Chronic Myelomonocytic Leukemia: Natural History and Prognostic Determinants

AYALEW TEFFERI, H. CLARK HOAGLAND, TERRY M. THERNEAU, ROBERT V. PIERRE

Research output: Contribution to journalArticle

57 Scopus citations

Abstract

A retrospective clinical review of 41 patients with chronic myelomonocytic leukemia revealed a median age of 66 years and a male:female ratio of 2.4:1. The disease was preceded by a myelodysplastic syndrome of a different subtype in 24% of the patients and transformed into acute leukemia in 24%. Splenomegaly was present in 54% of the patients and reached massive proportions in 24%. Chromosomal abnormalities occurred in 34% of those studied, most commonly in the younger age group; the most frequent were trisomy 8, monosomy 7, and deletions involving the long arms of chromosomes 20 and X. Polyclonal hypergammaglobulinemia was detected in 47% of the patients in whom serum protein electrophoresis was done. The median survival was 3 years. With use of univariate analysis, the statistically significant prognostic determinants were hemoglobin level, the “modified Bournemouth score,” and bone marrow blast cell percentage. When these factors were subjected to a multivariate analysis, only bone marrow blast cell percentage was an independent prognostic determinant. Orally administered hydroxyurea controlled leukocytosis and splenomegaly in some patients without affecting the overall prognosis.

Original languageEnglish (US)
Pages (from-to)1246-1254
Number of pages9
JournalMayo Clinic proceedings
Volume64
Issue number10
DOIs
StatePublished - Jan 1 1989

ASJC Scopus subject areas

  • Medicine(all)

Fingerprint Dive into the research topics of 'Chronic Myelomonocytic Leukemia: Natural History and Prognostic Determinants'. Together they form a unique fingerprint.

  • Cite this