Chromosomally integrated human herpesvirus-6 in kidney transplant recipients

Sang Oh Lee; Robert A. Brown; Albert J. Eid; Raymund R. Razonable

doi:10.1093/ndt/gfr259

Chromosomally integrated human herpesvirus-6 in kidney transplant recipients

Sang Oh Lee, Robert A. Brown, Albert J. Eid, Raymund R. Razonable

Infectious Diseases

Research output: Contribution to journal › Article › peer-review

19 Scopus citations

Abstract

Background. During primary infection, human herpesvirus-6 (HHV-6) may become integrated into the chromosome. This entity, termed chromosomally integrated HHV-6 (CIHHV-6), is often mistaken as active infection and treated unnecessarily. The prevalence of CIHHV-6 in kidney transplant recipients is not known.Methods. We performed quantitative HHV-6 polymerase chain reaction assay on whole blood samples collected from 47 kidney recipients. CIHHV-6 was defined as HHV-6 DNA levels >1 × 10⁶ genomes/mL.Results. One of 47 kidney recipients was found to have CIHHV-6. The prevalence of CIHHV-6 was calculated at 2.1% (95% confidence interval, <0.01-12.1%). Despite an increase in HHV-6 DNA level after transplant, the patient did not develop clinical HHV-6 disease.Conclusions. CIHHV-6 may be observed in kidney transplant recipients. Clinicians should be aware of this entity so as not to provide unnecessary treatment to asymptomatic patients with CIHHV-6.

Original language	English (US)
Pages (from-to)	2391-2393
Number of pages	3
Journal	Nephrology Dialysis Transplantation
Volume	26
Issue number	7
DOIs	https://doi.org/10.1093/ndt/gfr259
State	Published - Jul 2011

Keywords

chromosomal integration
human herpesvirus-6
infection
kidney transplantation
prevalence

ASJC Scopus subject areas

Nephrology
Transplantation

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10.1093/ndt/gfr259

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title = "Chromosomally integrated human herpesvirus-6 in kidney transplant recipients",

abstract = "Background. During primary infection, human herpesvirus-6 (HHV-6) may become integrated into the chromosome. This entity, termed chromosomally integrated HHV-6 (CIHHV-6), is often mistaken as active infection and treated unnecessarily. The prevalence of CIHHV-6 in kidney transplant recipients is not known.Methods. We performed quantitative HHV-6 polymerase chain reaction assay on whole blood samples collected from 47 kidney recipients. CIHHV-6 was defined as HHV-6 DNA levels >1 × 106 genomes/mL.Results. One of 47 kidney recipients was found to have CIHHV-6. The prevalence of CIHHV-6 was calculated at 2.1% (95% confidence interval, <0.01-12.1%). Despite an increase in HHV-6 DNA level after transplant, the patient did not develop clinical HHV-6 disease.Conclusions. CIHHV-6 may be observed in kidney transplant recipients. Clinicians should be aware of this entity so as not to provide unnecessary treatment to asymptomatic patients with CIHHV-6.",

keywords = "chromosomal integration, human herpesvirus-6, infection, kidney transplantation, prevalence",

author = "Lee, {Sang Oh} and Brown, {Robert A.} and Eid, {Albert J.} and Razonable, {Raymund R.}",

note = "Funding Information: Acknowledgements. We thank Teresa Hoff for manuscript preparation. This study was supported by the Human Herpesvirus (HHV-6) Foundation. We thank Ms Kristin Loomis and Dr Dharam Ablashi of the HHV-6 Foundation for their support of this project.",

year = "2011",

month = jul,

doi = "10.1093/ndt/gfr259",

language = "English (US)",

volume = "26",

pages = "2391--2393",

journal = "Proceedings of the European Dialysis and Transplant Association - European Renal Association. European Dialysis and Transplant Association - European Renal Association. Congress",

issn = "0931-0509",

publisher = "Oxford University Press",

number = "7",

}

TY - JOUR

T1 - Chromosomally integrated human herpesvirus-6 in kidney transplant recipients

AU - Lee, Sang Oh

AU - Brown, Robert A.

AU - Eid, Albert J.

AU - Razonable, Raymund R.

N1 - Funding Information: Acknowledgements. We thank Teresa Hoff for manuscript preparation. This study was supported by the Human Herpesvirus (HHV-6) Foundation. We thank Ms Kristin Loomis and Dr Dharam Ablashi of the HHV-6 Foundation for their support of this project.

PY - 2011/7

Y1 - 2011/7

N2 - Background. During primary infection, human herpesvirus-6 (HHV-6) may become integrated into the chromosome. This entity, termed chromosomally integrated HHV-6 (CIHHV-6), is often mistaken as active infection and treated unnecessarily. The prevalence of CIHHV-6 in kidney transplant recipients is not known.Methods. We performed quantitative HHV-6 polymerase chain reaction assay on whole blood samples collected from 47 kidney recipients. CIHHV-6 was defined as HHV-6 DNA levels >1 × 106 genomes/mL.Results. One of 47 kidney recipients was found to have CIHHV-6. The prevalence of CIHHV-6 was calculated at 2.1% (95% confidence interval, <0.01-12.1%). Despite an increase in HHV-6 DNA level after transplant, the patient did not develop clinical HHV-6 disease.Conclusions. CIHHV-6 may be observed in kidney transplant recipients. Clinicians should be aware of this entity so as not to provide unnecessary treatment to asymptomatic patients with CIHHV-6.

AB - Background. During primary infection, human herpesvirus-6 (HHV-6) may become integrated into the chromosome. This entity, termed chromosomally integrated HHV-6 (CIHHV-6), is often mistaken as active infection and treated unnecessarily. The prevalence of CIHHV-6 in kidney transplant recipients is not known.Methods. We performed quantitative HHV-6 polymerase chain reaction assay on whole blood samples collected from 47 kidney recipients. CIHHV-6 was defined as HHV-6 DNA levels >1 × 106 genomes/mL.Results. One of 47 kidney recipients was found to have CIHHV-6. The prevalence of CIHHV-6 was calculated at 2.1% (95% confidence interval, <0.01-12.1%). Despite an increase in HHV-6 DNA level after transplant, the patient did not develop clinical HHV-6 disease.Conclusions. CIHHV-6 may be observed in kidney transplant recipients. Clinicians should be aware of this entity so as not to provide unnecessary treatment to asymptomatic patients with CIHHV-6.

KW - chromosomal integration

KW - human herpesvirus-6

KW - infection

KW - kidney transplantation

KW - prevalence

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JO - Proceedings of the European Dialysis and Transplant Association - European Renal Association. European Dialysis and Transplant Association - European Renal Association. Congress

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SN - 0931-0509

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ER -

Chromosomally integrated human herpesvirus-6 in kidney transplant recipients

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