Clinical and neuroimaging characteristics of clinically unclassifiable primary progressive aphasia

Rene Utianski, Hugo Botha, Peter R. Martin, Christopher Schwarz, Joseph R. Duffy, Heather Clark, Mary Margaret Machulda, Alissa Butts, Val Lowe, Clifford R Jr. Jack, Matthew L. Senjem, Anthony J. Spychalla, Jennifer Lynn Whitwell, Keith Anthony Josephs

Research output: Contribution to journalArticle

Abstract

Many patients who meet core/root criteria for Primary Progressive Aphasia (PPA) are not classifiable as a recognized variant and are often excluded from neuroimaging studies. Here, we detail neurological, neuropsychological, speech and language assessments, and anatomic and molecular neuroimaging (MRI, PiB-PET, and FDG-PET) for fifteen (8 female) clinically unclassifiable PPA patients. Median age of onset was 64 years old with median 3 years disease duration at exam. Three patients were amyloid positive on PiB-PET. 14/15 patients had abnormal FDG-PETs with left predominant hypometabolism, affecting frontal, temporal, parietal, and even occipital lobes. Patients had mild to severe clinical presentations. Visualization of the FDG-PETs principal component analysis revealed patterns of hypometabolism similar to those seen in the PPA variants and suggests the brain regions affected in unclassifiable PPA patients are no different from those who are more easily classifiable. These findings may inform future modifications to the diagnostic criteria to improve diagnostic classification.

Original languageEnglish (US)
Article number104676
JournalBrain and Language
Volume197
DOIs
StatePublished - Oct 1 2019

Fingerprint

Primary Progressive Aphasia
speech disorder
Neuroimaging
diagnostic
visualization
Occipital Lobe
brain
Principal Component Analysis
Disease
Age of Onset
Amyloid
Language
language
Brain

Keywords

  • Amyloid imaging
  • Frontotemporal dementia
  • Hypometabolism
  • PET imaging
  • Primary progressive aphasia

ASJC Scopus subject areas

  • Experimental and Cognitive Psychology
  • Language and Linguistics
  • Linguistics and Language
  • Cognitive Neuroscience
  • Speech and Hearing

Cite this

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title = "Clinical and neuroimaging characteristics of clinically unclassifiable primary progressive aphasia",
abstract = "Many patients who meet core/root criteria for Primary Progressive Aphasia (PPA) are not classifiable as a recognized variant and are often excluded from neuroimaging studies. Here, we detail neurological, neuropsychological, speech and language assessments, and anatomic and molecular neuroimaging (MRI, PiB-PET, and FDG-PET) for fifteen (8 female) clinically unclassifiable PPA patients. Median age of onset was 64 years old with median 3 years disease duration at exam. Three patients were amyloid positive on PiB-PET. 14/15 patients had abnormal FDG-PETs with left predominant hypometabolism, affecting frontal, temporal, parietal, and even occipital lobes. Patients had mild to severe clinical presentations. Visualization of the FDG-PETs principal component analysis revealed patterns of hypometabolism similar to those seen in the PPA variants and suggests the brain regions affected in unclassifiable PPA patients are no different from those who are more easily classifiable. These findings may inform future modifications to the diagnostic criteria to improve diagnostic classification.",
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author = "Rene Utianski and Hugo Botha and Martin, {Peter R.} and Christopher Schwarz and Duffy, {Joseph R.} and Heather Clark and Machulda, {Mary Margaret} and Alissa Butts and Val Lowe and Jack, {Clifford R Jr.} and Senjem, {Matthew L.} and Spychalla, {Anthony J.} and Whitwell, {Jennifer Lynn} and Josephs, {Keith Anthony}",
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AU - Botha, Hugo

AU - Martin, Peter R.

AU - Schwarz, Christopher

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AU - Clark, Heather

AU - Machulda, Mary Margaret

AU - Butts, Alissa

AU - Lowe, Val

AU - Jack, Clifford R Jr.

AU - Senjem, Matthew L.

AU - Spychalla, Anthony J.

AU - Whitwell, Jennifer Lynn

AU - Josephs, Keith Anthony

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