TY - JOUR
T1 - Chronic pancreatitis
AU - Majumder, Shounak
AU - Chari, Suresh T.
N1 - Publisher Copyright:
© 2016 Elsevier Ltd.
PY - 2016/5/7
Y1 - 2016/5/7
N2 - Chronic pancreatitis describes a wide spectrum of fibro-inflammatory disorders of the exocrine pancreas that includes calcifying, obstructive, and steroid-responsive forms. Use of the term chronic pancreatitis without qualification generally refers to calcifying chronic pancreatitis. Epidemiology is poorly defined, but incidence worldwide seems to be on the rise. Smoking, drinking alcohol, and genetic predisposition are the major risk factors for chronic calcifying pancreatitis. In this Seminar, we discuss the clinical features, diagnosis, and management of chronic calcifying pancreatitis, focusing on pain management, the role of endoscopic and surgical intervention, and the use of pancreatic enzyme-replacement therapy. Management of patients is often challenging and necessitates a multidisciplinary approach.
AB - Chronic pancreatitis describes a wide spectrum of fibro-inflammatory disorders of the exocrine pancreas that includes calcifying, obstructive, and steroid-responsive forms. Use of the term chronic pancreatitis without qualification generally refers to calcifying chronic pancreatitis. Epidemiology is poorly defined, but incidence worldwide seems to be on the rise. Smoking, drinking alcohol, and genetic predisposition are the major risk factors for chronic calcifying pancreatitis. In this Seminar, we discuss the clinical features, diagnosis, and management of chronic calcifying pancreatitis, focusing on pain management, the role of endoscopic and surgical intervention, and the use of pancreatic enzyme-replacement therapy. Management of patients is often challenging and necessitates a multidisciplinary approach.
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U2 - 10.1016/S0140-6736(16)00097-0
DO - 10.1016/S0140-6736(16)00097-0
M3 - Review article
C2 - 26948434
AN - SCOPUS:84961219353
SN - 0140-6736
VL - 387
SP - 1957
EP - 1966
JO - The Lancet
JF - The Lancet
IS - 10031
ER -