Chronic traumatic encephalopathy in an epilepsy surgery cohort

Amy L. Jones, Jeffrey W. Britton, Melissa M. Blessing, Joseph E Parisi, Gregory D Cascino

Research output: Contribution to journalArticle

2 Citations (Scopus)

Abstract

Objective To determine the occurrence of chronic traumatic encephalopathy (CTE) in young adult patients undergoing epilepsy surgery. Methods Ten patients who underwent epilepsy surgery were randomly selected for this retrospective study. The patients were 18-45 years of age, had preoperative neuropsychological evaluation, and had 1 year postoperative follow-up. Microscopic sections from resections were evaluated for the presence of CTE with standard stains and antibodies to tau (clone AT8). Results The median age at resection was 32.5 years (range 23-43) and the median duration of seizures was 23.5 years (range 3-28). Eight had a history of head injury. Preoperative neuropsychological testing showed mild to moderate cognitive impairment in 8 patients (80%). Pathologic examination in one patient showed focal sparse tau-immunoreactive lesions along descending rami and cortical gyral depths of the resected frontal lobe. Nine patients had no evidence of CTE. All focal cortical resections showed variable subpial and subcortical gliosis commonly identified in patients with chronic seizure disorders. Conclusions The present small retrospective observational study suggests that CTE may occur, but appears uncommon, in young adult patients undergoing surgical treatment for drug-resistant focal epilepsy. The significance of these findings requires further investigation to define the relative importance of tau accumulation in younger adult patients with drug-resistant focal epilepsy and cognitive decline.

Original languageEnglish (US)
Pages (from-to)e474-e478
JournalNeurology
Volume90
Issue number6
DOIs
StatePublished - Feb 6 2018

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Epilepsy
Young Adult
Partial Epilepsy
Retrospective Studies
Chronic Traumatic Encephalopathy
Gliosis
Frontal Lobe
Craniocerebral Trauma
Observational Studies
Seizures
Coloring Agents
Clone Cells
Antibodies

ASJC Scopus subject areas

  • Clinical Neurology

Cite this

Jones, A. L., Britton, J. W., Blessing, M. M., Parisi, J. E., & Cascino, G. D. (2018). Chronic traumatic encephalopathy in an epilepsy surgery cohort. Neurology, 90(6), e474-e478. https://doi.org/10.1212/WNL.0000000000004927

Chronic traumatic encephalopathy in an epilepsy surgery cohort. / Jones, Amy L.; Britton, Jeffrey W.; Blessing, Melissa M.; Parisi, Joseph E; Cascino, Gregory D.

In: Neurology, Vol. 90, No. 6, 06.02.2018, p. e474-e478.

Research output: Contribution to journalArticle

Jones, AL, Britton, JW, Blessing, MM, Parisi, JE & Cascino, GD 2018, 'Chronic traumatic encephalopathy in an epilepsy surgery cohort', Neurology, vol. 90, no. 6, pp. e474-e478. https://doi.org/10.1212/WNL.0000000000004927
Jones, Amy L. ; Britton, Jeffrey W. ; Blessing, Melissa M. ; Parisi, Joseph E ; Cascino, Gregory D. / Chronic traumatic encephalopathy in an epilepsy surgery cohort. In: Neurology. 2018 ; Vol. 90, No. 6. pp. e474-e478.
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