TY - JOUR
T1 - Chronic obstructive pulmonary disease and association with mild cognitive impairment
T2 - The Mayo Clinic Study of Aging
AU - Singh, Balwinder
AU - Parsaik, Ajay K.
AU - Mielke, Michelle M.
AU - Roberts, Rosebud O.
AU - Scanlon, Paul D.
AU - Geda, Yonas E.
AU - Pankratz, V. Shane
AU - Christianson, Teresa
AU - Yawn, Barbara P.
AU - Petersen, Ronald C.
N1 - Funding Information:
Grant Support: This work was supported by National Institutes of Health (NIH) grants P50 AG016574 , U01 AG006786 , K01 MH068351 , and K01 AG028573 ; by the Robert Wood Johnson Foundation ; by the Robert H. and Clarice Smith and Abigail van Buren Alzheimer's Disease Research Program; by Clinical and Translational Science Award UL1 TR000135 from the National Center for Advancing Translational Sciences , a component of the NIH; and by the Rochester Epidemiology Project (grant number R01-AG034676 ; Principal Investigators: Walter A. Rocca, MD, MPH, and Barbara P. Yawn, MD, MSc). Its contents are solely the responsibility of the authors and do not necessarily represent the official view of the NIH.
Funding Information:
Potential Competing Interests: Dr Mielke has received funding from the National Institute on Aging and the Alzheimer Drug Discovery Foundation . Dr Roberts has received research support from the National Institutes of Health and the Driskill Foundation . Dr Yawn has received funding from BI, Merck, and Forrest related to COPD, but no funding related to COPD and cognitive issues. Dr Petersen serves on scientific advisory boards for the Alzheimer's Association, the National Advisory Council on Aging, Elan/Janssen AI, Pfizer Inc (Wyeth), and GE Healthcare; receives publishing royalties from Mild Cognitive Impairment (Oxford University Press, 2003); serves as a consultant to Elan/Janssen AI and GE Healthcare; and has received research support from the National Institutes of Health/National Advisory Council on Aging .
PY - 2013/11
Y1 - 2013/11
N2 - Objective: To investigate the association of chronic obstructive pulmonary disease (COPD) with mild cognitive impairment (MCI) and MCI subtype: amnestic MCI and nonamnestic MCI, in a populationbased study of elderly patients. Patients and Methods: Participants included 1927 individuals aged 70 to 89 years enrolled in the population-based Mayo Clinic Study of Aging. Participants were evaluated by using a nurse assessment, neurological evaluation, and neuropsychological testing, and the diagnosis of MCI was made by a consensus panel according to the standardized criteria. Chronic obstructive pulmonary disease was identified by the review of medical records. The study was conducted from October 1, 2004, through July 31, 2007. The associations of COPD and disease duration with MCI and its subtypes were evaluated by using logistic regression models adjusted for potential covariates. Results: Of 1927 participants, 288 had COPD (men vs women: 18% vs 12%; P<.001). As compared with patients without COPD, patients with COPD had a higher prevalence of MCI (27% vs 15%; P<.001). The odds ratio (OR) for MCI was almost 2 times higher in patients with COPD than in those without (OR, 1.87; 95% CI, 1.34-2.61), with a similar effect in men and women. The OR for MCI increased from 1.60 (95% CI, 0.97-2.57) in patients with a COPD duration of 5 years or less to 2.10 (95% CI, 1.38-3.14) in patients with a COPD duration of more than 5 years. Conclusion: This population-based study suggests that COPD is associated with increased odds of having MCI and its subtypes. There was a dose-response relationship with the duration of COPD after controlling for the potential covariates.
AB - Objective: To investigate the association of chronic obstructive pulmonary disease (COPD) with mild cognitive impairment (MCI) and MCI subtype: amnestic MCI and nonamnestic MCI, in a populationbased study of elderly patients. Patients and Methods: Participants included 1927 individuals aged 70 to 89 years enrolled in the population-based Mayo Clinic Study of Aging. Participants were evaluated by using a nurse assessment, neurological evaluation, and neuropsychological testing, and the diagnosis of MCI was made by a consensus panel according to the standardized criteria. Chronic obstructive pulmonary disease was identified by the review of medical records. The study was conducted from October 1, 2004, through July 31, 2007. The associations of COPD and disease duration with MCI and its subtypes were evaluated by using logistic regression models adjusted for potential covariates. Results: Of 1927 participants, 288 had COPD (men vs women: 18% vs 12%; P<.001). As compared with patients without COPD, patients with COPD had a higher prevalence of MCI (27% vs 15%; P<.001). The odds ratio (OR) for MCI was almost 2 times higher in patients with COPD than in those without (OR, 1.87; 95% CI, 1.34-2.61), with a similar effect in men and women. The OR for MCI increased from 1.60 (95% CI, 0.97-2.57) in patients with a COPD duration of 5 years or less to 2.10 (95% CI, 1.38-3.14) in patients with a COPD duration of more than 5 years. Conclusion: This population-based study suggests that COPD is associated with increased odds of having MCI and its subtypes. There was a dose-response relationship with the duration of COPD after controlling for the potential covariates.
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U2 - 10.1016/j.mayocp.2013.08.012
DO - 10.1016/j.mayocp.2013.08.012
M3 - Article
C2 - 24182702
AN - SCOPUS:84888868685
SN - 0025-6196
VL - 88
SP - 1222
EP - 1230
JO - Mayo Clinic proceedings
JF - Mayo Clinic proceedings
IS - 11
ER -