Chromosome missegregation causes colon cancer by APC loss of heterozygosity

Research output: Contribution to journalArticle

26 Citations (Scopus)

Abstract

A longstanding hypothesis in the field of cancer biology is that aneuploidy causes cancer by promoting loss of chromosomes that contain tumor suppressor genes. By crossing aneuploidyprone Bub1 hypomorphic mice onto a heterozygous null background for p53, we provided conclusive evidence for this idea.1 Surprisingly, the tumors that developed in this model had not just lost the chromosome 11 copy harboring wildtype p53, but had also gained an extra copy of chromosome 11 bearing the p53 null allele. Here we report that a similar chromosome-reshuffling blueprint drives colonic tumorigenesis in Bub1 hypomorphic mice that are heterozygous for ApcMin, but now involving chromosome 18. These extended studies highlight that in order for whole chromosome instability to drive tumorigenesis, it needs to establish tumor suppressor gene loss of heterozygosity while retaining two copies of the other genes on the chromosome. Additional restrictions seem to apply to whole chromosome instability as a cancer causing mechanism, which will be discussed in this paper.

Original languageEnglish (US)
Pages (from-to)1711-1716
Number of pages6
JournalCell Cycle
Volume9
Issue number9
DOIs
StatePublished - May 1 2010

Fingerprint

Loss of Heterozygosity
Colonic Neoplasms
Chromosomes
Chromosomal Instability
Chromosomes, Human, Pair 11
Tumor Suppressor Genes
Neoplasms
Carcinogenesis
Chromosomes, Human, Pair 18
Aneuploidy
Alleles
Genes

Keywords

  • Aneuploidy
  • Apc
  • Bub1
  • Colon cancer
  • Loss of heterozygosity
  • Mitotic checkpoint

ASJC Scopus subject areas

  • Cell Biology
  • Developmental Biology
  • Molecular Biology

Cite this

Chromosome missegregation causes colon cancer by APC loss of heterozygosity. / Baker, Darren J; Van Deursen, Jan.

In: Cell Cycle, Vol. 9, No. 9, 01.05.2010, p. 1711-1716.

Research output: Contribution to journalArticle

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