Circulating cytokine concentrations are not associated with major depressive disorder in a community-based cohort

Gunnar Einvik, Maria Vistnes, Harald Hrubos-Strøm, Anna Randby, Silje K. Namtvedt, Inger H. Nordhus, Virend Somers, Toril Dammen, Torbjørn Omland

Research output: Contribution to journalArticle

18 Citations (Scopus)

Abstract

Objective: The objective was to test the hypotheses that cytokine levels are elevated in community-residing persons at high risk for obstructive sleep apnea with major depressive disorder (MDD) compared to nondepressive persons and that cytokine levels show stronger correlations with somatic than psychological symptoms of depression. Method: A case-control study within the cross-sectional Akershus Sleep Apnea Project was performed. Two controls matched for age, gender, metabolic syndrome and obstructive sleep apnea were drawn for each case of MDD. Results: Group comparisons revealed no significant difference in the levels of 17 cytokines [interleukin-1β, -2,-4, -5, -6, -7, -8, -10, -12(p70), -13 and -17; tumor necrosis factor-α; interferon-γ; granulocyte colony-stimulating factor; granulocyte-monocyte colony-stimulating factor; macrophage chemoattractant protein-1 and monocyte inhibitory protein-1β] between persons with (n=34) and without MDD (n=68). There was no association between cytokines levels and MDD in multivariate regression analyses. The concentration of interleukin-4 was significantly more positively correlated with psychological than somatic symptoms (r=0.046 vs. -0.143, respectively, P=0.024), while no different correlations were observed for other cytokines. Conclusion: The cytokine levels were not elevated in MDD, and cytokine levels were not more strongly associated with somatic than psychological symptoms of depression. The depression-specific effect on inflammation may be weak in community-based samples with prevalent somatic comorbidity.

Original languageEnglish (US)
Pages (from-to)262-267
Number of pages6
JournalGeneral Hospital Psychiatry
Volume34
Issue number3
DOIs
StatePublished - May 2012

Fingerprint

Major Depressive Disorder
Cytokines
Obstructive Sleep Apnea
Granulocyte Colony-Stimulating Factor
Depression
Psychology
Chemokine CCL2
Sleep Apnea Syndromes
Interleukin-1
Interleukin-4
Interferons
Interleukin-2
Case-Control Studies
Comorbidity
Monocytes
Multivariate Analysis
Tumor Necrosis Factor-alpha
Macrophages
Regression Analysis
Inflammation

Keywords

  • Beck Depression Inventory
  • Cytokines
  • Inflammation
  • Major depressive disorder
  • Obstructive sleep apnea

ASJC Scopus subject areas

  • Psychiatry and Mental health

Cite this

Einvik, G., Vistnes, M., Hrubos-Strøm, H., Randby, A., Namtvedt, S. K., Nordhus, I. H., ... Omland, T. (2012). Circulating cytokine concentrations are not associated with major depressive disorder in a community-based cohort. General Hospital Psychiatry, 34(3), 262-267. https://doi.org/10.1016/j.genhosppsych.2012.01.017

Circulating cytokine concentrations are not associated with major depressive disorder in a community-based cohort. / Einvik, Gunnar; Vistnes, Maria; Hrubos-Strøm, Harald; Randby, Anna; Namtvedt, Silje K.; Nordhus, Inger H.; Somers, Virend; Dammen, Toril; Omland, Torbjørn.

In: General Hospital Psychiatry, Vol. 34, No. 3, 05.2012, p. 262-267.

Research output: Contribution to journalArticle

Einvik, G, Vistnes, M, Hrubos-Strøm, H, Randby, A, Namtvedt, SK, Nordhus, IH, Somers, V, Dammen, T & Omland, T 2012, 'Circulating cytokine concentrations are not associated with major depressive disorder in a community-based cohort', General Hospital Psychiatry, vol. 34, no. 3, pp. 262-267. https://doi.org/10.1016/j.genhosppsych.2012.01.017
Einvik, Gunnar ; Vistnes, Maria ; Hrubos-Strøm, Harald ; Randby, Anna ; Namtvedt, Silje K. ; Nordhus, Inger H. ; Somers, Virend ; Dammen, Toril ; Omland, Torbjørn. / Circulating cytokine concentrations are not associated with major depressive disorder in a community-based cohort. In: General Hospital Psychiatry. 2012 ; Vol. 34, No. 3. pp. 262-267.
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