Abstract
Background. During primary infection, human herpesvirus-6 (HHV-6) may become integrated into the chromosome. This entity, termed chromosomally integrated HHV-6 (CIHHV-6), is often mistaken as active infection and treated unnecessarily. The prevalence of CIHHV-6 in kidney transplant recipients is not known.Methods. We performed quantitative HHV-6 polymerase chain reaction assay on whole blood samples collected from 47 kidney recipients. CIHHV-6 was defined as HHV-6 DNA levels >1 × 106 genomes/mL.Results. One of 47 kidney recipients was found to have CIHHV-6. The prevalence of CIHHV-6 was calculated at 2.1% (95% confidence interval, <0.01-12.1%). Despite an increase in HHV-6 DNA level after transplant, the patient did not develop clinical HHV-6 disease.Conclusions. CIHHV-6 may be observed in kidney transplant recipients. Clinicians should be aware of this entity so as not to provide unnecessary treatment to asymptomatic patients with CIHHV-6.
| Original language | English (US) |
|---|---|
| Pages (from-to) | 2391-2393 |
| Number of pages | 3 |
| Journal | Nephrology Dialysis Transplantation |
| Volume | 26 |
| Issue number | 7 |
| DOIs | |
| State | Published - Jul 2011 |
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Keywords
- chromosomal integration
- human herpesvirus-6
- infection
- kidney transplantation
- prevalence
ASJC Scopus subject areas
- Nephrology
- Transplantation
Cite this
Chromosomally integrated human herpesvirus-6 in kidney transplant recipients. / Lee, Sang Oh; Brown, Robert A.; Eid, Albert J.; Razonable, Raymund R.
In: Nephrology Dialysis Transplantation, Vol. 26, No. 7, 07.2011, p. 2391-2393.Research output: Contribution to journal › Article
}
TY - JOUR
T1 - Chromosomally integrated human herpesvirus-6 in kidney transplant recipients
AU - Lee, Sang Oh
AU - Brown, Robert A.
AU - Eid, Albert J.
AU - Razonable, Raymund R
PY - 2011/7
Y1 - 2011/7
N2 - Background. During primary infection, human herpesvirus-6 (HHV-6) may become integrated into the chromosome. This entity, termed chromosomally integrated HHV-6 (CIHHV-6), is often mistaken as active infection and treated unnecessarily. The prevalence of CIHHV-6 in kidney transplant recipients is not known.Methods. We performed quantitative HHV-6 polymerase chain reaction assay on whole blood samples collected from 47 kidney recipients. CIHHV-6 was defined as HHV-6 DNA levels >1 × 106 genomes/mL.Results. One of 47 kidney recipients was found to have CIHHV-6. The prevalence of CIHHV-6 was calculated at 2.1% (95% confidence interval, <0.01-12.1%). Despite an increase in HHV-6 DNA level after transplant, the patient did not develop clinical HHV-6 disease.Conclusions. CIHHV-6 may be observed in kidney transplant recipients. Clinicians should be aware of this entity so as not to provide unnecessary treatment to asymptomatic patients with CIHHV-6.
AB - Background. During primary infection, human herpesvirus-6 (HHV-6) may become integrated into the chromosome. This entity, termed chromosomally integrated HHV-6 (CIHHV-6), is often mistaken as active infection and treated unnecessarily. The prevalence of CIHHV-6 in kidney transplant recipients is not known.Methods. We performed quantitative HHV-6 polymerase chain reaction assay on whole blood samples collected from 47 kidney recipients. CIHHV-6 was defined as HHV-6 DNA levels >1 × 106 genomes/mL.Results. One of 47 kidney recipients was found to have CIHHV-6. The prevalence of CIHHV-6 was calculated at 2.1% (95% confidence interval, <0.01-12.1%). Despite an increase in HHV-6 DNA level after transplant, the patient did not develop clinical HHV-6 disease.Conclusions. CIHHV-6 may be observed in kidney transplant recipients. Clinicians should be aware of this entity so as not to provide unnecessary treatment to asymptomatic patients with CIHHV-6.
KW - chromosomal integration
KW - human herpesvirus-6
KW - infection
KW - kidney transplantation
KW - prevalence
UR - http://www.scopus.com/inward/record.url?scp=79959978537&partnerID=8YFLogxK
UR - http://www.scopus.com/inward/citedby.url?scp=79959978537&partnerID=8YFLogxK
U2 - 10.1093/ndt/gfr259
DO - 10.1093/ndt/gfr259
M3 - Article
C2 - 21565944
AN - SCOPUS:79959978537
VL - 26
SP - 2391
EP - 2393
JO - Nephrology Dialysis Transplantation
JF - Nephrology Dialysis Transplantation
SN - 0931-0509
IS - 7
ER -