Chromosomally integrated human herpesvirus-6 in kidney transplant recipients

Sang Oh Lee, Robert A. Brown, Albert J. Eid, Raymund R Razonable

Research output: Contribution to journalArticle

17 Citations (Scopus)

Abstract

Background. During primary infection, human herpesvirus-6 (HHV-6) may become integrated into the chromosome. This entity, termed chromosomally integrated HHV-6 (CIHHV-6), is often mistaken as active infection and treated unnecessarily. The prevalence of CIHHV-6 in kidney transplant recipients is not known.Methods. We performed quantitative HHV-6 polymerase chain reaction assay on whole blood samples collected from 47 kidney recipients. CIHHV-6 was defined as HHV-6 DNA levels >1 × 106 genomes/mL.Results. One of 47 kidney recipients was found to have CIHHV-6. The prevalence of CIHHV-6 was calculated at 2.1% (95% confidence interval, <0.01-12.1%). Despite an increase in HHV-6 DNA level after transplant, the patient did not develop clinical HHV-6 disease.Conclusions. CIHHV-6 may be observed in kidney transplant recipients. Clinicians should be aware of this entity so as not to provide unnecessary treatment to asymptomatic patients with CIHHV-6.

Original languageEnglish (US)
Pages (from-to)2391-2393
Number of pages3
JournalNephrology Dialysis Transplantation
Volume26
Issue number7
DOIs
StatePublished - Jul 2011

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Human Herpesvirus 6
Kidney
Transplant Recipients
DNA
Infection

Keywords

  • chromosomal integration
  • human herpesvirus-6
  • infection
  • kidney transplantation
  • prevalence

ASJC Scopus subject areas

  • Nephrology
  • Transplantation

Cite this

Chromosomally integrated human herpesvirus-6 in kidney transplant recipients. / Lee, Sang Oh; Brown, Robert A.; Eid, Albert J.; Razonable, Raymund R.

In: Nephrology Dialysis Transplantation, Vol. 26, No. 7, 07.2011, p. 2391-2393.

Research output: Contribution to journalArticle

Lee, Sang Oh ; Brown, Robert A. ; Eid, Albert J. ; Razonable, Raymund R. / Chromosomally integrated human herpesvirus-6 in kidney transplant recipients. In: Nephrology Dialysis Transplantation. 2011 ; Vol. 26, No. 7. pp. 2391-2393.
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N2 - Background. During primary infection, human herpesvirus-6 (HHV-6) may become integrated into the chromosome. This entity, termed chromosomally integrated HHV-6 (CIHHV-6), is often mistaken as active infection and treated unnecessarily. The prevalence of CIHHV-6 in kidney transplant recipients is not known.Methods. We performed quantitative HHV-6 polymerase chain reaction assay on whole blood samples collected from 47 kidney recipients. CIHHV-6 was defined as HHV-6 DNA levels >1 × 106 genomes/mL.Results. One of 47 kidney recipients was found to have CIHHV-6. The prevalence of CIHHV-6 was calculated at 2.1% (95% confidence interval, <0.01-12.1%). Despite an increase in HHV-6 DNA level after transplant, the patient did not develop clinical HHV-6 disease.Conclusions. CIHHV-6 may be observed in kidney transplant recipients. Clinicians should be aware of this entity so as not to provide unnecessary treatment to asymptomatic patients with CIHHV-6.

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