Circulating osteogenic precursor cells

Robert J. Pignolo, Eileen M. Shore

Research output: Contribution to journalArticle

14 Scopus citations

Abstract

Circulating osteogenic precursor (COP) cells are blood-borne cells that express a variety of osteoblastic markers and are able to form bone in vivo. Strong evidence suggests that COP cells are derived from bone marrow and are of hematopoietic origin. The study of COP cells has been limited by several factors, including the difficulty in establishing long-term cultures and lack of a standardized protocol for their isolation and identification. However, experimental evidence supports that COP cells seed sites of injury and inflammation in response to homing signals and are involved in processes of pubertal growth, fracture, and diverse conditions of heterotopic bone formation. The role of COP cells in physiologic and pathophysiologic conditions of de novo bone formation suggests that they may serve as future targets for diagnostic measurements and therapeutic interventions.

Original languageEnglish (US)
Pages (from-to)171-180
Number of pages10
JournalCritical Reviews in Eukaryotic Gene Expression
Volume20
Issue number2
DOIs
StatePublished - Jan 1 2010

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Keywords

  • CXCR4
  • Circulating osteogenic precursor cells
  • Heterotopic ossification
  • Monocytes
  • SDF-1

ASJC Scopus subject areas

  • Molecular Biology
  • Genetics

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