TY - JOUR
T1 - Churg-Strauss syndrome
AU - Ramakrishna, G.
AU - Midthun, D. E.
N1 - Funding Information:
Supported by a grant from AstraZeneca Pharmaceuticals
PY - 2001
Y1 - 2001
N2 - Objectives: This article discusses the clinical manifestations and treatment protocols of Churg-Strauss syndrome (CSS). A review of the definition, pathophysiology, and prognosis of CSS is included, as well as more recent evidence of the presumed association between antileukotriene antagonists and CSS. Data sources: Relevant articles in the medical literature derived from searching the MEDLINE database (1966 to present) with key terms Churg-Strauss syndrome, allergic granulomatosis, and allergic granulomatous angiitis. Sources included review articles, meta-analyses, randomized control trials, case reports, case series, and seminal articles, the majority of which had been published within the past decade. Study selection: Studies that described the clinical manifestations, pathophysiology, etiology, treatment, or prognosis of CSS. Results: CSS is a systemic vasculitic disorder with multiorgan involvement and diverse presentations. Conclusions: Recognition of the multiorgan manifestations of CSS is crucial to clinical management. Whether a causal relationship exists between antileukotriene antagonists and onset of CSS remains unclear.
AB - Objectives: This article discusses the clinical manifestations and treatment protocols of Churg-Strauss syndrome (CSS). A review of the definition, pathophysiology, and prognosis of CSS is included, as well as more recent evidence of the presumed association between antileukotriene antagonists and CSS. Data sources: Relevant articles in the medical literature derived from searching the MEDLINE database (1966 to present) with key terms Churg-Strauss syndrome, allergic granulomatosis, and allergic granulomatous angiitis. Sources included review articles, meta-analyses, randomized control trials, case reports, case series, and seminal articles, the majority of which had been published within the past decade. Study selection: Studies that described the clinical manifestations, pathophysiology, etiology, treatment, or prognosis of CSS. Results: CSS is a systemic vasculitic disorder with multiorgan involvement and diverse presentations. Conclusions: Recognition of the multiorgan manifestations of CSS is crucial to clinical management. Whether a causal relationship exists between antileukotriene antagonists and onset of CSS remains unclear.
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U2 - 10.1016/S1081-1206(10)62286-7
DO - 10.1016/S1081-1206(10)62286-7
M3 - Review article
C2 - 11428732
AN - SCOPUS:0034979079
SN - 1081-1206
VL - 86
SP - 603
EP - 613
JO - Annals of Allergy, Asthma and Immunology
JF - Annals of Allergy, Asthma and Immunology
IS - 6
ER -