Clarity and caution in the natural history of low-grade dysplasia in ulcerative colitis

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A substantial body of evidence supports the safety of conservative endoscopic polypectomy for discrete, adenomatous-appearing colonic polyps in patients with ulcerative colitis (UC). Much less is known about the clinicopathologic factors of low-grade dysplastic lesions at risk for subsequent high-grade dysplasia or colorectal cancer. In this issue of the American Journal of Gastroenterology, Choi et al. examine the outcome of patients with low-grade dysplasia participating in a surveillance cohort at St Mark's Hospital, one of the oldest and largest programs of its kind. Long-term follow-up of many, well-phenotyped, low-grade dysplasia cases sheds new light, and raises new questions, on our UC surveillance practice.

Original languageEnglish (US)
Pages (from-to)1473-1474
Number of pages2
JournalThe American journal of gastroenterology
Issue number10
StatePublished - Oct 1 2015


ASJC Scopus subject areas

  • Medicine(all)

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