Circulating soluble ICAM-1 levels shows linkage to ICAM gene cluster region on chromosome 19: The NHLBI Family Heart Study follow-up examination

Suzette J. Bielinski, James S. Pankow, Catherine Leiendecker Foster, Michael B. Miller, Paul N. Hopkins, John H. Eckfeldt, Jim Hixson, Yongmei Liu, Tom Register, Richard H. Myers, Donna K. Arnett

Research output: Contribution to journalArticle

11 Scopus citations

Abstract

Atherogenesis is a chronic inflammatory process in which intercellular adhesion molecule 1 (ICAM-1) plays a critical role. Circulating soluble ICAM-1 (sICAM-1) is thought to be the result of cleavage of membrane-bound ICAM-1 and its concentration in serum/plasma has been shown to be heritable. Genome-wide linkage scans were conducted for quantitative trait loci influencing sICAM-1. Phenotype and genetic marker data were available for 2617 white and 531 black individuals in the NHLBI Family Heart Study follow-up examination. Heritability for sICAM-1 was 0.39 in whites and 0.59 in blacks. Significant linkage was observed on chromosome 19 (LOD = 4.0 at 14 cM) in whites near the ICAM gene cluster that includes the structural gene for ICAM-1. The T-allele of ICAM-1 SNP rs5491 has been strongly associated with the specific sICAM-1 assay we used in our study. Through additional genotyping we were able to rule out rs5491 as the cause of the linkage finding. This study provides preliminary evidence linking genetic variation in the ICAM1 structural gene to circulating sICAM-1 levels.

Original languageEnglish (US)
Pages (from-to)172-178
Number of pages7
JournalAtherosclerosis
Volume199
Issue number1
DOIs
StatePublished - Jul 1 2008

    Fingerprint

Keywords

  • Atherosclerosis
  • ICAM gene cluster
  • Inflammation
  • Intercellular adhesion molecule-1
  • Linkage (genetics)

ASJC Scopus subject areas

  • Cardiology and Cardiovascular Medicine

Cite this

Bielinski, S. J., Pankow, J. S., Foster, C. L., Miller, M. B., Hopkins, P. N., Eckfeldt, J. H., Hixson, J., Liu, Y., Register, T., Myers, R. H., & Arnett, D. K. (2008). Circulating soluble ICAM-1 levels shows linkage to ICAM gene cluster region on chromosome 19: The NHLBI Family Heart Study follow-up examination. Atherosclerosis, 199(1), 172-178. https://doi.org/10.1016/j.atherosclerosis.2007.10.006