) and lesion calcification (p = 0.035) were quantitatively associated with a smaller final minimum cross-sectional area. With use of stepwise multivariate analysis to control for the reference area, atherectomy device size (p = 0.003) and left circumflex lesion location (p = 0.007) were independently associated with a larger final minimal cross-sectional area, whereas restenotic lesion (p = 0.010), diffuse proximal disease (p = 0.033), lesion length ≥ 10 mm (p = 0.026) and lesion calcification (p = 0.081) were significantly correlated with a smaller final minimal cross-sectional area. The number of specimens excised, the number of atherectomy passes and atherectomy balloon inflation pressure did not correlate with the final minimal cross-sectional area. Thus, directional atherectomy results in marked improvement of coronary lumen dimensions, at least in part correlated with the presence of certain clinical, angiographic and procedural factors at the time of atherectomy.

Original languageEnglish (US)
Pages (from-to)1183-1189
Number of pages7
JournalJournal of the American College of Cardiology
Volume18
Issue number5
DOIs
StatePublished - Nov 1 1991

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Coronary Atherectomy
Atherectomy
Pathologic Constriction
Equipment and Supplies
Economic Inflation
Multivariate Analysis
Arteries
Pressure

ASJC Scopus subject areas

  • Cardiology and Cardiovascular Medicine

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Clinical, angiographic and procedural correlates of quantitative coronary dimensions after directional coronary atherectomy. / Popma, Jeffrey J.; De Cesare, Nicoletta B.; Ellis, Stephen G.; Holmes, David; Pinkerton, Cass A.; Whitlow, Patrick; King, Spencer B.; Ghazzal, Ziyad M.B.; Topol, Eric J.; Garratt, Kirk N.; Kereiakes, Dean J.

In: Journal of the American College of Cardiology, Vol. 18, No. 5, 01.11.1991, p. 1183-1189.

Research output: Contribution to journalArticle

Popma, JJ, De Cesare, NB, Ellis, SG, Holmes, D, Pinkerton, CA, Whitlow, P, King, SB, Ghazzal, ZMB, Topol, EJ, Garratt, KN & Kereiakes, DJ 1991, 'Clinical, angiographic and procedural correlates of quantitative coronary dimensions after directional coronary atherectomy', Journal of the American College of Cardiology, vol. 18, no. 5, pp. 1183-1189. https://doi.org/10.1016/0735-1097(91)90534-G
Popma, Jeffrey J. ; De Cesare, Nicoletta B. ; Ellis, Stephen G. ; Holmes, David ; Pinkerton, Cass A. ; Whitlow, Patrick ; King, Spencer B. ; Ghazzal, Ziyad M.B. ; Topol, Eric J. ; Garratt, Kirk N. ; Kereiakes, Dean J. / Clinical, angiographic and procedural correlates of quantitative coronary dimensions after directional coronary atherectomy. In: Journal of the American College of Cardiology. 1991 ; Vol. 18, No. 5. pp. 1183-1189.
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abstract = "To define the clinical, angiographic and procedural correlates of quantitative coronary dimensions after directional coronary atherectomy, 400 lesions in 378 patients were analyzed with use of qualitative morphologic and quantitative angiographic methods. Successful atherectomy, defined by a <75{\%} residual area stenosis, tissue retrieval and the absence of in-hospital ischemic complications, was performed in 351 lesions (87.7{\%}). After atherectomy, minimal cross-sectional area increased from 1.2 ± 1.1 to 6.6 ± 4.4 mm 2 (p < 0.001) and percent area stenosis was reduced from 87 ± 10{\%} to 31 ± 42{\%} (p < 0.001). By univariate analysis, device size (p < 0.001) and left circumflex artery lesion location (p = 0.004) were associated with a larger final minimal cross-sectional area. Conversely, restenotic lesion (p = 0.002), lesion length ≥ 10 mm (p = 0.018) and lesion calcification (p = 0.035) were quantitatively associated with a smaller final minimum cross-sectional area. With use of stepwise multivariate analysis to control for the reference area, atherectomy device size (p = 0.003) and left circumflex lesion location (p = 0.007) were independently associated with a larger final minimal cross-sectional area, whereas restenotic lesion (p = 0.010), diffuse proximal disease (p = 0.033), lesion length ≥ 10 mm (p = 0.026) and lesion calcification (p = 0.081) were significantly correlated with a smaller final minimal cross-sectional area. The number of specimens excised, the number of atherectomy passes and atherectomy balloon inflation pressure did not correlate with the final minimal cross-sectional area. Thus, directional atherectomy results in marked improvement of coronary lumen dimensions, at least in part correlated with the presence of certain clinical, angiographic and procedural factors at the time of atherectomy.",
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AU - De Cesare, Nicoletta B.

AU - Ellis, Stephen G.

AU - Holmes, David

AU - Pinkerton, Cass A.

AU - Whitlow, Patrick

AU - King, Spencer B.

AU - Ghazzal, Ziyad M.B.

AU - Topol, Eric J.

AU - Garratt, Kirk N.

AU - Kereiakes, Dean J.

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N2 - To define the clinical, angiographic and procedural correlates of quantitative coronary dimensions after directional coronary atherectomy, 400 lesions in 378 patients were analyzed with use of qualitative morphologic and quantitative angiographic methods. Successful atherectomy, defined by a <75% residual area stenosis, tissue retrieval and the absence of in-hospital ischemic complications, was performed in 351 lesions (87.7%). After atherectomy, minimal cross-sectional area increased from 1.2 ± 1.1 to 6.6 ± 4.4 mm 2 (p < 0.001) and percent area stenosis was reduced from 87 ± 10% to 31 ± 42% (p < 0.001). By univariate analysis, device size (p < 0.001) and left circumflex artery lesion location (p = 0.004) were associated with a larger final minimal cross-sectional area. Conversely, restenotic lesion (p = 0.002), lesion length ≥ 10 mm (p = 0.018) and lesion calcification (p = 0.035) were quantitatively associated with a smaller final minimum cross-sectional area. With use of stepwise multivariate analysis to control for the reference area, atherectomy device size (p = 0.003) and left circumflex lesion location (p = 0.007) were independently associated with a larger final minimal cross-sectional area, whereas restenotic lesion (p = 0.010), diffuse proximal disease (p = 0.033), lesion length ≥ 10 mm (p = 0.026) and lesion calcification (p = 0.081) were significantly correlated with a smaller final minimal cross-sectional area. The number of specimens excised, the number of atherectomy passes and atherectomy balloon inflation pressure did not correlate with the final minimal cross-sectional area. Thus, directional atherectomy results in marked improvement of coronary lumen dimensions, at least in part correlated with the presence of certain clinical, angiographic and procedural factors at the time of atherectomy.

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