Chronic obstructive pulmonary disease and association with mild cognitive impairment: The Mayo Clinic Study of Aging

Balwinder Singh, Ajay K. Parsaik, Michelle M Mielke, Rosebud O Roberts, Paul D Scanlon, Yonas Endale Geda, V. Shane Pankratz, Teresa Christianson, Barbara P. Yawn, Ronald Carl Petersen

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Abstract

Objective: To investigate the association of chronic obstructive pulmonary disease (COPD) with mild cognitive impairment (MCI) and MCI subtype: amnestic MCI and nonamnestic MCI, in a populationbased study of elderly patients. Patients and Methods: Participants included 1927 individuals aged 70 to 89 years enrolled in the population-based Mayo Clinic Study of Aging. Participants were evaluated by using a nurse assessment, neurological evaluation, and neuropsychological testing, and the diagnosis of MCI was made by a consensus panel according to the standardized criteria. Chronic obstructive pulmonary disease was identified by the review of medical records. The study was conducted from October 1, 2004, through July 31, 2007. The associations of COPD and disease duration with MCI and its subtypes were evaluated by using logistic regression models adjusted for potential covariates. Results: Of 1927 participants, 288 had COPD (men vs women: 18% vs 12%; P<.001). As compared with patients without COPD, patients with COPD had a higher prevalence of MCI (27% vs 15%; P<.001). The odds ratio (OR) for MCI was almost 2 times higher in patients with COPD than in those without (OR, 1.87; 95% CI, 1.34-2.61), with a similar effect in men and women. The OR for MCI increased from 1.60 (95% CI, 0.97-2.57) in patients with a COPD duration of 5 years or less to 2.10 (95% CI, 1.38-3.14) in patients with a COPD duration of more than 5 years. Conclusion: This population-based study suggests that COPD is associated with increased odds of having MCI and its subtypes. There was a dose-response relationship with the duration of COPD after controlling for the potential covariates.

Original languageEnglish (US)
Pages (from-to)1222-1230
Number of pages9
JournalMayo Clinic Proceedings
Volume88
Issue number11
DOIs
StatePublished - 2013

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Chronic Obstructive Pulmonary Disease
Odds Ratio
Cognitive Dysfunction
Logistic Models
Population
Medical Records
Consensus
Nurses

ASJC Scopus subject areas

  • Medicine(all)

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Chronic obstructive pulmonary disease and association with mild cognitive impairment : The Mayo Clinic Study of Aging. / Singh, Balwinder; Parsaik, Ajay K.; Mielke, Michelle M; Roberts, Rosebud O; Scanlon, Paul D; Geda, Yonas Endale; Pankratz, V. Shane; Christianson, Teresa; Yawn, Barbara P.; Petersen, Ronald Carl.

In: Mayo Clinic Proceedings, Vol. 88, No. 11, 2013, p. 1222-1230.

Research output: Contribution to journalArticle

Singh, Balwinder ; Parsaik, Ajay K. ; Mielke, Michelle M ; Roberts, Rosebud O ; Scanlon, Paul D ; Geda, Yonas Endale ; Pankratz, V. Shane ; Christianson, Teresa ; Yawn, Barbara P. ; Petersen, Ronald Carl. / Chronic obstructive pulmonary disease and association with mild cognitive impairment : The Mayo Clinic Study of Aging. In: Mayo Clinic Proceedings. 2013 ; Vol. 88, No. 11. pp. 1222-1230.
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abstract = "Objective: To investigate the association of chronic obstructive pulmonary disease (COPD) with mild cognitive impairment (MCI) and MCI subtype: amnestic MCI and nonamnestic MCI, in a populationbased study of elderly patients. Patients and Methods: Participants included 1927 individuals aged 70 to 89 years enrolled in the population-based Mayo Clinic Study of Aging. Participants were evaluated by using a nurse assessment, neurological evaluation, and neuropsychological testing, and the diagnosis of MCI was made by a consensus panel according to the standardized criteria. Chronic obstructive pulmonary disease was identified by the review of medical records. The study was conducted from October 1, 2004, through July 31, 2007. The associations of COPD and disease duration with MCI and its subtypes were evaluated by using logistic regression models adjusted for potential covariates. Results: Of 1927 participants, 288 had COPD (men vs women: 18{\%} vs 12{\%}; P<.001). As compared with patients without COPD, patients with COPD had a higher prevalence of MCI (27{\%} vs 15{\%}; P<.001). The odds ratio (OR) for MCI was almost 2 times higher in patients with COPD than in those without (OR, 1.87; 95{\%} CI, 1.34-2.61), with a similar effect in men and women. The OR for MCI increased from 1.60 (95{\%} CI, 0.97-2.57) in patients with a COPD duration of 5 years or less to 2.10 (95{\%} CI, 1.38-3.14) in patients with a COPD duration of more than 5 years. Conclusion: This population-based study suggests that COPD is associated with increased odds of having MCI and its subtypes. There was a dose-response relationship with the duration of COPD after controlling for the potential covariates.",
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AU - Singh, Balwinder

AU - Parsaik, Ajay K.

AU - Mielke, Michelle M

AU - Roberts, Rosebud O

AU - Scanlon, Paul D

AU - Geda, Yonas Endale

AU - Pankratz, V. Shane

AU - Christianson, Teresa

AU - Yawn, Barbara P.

AU - Petersen, Ronald Carl

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N2 - Objective: To investigate the association of chronic obstructive pulmonary disease (COPD) with mild cognitive impairment (MCI) and MCI subtype: amnestic MCI and nonamnestic MCI, in a populationbased study of elderly patients. Patients and Methods: Participants included 1927 individuals aged 70 to 89 years enrolled in the population-based Mayo Clinic Study of Aging. Participants were evaluated by using a nurse assessment, neurological evaluation, and neuropsychological testing, and the diagnosis of MCI was made by a consensus panel according to the standardized criteria. Chronic obstructive pulmonary disease was identified by the review of medical records. The study was conducted from October 1, 2004, through July 31, 2007. The associations of COPD and disease duration with MCI and its subtypes were evaluated by using logistic regression models adjusted for potential covariates. Results: Of 1927 participants, 288 had COPD (men vs women: 18% vs 12%; P<.001). As compared with patients without COPD, patients with COPD had a higher prevalence of MCI (27% vs 15%; P<.001). The odds ratio (OR) for MCI was almost 2 times higher in patients with COPD than in those without (OR, 1.87; 95% CI, 1.34-2.61), with a similar effect in men and women. The OR for MCI increased from 1.60 (95% CI, 0.97-2.57) in patients with a COPD duration of 5 years or less to 2.10 (95% CI, 1.38-3.14) in patients with a COPD duration of more than 5 years. Conclusion: This population-based study suggests that COPD is associated with increased odds of having MCI and its subtypes. There was a dose-response relationship with the duration of COPD after controlling for the potential covariates.

AB - Objective: To investigate the association of chronic obstructive pulmonary disease (COPD) with mild cognitive impairment (MCI) and MCI subtype: amnestic MCI and nonamnestic MCI, in a populationbased study of elderly patients. Patients and Methods: Participants included 1927 individuals aged 70 to 89 years enrolled in the population-based Mayo Clinic Study of Aging. Participants were evaluated by using a nurse assessment, neurological evaluation, and neuropsychological testing, and the diagnosis of MCI was made by a consensus panel according to the standardized criteria. Chronic obstructive pulmonary disease was identified by the review of medical records. The study was conducted from October 1, 2004, through July 31, 2007. The associations of COPD and disease duration with MCI and its subtypes were evaluated by using logistic regression models adjusted for potential covariates. Results: Of 1927 participants, 288 had COPD (men vs women: 18% vs 12%; P<.001). As compared with patients without COPD, patients with COPD had a higher prevalence of MCI (27% vs 15%; P<.001). The odds ratio (OR) for MCI was almost 2 times higher in patients with COPD than in those without (OR, 1.87; 95% CI, 1.34-2.61), with a similar effect in men and women. The OR for MCI increased from 1.60 (95% CI, 0.97-2.57) in patients with a COPD duration of 5 years or less to 2.10 (95% CI, 1.38-3.14) in patients with a COPD duration of more than 5 years. Conclusion: This population-based study suggests that COPD is associated with increased odds of having MCI and its subtypes. There was a dose-response relationship with the duration of COPD after controlling for the potential covariates.

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