Chronic natural killer cell lymphocytosis

Research output: Contribution to journalArticle

23 Citations (Scopus)

Abstract

Chronic proliferations of natural killer (NK) cells (CD3- CD16+) are identified initially by detecting large granular lymphocyte (LGL) excess in a peripheral blood smear and subsequent lymphocyte immunophenotyping by flow cytometry. A related disease, T-LGL leukemia, has an indolent clinical course with chronic neutropenia and a close association with rheumatoid arthritis. Herein are described the clinical presentation and long-term clinical course of patients with chronic NK cell lymphocytosis (CNKL). The majority of the 14 patients followed up for a median of 4 years presented with severe cytopenias or vasculitic syndromes that were responsive to immunosuppressive therapy. Other manifestations included fever and arthralgias. In general, the disease was nonprogressive and had a course similar to that of T-LGL leukemia.

Original languageEnglish (US)
Pages (from-to)245-248
Number of pages4
JournalLeukemia and Lymphoma
Volume20
Issue number3-4
StatePublished - 1996

Fingerprint

Large Granular Lymphocytic Leukemia
Lymphocytosis
Natural Killer Cells
Immunophenotyping
Arthralgia
Immunosuppressive Agents
Neutropenia
Rheumatoid Arthritis
Flow Cytometry
Fever
Lymphocytes
Therapeutics

Keywords

  • Cytopenia
  • Immunosuppression
  • Leukemia
  • Natural killer cells
  • Peripheral blood smear
  • Vasculitic syndrome

ASJC Scopus subject areas

  • Cancer Research
  • Hematology
  • Oncology

Cite this

Chronic natural killer cell lymphocytosis. / Tefferi, Ayalew.

In: Leukemia and Lymphoma, Vol. 20, No. 3-4, 1996, p. 245-248.

Research output: Contribution to journalArticle

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